Scacheri Lab
@ScacheriLab
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Epigenetics and human disease research lab at Case Western Reserve University School of Medicine -- Department of Genetics & Genome Sciences
Joined May 2014
Genome wide association studies have been used to identify genes that may be linked to opioid use disorder, but need hundreds of thousands of samples. @MeWantData & collaborators have developed a way to identify these genes, using a small # of samples: https://t.co/EpidCNdIAV
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Epigenetic convergence in opioid overdose. Great to see this multi-team collaboration in print! Such a great group of people on this project. S. Akbarian, D. Mash, E. Johnson, D. Hancock, @ScacheriLab @Bun_Without_B
https://t.co/1Esq61ykeR
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TWEETORIAL on our new #radonc paper in @TheLancetOncol -- joint work from @CCLRI @MoffittNews @CWRUSOM 1/n Pan-cancer prediction of radiotherapy benefit using genomic-adjusted radiation dose (GARD): a cohort-based pooled analysis https://t.co/3crLxn8VEP
@OncoAlert
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Also, big thanks to Richard Sallari and the @axiotlinc team.
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Our studies are expanding from cancer into other major public health crises. Check out our latest on opioid use disorder. Team effort with Akbarian, Johnson, Mash, and @CorradinLab.
biorxiv.org
Opioid dependence is a highly heterogeneous disease driven by a variety of genetic and environmental risk factors which have yet to be fully elucidated. We interrogated the effects of opioid depend...
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Recruiting talented data scientists and molecular biologists to work on our newly funded project 👇🏼! This is our collective brainchild with @BullmanLab & @CJohnstonLab1. Please retweet! Interested applicant please email tinga@ccf.org
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Fabulous ecDNA study by Henssen and Koche! Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma | Nature Communications
nature.com
Nature Communications - MYCN amplification is common in neuroblastomas. Here the authors analyse the MYCN amplicon structure and its epigenetic regulation by integrating short- and longread genomic...
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Evolutionary therapy is a new subfield in medicine (distinct from #evomed) that seeks to use our understanding of evolution to enable novel #cancer (& pathogen) therapy. Here we present the first link between #evotherapy and quantum physics. A #thread
https://t.co/8w3h3AliNh
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How does resistance to targeted therapy develop in #lungcancer? Is it pre-existence or a de novo mechanism? @AndriyMarusyk lab @MoffittResearch adds evidence for a truly Darwinian, gradual development from tolerant persisters to full resistance. A THREAD
nature.com
Nature Communications - Acquired resistance to cancer therapies reflects the ability of cancers to adapt to therapy-imposed selective pressures. Here, the authors elucidate the dynamics of...
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Congrats to @CorradinLab!
Multiple sclerosis (MS) is considered an autoimmune disease. Researchers in the @CorradinLab led by @annAmbarbeau & the @TesarLab led by Daniel Factor found a role in MS for cells in the central nervous system—a potential new avenue for MS therapies: https://t.co/qVxzuT7jDD
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Big congrats to freshly minted PhD, Andrew Morton. He just successfully defended his thesis online! @morton_andrew #DamnProud
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To stop COVID-19, test everyone, repeatedly - Sten Linnarsson - Medium
medium.com
This is a preprint, and has not been peer-reviewed.
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Finished off with some historical sites in Jerusalem, including the western wall. Great tour with @caseccc colleagues including @ScacheriLab
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Excellent preview in @Cancer_Cell covering recent work on the role of extrachromosomal circular DNA in cancer, including our study in @NatureGenet with @anton_gh et al. Thank you for the highlight, Chris Ott.
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A must read. Great work from Lupien Lab.
My team's latest publication deepening our understanding of the noncoding cancer genome: Noncoding mutations target cis -regulatory elements of the FOXA1 plexus in prostate cancer
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Check out our first preprint! Together with @RichardKoche @CMskcc we show that MYCN amplicon structure is not only determined by local enhancers , as shown by @ScacheriLab @CellCellPress but that chimeric amplicons can recruit distal enhancers leading to enhancer hijacking.
Enhancer hijacking determines intra- and extrachromosomal circular MYCN amplicon architecture in neuroblastoma https://t.co/YFvhzSZBIF
#biorxiv_cancer
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Here’s a link to read and download for those without a subscription. Check it out!
1/ So excited to have our work joint with the Rich lab lead by @morton_andrew published in Cell @CellCellPress today: “Functional enhancers shape extrachromosomal oncogene amplifications”. https://t.co/24hU8hvP3T
#tweetorial below
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ecDNA is hot! We encourage you to also read yesterday’s @nature paper lead by @mischellab @HowardYChang Bing Ren and Vineet Bafna. https://t.co/HK3lvORphG
nature.com
Nature - Imaging and sequencing approaches are combined to show that extrachromosomal DNA (ecDNA) in cancer is circular and has unique chromatin structure that amplifies oncogene output.
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