@BWHNeuroICU @Brain_Circuits @_Anesthesiology.

The BIS monitor is used in ORs around the world. In patients comatose after cardiac arrest, we virtually-emulated BIS monitor output from clinical EEG. A neural network trained on this data out performed clinical gold-standard at predicting recovery.

RT @_Anesthesiology: In a new cover study, Snider et al. tested if internal EEG subparameters extracted by the BIS monitor—a device commonl….

RT @fredschaper_: Is generalized epilepsy a seizure of the whole brain or a specific brain network? . In our new paper out now in @NatureCo….

RT @ComaRecoveryLab: Visualizing Effective Connectivity in the Human Brain. Preprint: Code: .

RT @SpauldingRehab: Spaulding awarded two #TBI researchers $400K each in support of their new studies to understand mechanisms underlying d….

RT @wgibson: Happy to announce my next career step - I’ve launched my independent research lab at Dana Farber!. If you are a trainee intere….

RT @SamBSnider: "SQUEEZE MY HAND!" . Verbal commands like this are issued daily to traumatic brain injury patients in ICUs around the world….

RT @calvinwhow: Despite the urge to prognosticate in the early days after severe TBI, these results suggest we might take a little pause an….

RT @namorrismd: Very cool work/pragmatic work @SamBSnider. Would be fascinating to see a similar study in patients that are comatose after….

RT @stephanamayer: Now THIS good. ~10K severe TBI patients, excluding those who died in hospital. Every day from the point of impact, e….

We hope this data is a useful reference for clinicians who treat these patients (@namorrismd @caseyalbin @yasminaghajan @ComaRecoveryLab). Study led by @YelenaBodien. Collaboration: @BWHNeuroICU, @TBI_MS, and @PittNeurosurg. Contributions: @FloraHammondMD @rdz12135. 4/4.

Time to command-following is generally not a very good predictor, only weakly discriminating between 1-yr outcomes (AUC 0.6). A 90% likelihood of unfavorable outcome is reached only after MORE THAN 40 DAYS without command-following-- an extremely rare occurrence. 3/4

After a severe TBI, the risk of unfavorable 1-yr outcome increases by 1% with each additional day without command-following . This was observed in two independent studies, together including > 9,000 patients. We dub this the "1% rule". manuscript: 2/4

"SQUEEZE MY HAND!" . Verbal commands like this are issued daily to traumatic brain injury patients in ICUs around the world. Persistent absence of command following is felt to be a poor prognostic sign. Is it?. We share new results in @JAMANetworkOpen . 1/4

Early online version up now at: . Work led by @ComaRecoveryLab and @DamsOConnor in the LETBI dataset with funding from @NINDSfunding.

Online now in @braincomms: . We found that attentional impairment after traumatic brain injury (TBI) localizes to the sagittal stratum -- a widely connected white matter region. Implications for neuromodulation strategies in this population.

RT @shansiddiqi: Out @NatureNeuro: Network localization of brain stim targets for PTSD. TLDR: Lesions connected to this circuit REDUCE ris….

We used the BLAST-CT model- built by @mabmonteiro @GlockerBen. Thanks to @BWHNeurology @ComaRecoveryLab @foxmdphd for mentorship, @NIH_NINDS @AANmember for funding, and all participants and investigators from the TRACK-TBI study (@UCSFMedicine).

We found that location matters! . Temporal lobe hemorrhage volume improves the prognostic performance of the best currently-available prognostic model (IMPACT score). Now out in @JAMANetworkOpen .