Sarah Perlee
@SarahPerlee
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Life Science Program Manager @PershingSqFdn | PhD @whitefishlab @MSKCancerCenter
NYC
Joined October 2012
š§¬ Augustās most-read #genetics paper shows how a new zebrafish tool (mitfa:Cas9) can reveal the genes driving melanocyte and melanoma development: https://t.co/xtMclwwaUf
#CRISPR Have a paper people should see? See what our Editors look for: https://t.co/ZJpcIXNkah
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How do genes that keep melanocytes alive affect #melanoma? Using a #zebrafish line with mitfa-driven Cas9, researchers show that knocking out survival genes can sometimes fuel more aggressive tumour traits. https://t.co/r84CzqrVL3
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Now out in @elife, @SarahPerleeās Ph.D. work developing a powerful way to knock genes out in #melanocytes and #melanoma cells. She created #zebrafish that allow for efficient CRISPR editing, and found unexpected things about genes required for these cells to thrive:
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Huge thank you to my mentor @whitefishlab and all of our wonderful collaborators!
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Excited to share my PhD work, now out in @eLife! š We developed a mitfa:Cas9 knock-in zebrafish line for lineage-specific genome editing, enabling in vivo screening for gene function in melanocytes and melanoma cells. Read more here:
elifesciences.org
A zebrafish Cas9 knock-in model enables lineage-specific gene disruption to uncover genetic dependencies in development and disease.
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Thanks to everyone who made this PhD possible! So grateful for my amazing mentor @whitefishlab, committee members, and the entire White lab for all their support these past 5 years! #PhDone
My last @GSKGradSchool student @SarahPerlee defending her Ph.D. with a tour de force of genetics and zebrafish. A perfect defense, joined by so many of her friends and family members!
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š£ 2024 ā¦@ZDMSocietyā© Cancer RIG meet up Webinars! Four ECR rising stars ā¦ā¦@SarahPerleeā© Tracy Jolly, ā¦@XiaodanQiā©, Clay Foster, four cutting edge Zebrafish cancer models. Free for members, $25 for RIG Webinars of all topics in 2024š
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Thrilled to have been able to share my work at #SMR23 this year. Truly an amazing experience engaging with such inspiring scientists. And huge thank you to @SocietyMelanoma for the travel award to attend this conference!
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Our new paper on electrical signalling between skin cells in #melanoma is out at @CD_AACR ā check it out! https://t.co/lywOwvMDHx. Before I get to the science, I want to highlight some really special things about @MohitaTagore, and how her innate curiosity made it happen.
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Phenomenal paper by an incredibly talented postdoc! I learned so much from working with @MohitaTagore on this project.
Delighted to share that my postdoctoral work is now online @CD_AACR Here we show a novel form of electrical activity based cell-cell communication in the melanoma microenvironment, and identify GABA as the mediator of this communication.
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So excited to share my first first-author paper!! Here we dive deeper into how SETD1A functions in leukemia cells and identify two novel binding partners, BuGZ and BUB3. @emboreports
https://t.co/WmeXYb7YL0
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Grateful beyond words for the incredible support and guidance I received from my PhD mentor @whitefishlab and previous mentors @Armstrong_dfci @thali_lab among many others in helping me secure the F31 award! So excited to continue my research journey with this funding.
It's always nice when someone smart, creative and kind gets good news - congrats to @SarahPerlee for her F31 award from the @theNCI! Despite a pandemic, a lab move and project evolution, she stuck with it all the way. She's an amazing geneticist who truly deserves this!
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Do you like development, regeneration, cancer? If so, come join us for a postdoc @Oxford. A love of #zebrafish helps, but we also like human #iPS cells. You can come and work on pretty much whatever you find interesting. Send me a message if interested.
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SETD1A regulates transcriptional pause release of heme biosynthesis genes in leukemia
cell.com
Hoshii etĀ al. report the role of histone-modifying enzyme SETD1A in the regulation of mitochondrial respiration in acute myeloid leukemia cells. They further show a non-enzymatic function of SETD1A...
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Great return to @SocietyMelanoma with many of my @MSKCancerCenter lab members. Check out posters from @mrndhntr @RichardHuang316 @SarahPerlee @shruthy_suresh @YilunMa_ @Eleanor_M_Johns @Joshua_M_Weiss. Spatial mechanics, anatomy, epigenetics, TME, lipids, metastasis in #zebrafish
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So happy to be presenting my work in Scotland at #SMR2022! Even better that I get to share this experience with so many @whitefishlab members and alumni.
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Very excited to see this work published! Congrats to @CutlerJevon, @BrandonJAubrey, and @Bourgeois_Wa for leading this phenomenal study. So glad to have been a part of this and I can't wait to see what's to come from @Armstrong_dfci.
š«ONLINE NOW @NatureCancer āIKAROS and MENIN coordinate therapeutically actionable leukemogenic gene expression in MLL-r acute myeloid leukemiaā @Armstrong_dfci by & Co. #Therapy Read it hereš https://t.co/pLUejMpu95
https://t.co/bAr9I9wvP2
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Zebrafish are commonly found in aquariums. But the researchers in @whitefishlab at the Sloan Kettering Institute study them to discover where cancer starts and how it spreads. Learn more about their latest research: https://t.co/LR1ONBTRp0
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Join us for āThe Roots of Changeā on 4/25 1pm EST to have critical discussion with remarkable women leaders Gloria Steinem, Elizabeth Blackburn, Ph.D., and Viviane Tabar, MD. An opportunity that canāt be missed!
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A longstanding question in cancer: why do tumors only form in certain locations in the body? In our new @nature paper ( https://t.co/tYb7lkOeYk), we define anatomic position of the cell as a mechanism for this.
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