Problem: to solve a disease, it's pathomechanism needs to be understood. Every researcher/individual is biased. Designing the wrong research strategy can delay solving a disease by decades. How to debias research proposals?

Finasteride surely isn't as harmless as many doctors, regulators & patients might think. This is worth reading carefully. https://t.co/psfIfqxWik

How it started (1992) How it’s going (2023)

"WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome" https://t.co/rxsorxSrI9 Induction of ER stress could play a role in several diseases that include fatigue. @MEcfsTogether @dg_mecfs #MECFS

Great and easy to understand post by @DrRuscioDC on gut dysbiosis and neuroinflammation. https://t.co/YwrIpta4OJ I would like to add that fasting and caloric restriction is also effective for dampening inflammation. https://t.co/PxykK4xg6z

@CosimoMelcangi

@JuhanaSakari @FinasterideInfo @Max94Cold

5.) Note that some PFS patients report to have a window of improvement after use of antibiotics or inuspheresis before usually relapsing. The bacteria could theoretically also cause autoimmune antibodies when getting in contact with the immune cells in the blood.

4.) I find it likely that brain fog in PFS is a sign of neuroinflammation. Gut inflammation and leaky gut after finasteride withdrawal might cause bacteria and LPS to enter the blood stream and cause neuroinflammation, depression & fatigue...

3.) Interstingly, a recent study by @CosimoMelcangi found inflammation in the gut of rats after 1 month after withdrawal of finasteride (increase of IL-1β and TNF-α). Leaky gut has not been confirmed in these animals - although I personally find it likely happens in PFS.

2.) The article states that in ME/CFS - inflammatory markers like (hs-) CRP increase - IL-10 is increased - glucose and citrate don't respond with elevation to exercise - bacteria enter the blood stream after exercise which probably causes brain fog, fatigue and malaise etc ...

1.) Interesting article on the possible cause of post-exercises malaise in ME/CFS https://t.co/ECNYyqBXyk @dg_mecfs @MECFS_Freiburg @MECFS_Bayern Interstingly, many Post-Finasteride Syndrome patients also report Post-exercises malaise...

Although little known, there is an Italian PFS Association. They are supporting Prof. Roberto Melcangi's next project. This is their fundraiser. FYI. https://t.co/ozpq9Cz68n

What research tool is the best for getting the best understanding of a the pathomechanism of a disease?

CW: male sexual dysfunction Corpora cavernosa (erectile tissue) showed ‘fragmented collagen and elastic fibers, degenerated muscle fibers and areas of fibrosis’ https://t.co/Mb5mLfoWAU

"I had no reference point for how bad this could be." Miles discusses how the persistent side effects of finasteride have upended his life. #postfinasteridesyndrome #pfs #metoopropecia h/t @BitcoinOasis86 https://t.co/ecCgQnG8Mv

@SimonBreidert 100% agreed. This is why an extensive literature review is the heart of every good thesis that gets published.

@CensoredMen Depression is overdiagnosed in the US, but for some people it really is a brain chemistry issue. But zombifying people with SSRIs for sure happens way too much. From what I’ve seen with friends, ketamine taken occasionally is a better option.

A research committee could reduce the bias of doing the wrong research.

Why I think that an inclusive research approach might work best for solving diseases like PFS or PSSD

2/2 ... Now I think research is more like building a highway: you don't want to build a highway 20 years into the wrong direction. It might be better to take all the time to think things through & make sure that the highway points in the right direction.