Does the gut #microbiome predispose patients to immunotherapy-related colitis? Our study in @JExpMed explores the #microbiota before, during, and after #colitis induced by #cancer #immunotherapy in a prospective cohort. Read here: #MedTwitter #GITwitter.

Still waiting on my Hogwarts acceptance letter, but excited to bring a dash of magic to the pathology lab.

RT @drdoubleb: I realized I needed to do something a little more creative with this #PathArt

RT @RockUPress: In @JExpMed, @Shang_Joa, @DavidFaleckMD, @jeremiahfaith1 et al. report that pretreatment gut #microbiomes of #immunotherapy….

I am immensely grateful for my mentor @jeremiahfaith1 and collaborators @DavidFaleckMD @JeanFredericCo1 and Dr Sacha Gnjatic. Thank you to @grahambiota @achenliaw @tsonipeled @ArielleElkrief and many others at @IcahnMountSinai @MSKCancerCenter for their help on this project✨.

4. We show how longitudinal microbiome profiling can help us better understand disease, which could pave the way to inform disease prevention and treatment strategies.

3. These changes normalized as colitis resolved, highlighting a transient, reversible shift. We also show parallels between inflammatory bowel disease and immunotherapy-related colitis.

2. During the first ten days of colitiis onset in patients, the microbiota showed reduced diversity, expanded Proteobacteria, and depleted beneficial species like Faecalibacterium prausnitzii.

1. Transplanting the pre-colitis microbiotas of patients to mice suggests a causal role of baseline microbiome composition in colitis development.

RT @JExpMed: .@Shang_Joa, @DavidFaleckMD, @jeremiahfaith1 et al. @IcahnMountSinai report that pretreatment gut #microbiomes of #immunothera….

During the first ten days of colitiis onset in patients, microbiota showed reduced diversity, expanded Proteobacteria, and depleted beneficial species like Faecalibacterium prausnitzii. These changes normalized as colitis resolved, highlighting a transient, reversible shift.

Transplanting the pre-colitis microbiotas of patients to mice suggests a causal role of baseline microbiome composition in colitis development.

It was great to be back at the #JointMeeting2024 in Chicago! It's a privilege to be part of the #PhysicianScientist community. Stellar presentations, events, and conversations this past weekend. #doubledoc #phd @A_P_S_A

Enjoyed presenting some of my dissertation work @JointMeeting today. Thanks to everyone who stopped by my poster to learn about the #gut #microbiome and immune-related colitis! . #doubledoc #phd

Successfully defended my thesis today! There are so many people to thank. I'm deeply grateful for my amazing thesis advisor @jeremiahfaith1's support all these years!. #phd #cancer #microbiome

RT @jeremiahfaith1: 1. Highlights from our recent preprint: Quantification of discrete gut bacterial strains following fecal transplantatio….

An inspirational seminar by Dr. Özlem Türeci from @BioNTech_Group today on mRNA vaccines against COVID, pancreatic cancer, melanoma, autoimmune diseases, and more @SinaiImmunol

Grateful to my mentor @jeremiahfaith1 for all his support and mentorship and for our wonderful collaborators @DavidFaleckMD @JeanFredericCo1, Dr. Sacha Gnjatic, and other teammates who make this multi-center study possible!.

It was a pleasure presenting our work on the #gut #microbiome and #immunotherapy related #colitis! Amazing posters + presentations by all the attendees including our own collaborators, @EdgarEGK and Dr. Cabel. Thank you @IOTNmoonshot for the early career speaker award and event!

RT @IOTNmoonshot: The 2nd day of the IOTN semi annual SC meeting is underway. Lots of exciting cutting edge research presented so far. Loo….