Sagar Gupta
@SagarGupta047
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Building intuition | MD/PhD @PennMedicine
Joined August 2019
What are the structural features driving #HLA restriction of T cell receptors? This comprehensive analysis of interactions by @SagarGupta047 provides a classification system of polymorphic HLAs from different patients to inform the expansion of T cell-based therapies. Supported
Online now! A structure-guided approach to predict MHC-I restriction of T cell receptors for public antigens
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Proud to unveil TRACER-I, a de novo protein platform developed through 5 years of collaboration with @PossuHuangLab. By recognizing diverse #MHC-I antigens (cancer, autoimmune & pathogenic), we're paving the way for more accessible immunotherapies. Congratulations to
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In our new preprint, we leverage #structures of #TCR:pHLAs to classify #HLA molecular surfaces into T-cell cross-reactivity groups (T-CREGs). We apply our analysis to suggest #patient cohort expansion of existing TCR #immunotherapy treatments.
biorxiv.org
Peptides presented by class I major histocompatibility complex (MHC-I) proteins provide biomarkers for therapeutic targeting using T cell receptors (TCRs), TCR-mimicking antibodies (TMAs), or other...
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Grateful for the opportunity to work on this super cool project in the @SgourakisLab 🥳
Deciding which patients can receive #CAR T therapy is an important clinical question. By uncovering the structural basis of #MHC antigen recognition by a #neuroblastoma-targeting CAR we double the patient cohort and limit off-target toxicity @SciImmunology
https://t.co/e0ZHaBoRFM
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In a new @NatureComms paper, we present two new tools to aid the targeting of #cancer associated #antigens: 1) HLA3DB: a curated database of peptide/#HLA structures and 2) RepPred, a #pHLA structure prediction method that outperforms existing approaches
nature.com
Nature Communications - Structure prediction of peptide/HLA (pHLA) complexes has been mired by the inability to accurately model the middle of the peptide. Here, the authors present a curated...
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We’re so proud to see our @RosettaCommons summer intern present a poster at #RosettaCon! We enjoyed a lab reunion with @Santrupti62 and had a great time learning cool science from a wonderful community :)
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New paper that I'm proud to contribute to 🤗
In collab w/ the Maris lab @CHOP_Research, we solve the #structure of the peptide-centric #CAR bound to #PHOX2B/HLA-A*24! The PC-CAR can recognize #HLAs from the A9 CREG (25.2% USA pop freq) and a specific peptide backbone is req’d for optimal recognition https://t.co/MQx2hTU5nq
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Looking forward to presenting our posters today at 2:30 PM! #AAI2023 @ImmunologyAAI P444 - @YiSun1212 P443 - @SagarGupta047 P1026 - @papadakijo P1035 - @mikeyoungowlic
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Excited to be at #AAI2023! Check out our posters: P443 - @SagarGupta047 P444 - @YiSun1212 P1026 - @papadakijo P1035 - @MikeOwlicYoung
#immunology2023
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Really cool project that I had an opportunity to be a part of! Huge thank to Nik and Santrupti for their guidance and mentorship 😁🤩
#HLA3DB: fast & reliable structure prediction of #MHC-I complexes. @SagarGupta047 @SANTRUPTI62
https://t.co/yRyyTMyRTa
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Excited for my first paper to be published!!! Huge thanks to Dr. Francis at CSUB for this opportunity 😎😎
mdpi.com
Plant colonization by Streptomyces scabiei, the main cause of common scab disease on root and tuber crops, is triggered by cello-oligosaccharides, cellotriose being the most efficient elicitor. The...
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