What are the structural features driving #HLA restriction of T cell receptors? This comprehensive analysis of interactions by @SagarGupta047 provides a classification system of polymorphic HLAs from different patients to inform the expansion of T cell-based therapies. Supported

Just out in @PNASNews ! Using the @UWproteindesign's SMART #MHCI concept we can now rapidly map interactions with #Tcell receptors by #NMR. This could accelerate immunotherapy development for #CancerGrandChallenges Teams MATCHMAKERS, NexTGen. Congratulations to @chw1228 and all

🎓Celebrating a major milestone: Two outstanding new PhDs, Drs. Yi Sun and Claire Woodward graduated in the 2025 @pennbgs ceremony-our lab's very first graduates from @BMBGGUPENN. We are all incredibly proud of their dedication and accomplishments. The future of science is bright

Spy-ing on nucleic acids: Atomic resolution of the S. pyogenes CRISPR-Cas9 surveillance state

Thrilled to congratulate Dr. Claire Woodward on her successful thesis defense! Her pioneering use of #NMR spectroscopy to investigate Interleukin-2 and other #Tcell signaling molecules has opened new windows into therapeutics design for immune regulation! Brilliant work that

What is the Role of MHC-I Proteins in Immune Surveillance?

💡 Members of @SgourakisLab in team NexTGen uncover novel mechanism of antigen selection, resolving long-standing questions in adaptive immunity. These findings could pave the way for advancements in cancer #Immunotherapy & #VaccineDevelopment. More 👉 https://t.co/wUGmRiH1dZ

Tired of running separate experiments using ELIspots and tetramers? Then use VLP-Open HLA - a versatile nanoparticle platform that can screen for #Tcell responses in vitro. Using SpyTag/SpyCatcher chemistry to conjugate our loadable, open #MHC-I molecules on engineered

@StanfordUChem @CHOP_Research @PennMedicine @scrippsresearch @bioe_stanford @StanfordCancer @czbiohub @PossuHuangLab @HaotianDu4 @SgourakisLab .@ChildrensPhila, @Stanford researchers reveal and refine new immunotherapy platform with increased potential to target cancer cells #NBTintheNews

...by targeting conserved #MHC-I residues, our TRACER-I platform is compatible with diverse #HLA allomorphs in patients – a game-changer for developing broadly accessible #CAR-T cells and #BiTEs for #immunotherapy. @NatureBiotech https://t.co/VwYB7VZl4m

...a key feature of our platform is its unique #antigen recognition mode: three helices that dock precisely onto the #MHC-I groove. Our X-ray structure reveals how this binding enables highly specific recognition of diverse antigens through a remarkably simple 8-residue peptide

Proud to unveil TRACER-I, a de novo protein platform developed through 5 years of collaboration with @PossuHuangLab. By recognizing diverse #MHC-I antigens (cancer, autoimmune & pathogenic), we're paving the way for more accessible immunotherapies. Congratulations to

"A structure is worth a thousand words!" Thank you David for instilling your passion for proteins, and making the most difficult problems in science look easy. It was an honor to join colleagues and friends for your proudest moment, looking forward to exciting times ahead!

🧬 Excited to share our new collaborative study with @drGregBowman and @SpanglerLab uncovering how protein dynamics regulate IL-2 cytokine immune signaling. Our #NMR data can help design new IL-2 variants. Congratulations to @chw1228 and coauthors!

🎉 Congratulations to DR! @YiSun1212 who successfully defended her PhD Thesis on molecular mechanisms of MHC-I antigen proofreading!

🧪 #NMR, why bother? Because it provides unprecedented insights into molecular mechanisms! Case in point: A dynamic switch within #Cas9's REC3 domain enables DNA proofreading function. Congratulations to Viviane De Paula and team for a beautiful paper :

Excited to share a new preprint! Using solution #NMR spectroscopy, we explored the #dynamics of the #cytokine interleukin-2 and ‘superkine’ variants, identifying a core allosteric network that enables enhanced receptor binding. @drGregBowman @SpanglerLab https://t.co/CAaUeZN8ff

Exciting news! @BB_UPenn has installed a new 800 MHz NMR instrument, supported by @HHMINEWS & @PennMedicine. Special thanks to @tolbertrnalab for making this possible. This cutting-edge resource will be invaluable for our @BMBGGUPENN grad students & the entire Penn community.

Incredible #ICMRBS in Seoul! 🇰🇷 Reunited with good friends and colleagues, explored cutting-edge #NMR research in talks & poster sessions, and shared our work on #MHC-I antigen proofreading by molecular #chaperones. Kudos to the organizers for a stellar meeting! 👏 #SciComm

New preprint alert! Our lab has captured the first glimpse of how #TAPBPR selects #antigens for #MHCI presentation. Focusing on a high-fidelity #immune checkpoint, our structural insights guide new approaches to #vaccine design and #cancer #immunotherapy. https://t.co/1zpK0XZBFz