Thomas Tan, Ph.D.
@SENGLAITAN
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Drug Hunter/Developer & Biotech Executive | Chief Scientific Officer at TFC (The First Cell) Therapeutics
New York, USA
Joined September 2010
Tissue-specific roles of regulatory T cells: mechanisms of suppression and beyond along with emerging therapeutic insights in autoimmune indications:
frontiersin.org
Regulatory T cells (Tregs) are central to immune homeostasis and controlling inflammation through multiple mechanisms, however, recent discoveries and advanc...
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Nice to see this paper, a long-time collaboration with Betsy Barnes' lab, is finally published "TLR-induced STK25 activation promotes IRF5-mediated inflammation" https://t.co/AEFV3nm0Nv
@LSAjournal #OpenAccess #lupus #SLE
life-science-alliance.org
The transcription factor interferon regulatory factor 5 (IRF5) functions as an important mediator of the inflammatory response downstream of MyD88-dependent TLRs. Whereas dysregulation of IRF5...
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🎉It's Scleroderma Awareness Month! Launching soon is an educational platform designed to support healthcare professionals in the management of scleroderma. 👉 Register now and stay informed all year round: https://t.co/qiHI3uud9t
#SclerodermaForum #SclerodermaAwarenessMonth
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An exciting moment for our team as we celebrated becoming a public company by ringing the #OpeningBell at @Nasdaq! This marks a new chapter in developing therapies for those living w/ #cancer. Thanks to our hard working & talented team who made this achievement possible. $BCAX
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Mechanism for how TGF-β and RAS work together to drive cancer metastasis: Cell
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A Compassionate, Patient-centric Approach to Cancer Prevention through Early Detection, by @Columbia @AzraRazaMD:
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Electrical Impulses Fire in Brain Cancer Tumors A new study has uncovered hybrid brain cells that are part neuron and part glia, capable of firing electric impulses. Previously, only neurons were believed to have this ability, but researchers found these hybrid cells in both
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I see hybrid cells. They're everywhere.
Glioblastoma induces the recruitment and differentiation of dendritic-like “hybrid” neutrophils from skull bone marrow https://t.co/5Y0EQnVjnt
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We're excited to share that we've closed our IPO & are listed on Nasdaq as $BCAX! This marks an important new chapter for our company as we aim to deliver transformative bifunctional therapies to patients with solid tumors. Thanks to all of our dedicated team members & partners.
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Human brain cancers fire electrical impulses -- researchers reveal unexpected hybrid cell spiking the signals
sciencedaily.com
Researcher have uncovered a new cell type in the human brain that fires electrical impulses. The cells are hybrids, part neuron and part glia, and are present in both glioma, a type of brain tumor,...
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It was a pleasure hosting Melissa Wong today and collaborating over our combined effort to redefine and eliminate #cancer Melissa Wong is Vice Chair and Professor in the Department of Cell, Developmental, & Cancer Biology @OHSUKnight
@ColumbiaMed #thefirstcell #curecancer
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Allergic Asthma Abated Using CAR T Cell Therapy in Mice https://t.co/Pn0QmJ3yFa via @GENbio
genengnews.com
Min Peng and his team used the CAR T technology to successfully treat not cancer, but chronic asthma using a mouse model.
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Patient-Specific Vascularized Tumor Model: Blocking TAM Recruitment wi...
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World’s first CAR-T cell therapy for a child with lupus
fau.eu
“One year after the treatment, I feel as good as I did before my diagnosis, except for a few colds,” says Uresa A. today. In June 2023, Uresa (who was 15 years old at the time) received CAR-T cells...
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Trex accepted for publication! We used single-cell TCR embeddings + RNA to infer antigen specificity and confirmed 5 of 5 predictions!
New models up for the #singlecell #TCR autoencoder Trex including results of training and encoding architecture. All compatible with scRepertoire/Seurat/Bioconductor. https://t.co/H8RTSv9Wnv
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Check out our most recent article about environmental impacts leading to CNS entry of CXCR3 B cells in MS! Big thanks to everyone for making this possible. @BecherLab, @MS_TWIN_STUDY, @SarahMundt5, @UlutekinCan, @LukasRindlis
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Reunited with Dan Littman, who kindly provided his PKC-theta KO mice. 18 years later, I'm trying to convince him to start a company targeting PKC-theta 😄
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