Satoru Yonekura, MD PhD
@Satoru_MD
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#Dermatology #Dermpath resident 🇯🇵 #AI #ImmunoOncology #microbiota BSc(@UTokyo_News_en), MD (@TMDUniversity), PhD(@UnivParisSaclay) | T/RT≠ medical advice |
Joined November 2020
New immune checkpoint affected by the gut #microbiome involved in lack of #immunotherapy responses in colon cancer. Read our double feature here: https://t.co/N18XGHnEJl
@FeliuVirginie @ChristelDevaud @TeamT2i @GustaveRoussy @CarolinaAlvesC5 @derosa__lisa #CRCSM
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@ScienceMagazine @CarolinaAlvesC5 @SciImmunology Finally, @Pratt__Brandon & @JJMilnerLab put these two exciting papers in context with an outstanding @ScienceMagazine Perspective! https://t.co/8JjAIFtP39
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@ScienceMagazine @CarolinaAlvesC5 See also Feliu & al. in @SciImmunology, which shows a positive role for gut-primed α4β7+ #CD8TCells against #ColonCancer #metastases in the mouse #liver! https://t.co/MTJPWr0c6E
science.org
α4β7+ CD8 T lymphocytes, specifically and locally primed by colon tumors, are key components of distant antimetastatic immune responses.
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Now in @ScienceMagazine , Fidelle, Rauber, @CarolinaAlvesC5, Zitvogel, & al. show after #ABX treatment in mice, #Enterocloster recolonize gut → ↘️ MAdCAM-1. α4β7+ #Tr17Cells can then traffic from gut to #tumors & compromise #checkpoint #immunotherapy! https://t.co/57VDCC1th8
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European, American and Asian researchers uniting over suchi and karaoke at #isid2023tokyo in beautiful #Japan. What a great conference!
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Brain metastases from #RCC treated with first-line therapies: results from the International Metastatic #RenalCellCarcinoma Database Consortium. @DrTakemura @UCalgary joins @PBarataMD @caseccc in this discussion on UroToday > https://t.co/nCj8HgupuB
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75 yo man with erythematous scaly plaque on dorsal hand. Your diagnosis? What are the pretty pink swirling structures? Answers (& more pics) here: https://t.co/UkIxvESCWi. Video: https://t.co/v8PwdH2bcM
#pathology #pathologists #pathTwitter #dermpath #dermatology #dermtwitter
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60 yo M. Multiple pruritic papules on trunk. Your diagnosis? Answer & video: https://t.co/sepxzzAt7T
#pathology #pathologists #pathTwitter #dermpath #dermatology #dermatologia #dermtwitter
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Patient who is a weight lifter and on an all protein diet. What has invaded the #brain on this #mri? #neurotwitter #meded #medtwitter #radtwitter
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What's your diagnosis? Hint: first image at https://t.co/gSSu0RI7WS
#dermatology #dermatologia #dermpath #dermtwitter
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What's your #dermatology #diagnosis? The patient responded to ustekinumab... https://t.co/tG0Wdsxmx3 via @JAMADerm part of @JAMANetwork #dermpath #dermtwitter #pathtwitter
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What a pleasure to finally meet @JenWargoMD , brilliant scientist and one of our greatest partners. Science is about sharing knowledge, effort and data. Let’s keep the pace, «the scoop is on the poop»!
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Current Issue: Impact of Body Mass Index on Survival Outcomes of Patients with Metastatic Renal Cell Carcinoma in the Immuno-oncology Era: A Systematic Review and Meta-analysis https://t.co/aShXGNNgXL
@Satoru_MD @DrDanielHeng
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From the April issue: Cancer-induced ileopathy and #dysbiosis by @Satoru_MD, @TerrisseSafae, @CarolinaAlvesC5, @derosa__lisa, #LaurenceZitvogel et al. https://t.co/qKJ1IOOgss
@GustaveRoussy @Inserm @UnivParisSaclay #ClinicObiome #Microbiome
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Will try to apply this pipeline in skin biopsy samples
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https://t.co/jDKgD5s9a2 This paper proposes a game-changing deep-learning strategy using only open-source softwares inclusing my favorite #QuPath ! Thanks to this, I would save much time and efforts!
arxiv.org
Application of deep learning on histopathological whole slide images (WSIs) holds promise of improving diagnostic efficiency and reproducibility but is largely dependent on the ability to write...
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#ICYMI: Cancer induces a stress ileopathy depending on B-adrenergic receptors and promoting #dysbiosis that contribute to carcinogenesis. @Satoru_MD @TerrisseSafae @CarolinaAlvesC5 @derosa__lisa @GustaveRoussy @Inserm @UnivParisSaclay
#LaurenceZitvogel #ClinicObiome #microbiome
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Now online in @CD_AACR: Cancer induces a stress ileopathy depending on B-adrenergic receptors and promoting #dysbiosis that contributes to carcinogenesis @Satoru_MD @TerrisseSafae @CarolinaAlvesC5 @derosa__lisa #LaurenceZitvogel @GustaveRoussy @inserm
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This study shows mono- and combined #ICB (CICB) shared gut #microbiome features in response. In addition, Bacteroides intestinalis up-regulated mucosal IL-1b and correlated with colitis. Targeting IL-1b might uncouple the response from #irAEs using CICB. https://t.co/vHs5Q40k1T
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