GerdesLab
@MS_TWIN_STUDY
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PI of national MS TWIN STUDY, clinician scientist, consultant in neuroimmunology @INIM_Munich, Institute of Clinical Neuroimmunology LMU Klinikum Munich,Germany
Munich Germany
Joined November 2020
🦠Are gut bacteria the trigger of Multiple Sclerosis ? 🧠 ➡️ Check how @MS_TWIN_STUDY helps to chase the microbial offender and read our REVIEW (together with @LabPeters) to learn more: https://t.co/u5Tc4krQAY 😉 Just in time for #WorldMSDay
#multiplesclerosis
onlinelibrary.wiley.com
Multiple sclerosis (MS) affects more than 2.8 million people worldwide but the distribution is not even. Although over 200 gene variants have been associated with susceptibility, studies of genetic...
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A really groundbreaking study that has the potential to identify patients at risk for developing MS years in advance. Congrats to @ColinZamecnik @gavin_sowa, Michael Wilson and team! https://t.co/OOagBygj1P
nature.com
Nature Medicine - An antibody screen of two distinct multiple sclerosis cohorts reveals an autoantibody signature that is detectable years before symptom onset and linked to a common microbial motif.
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Results of the TREAT-SVDs trial are now available online in @TheLancetNeuro! See our findings on #antihypertensive drugs in people with small vessel disease. Thanks to the teams in Edinburgh, Oxford, Utrecht, Maastricht, and Munich for this wonderful collaboration.
In a multicentre, open-label, randomised crossover trial, Anna Kopczak and colleagues explore whether antihypertensive drug classes differentially affect microvascular function in people with small vessel disease. https://t.co/UO3eU8CZLm
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Herzlichen Glückwunsch! Der LMU-Physiker Ferenc Krausz wird für seine Arbeiten zur Attosekundenphysik mit dem #Nobelpreis für #Physik ausgezeichnet! @MPI_Quantum @nobelprize
https://t.co/hpLKELkOdZ
lmu.de
Der Inhaber des Lehrstuhls für Experimentalphysik / Laserphysik an der LMU wird zusammen mit zwei anderen Forschenden für seine Arbeiten zur Attosekundenphysik mit dem diesjährigen Nobelpreis für...
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Conducting a genome-wide CRISPR screen, a team led by Martin Kerschensteiner @Ker_Lab and Naoto Kawakami @KawakamiLab was able to provide a definite molecular characterization of the central step in MS pathogenesis https://t.co/5EZi68QCt9
lmu.de
By means of CRISPR screening, LMU researchers have provided the first ever comprehensive molecular characterization of T cell infiltration into the central nervous system of people with MS.
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🔬 Exciting news! Our latest paper, together with @Ker_Lab, is out now in @NatureNeuro ! 📚 We conducted a genome-wide in vivo #CRISPR screen to uncover regulators of T cell migration into the CNS in a multiple sclerosis model. Check out the details! 🐀🧬 https://t.co/S2ETLyVVN4
nature.com
Nature Neuroscience - Multiple sclerosis (MS) lesions are initiated by the infiltration of T cells to the CNS. Here, Kendirli et al. use a genome-wide CRISPR screen in an MS model to define the...
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Very happy to share this preprint from my lab and so proud of my team and collaborators! Want to see (live!) what T and B cells are doing in meningeal follicles? Check it out: T:B cell cooperation in ectopic lymphoid follicles propagates CNS autoimmunity
biorxiv.org
Meningeal ectopic lymphoid follicle-like structures (eLFs) have been described in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE), but their role in CNS...
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Check out our latest research published in @PNAS 🎉🔬Using our intravital imaging approach, we provide direct footage of microbiota-mediated T cell activation in the ileal lamina propria resulting in phenotypical changes of the encephalitogenic T cells.
pnas.org
Autoreactive encephalitogenic T cells exist in the healthy immune repertoire but need a trigger to induce CNS inflammation. The underlying mechanis...
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Interesting single case from @INIM_Munich @MS_TWIN_STUDY, we published this in response to https://t.co/ylSm1zPY1h Induction of MOG-IgG could be triggered by molecular mimicry or bystander activation of pre-existing MOG-specific memory B cells #MOGAD
onlinelibrary.wiley.com
Click on the article title to read more.
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Very excited to share our recent publication investigating the effector functions of MOG-antibodies! It was a truly collaborative work! @LabMader @LabMeinl @KawakamiLab
pnas.org
Autoantibodies against myelin oligodendrocyte glycoprotein (MOG) have recently been established to define a new disease entity, MOG-antibody-associ...
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Thank you for an excellent and inspiring talk! Looking forward to future collaboration with @proebstellab, @LabPeters on #neuroinflammation and the link to the gut microbiome in the @MS_TWIN_STUDY ! Save trip home and see you soon!
Ending a fantastic day at my alma mater @LMU_Muenchen discussing @proebstellab most recent findings on B cell-microbiota interactions in #neuroinflammation and kicking-off new collaborations with @ThalerLab @LabMader @LabMeinl @Ker_Lab @MS_TWIN_STUDY. Thanks a lot for the invite!
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Today is International Women Day #IWD2023 and #iWiMS would like to recognise all the fantastic women researching #MultipleSclerosis and caring for #pwMS. Thank you!
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@OvercomingMS The 6 studies used on the @OvercomingMS site to back the claim of a link between dairy & MS are old (from 1992-2006); none are conclusive. Plus 1 shows a possible link between mice & MS. We are not mice. Wld love to see stronger evidence. https://t.co/WvrwpXUHDa
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radiologically isolated syndrome: revised diagnostic criteria https://t.co/WhSF9jXDkn
@CRCSEPNice #RISC#SFSEP#OFSEP. So proud of the RIS Family. What a journey!
academic.oup.com
Lebrun-Frénay et al. show that individuals who do not meet the diagnostic criteria for radiologically isolated syndrome based on their number of white matt
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Take a look inside the brain with optical coherence tomography (#OCT)! Why is this possible? How does it work? And does it hurt? 😏 I discuss these and other questions wth Minh Schumacher in his #podcast (in German)! #NMOSD #MOGAD #MS @INIM_Munich
ms-im-fokus.podigee.io
Warum in aller Welt sollte man MS PatientInnen ins Auge schauen? Was kann man dort sehen? Das und vieles mehr behandeln wir in unserer Folge zum OCT, der optischen Kohärenztomographie. Mein heutiger...
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Check out our new manuscript. Many thanks for this great collaboration: @Samanth68485267, Eva Oswald, Hoi Kiu Wong, @AtayVural, Vuslat Yilmaz, Erdem Tüzün, Recai Türkoğlu, Tobias Straub, Ingrid Meinl, @ThalerLab, Tania Kümpfel @LabMeinl,@LabMader
Happy to contribute to this exciting study that uncovers a novel mechanism of effect for ocrelizumab on the BAFF-APRIL system. Cheers to my colleagues Simone Mader and Edgar Meinl and other collaborators 🥂 https://t.co/3GdqQrOMuW
@LabMeinl @LabMader
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Multiple Sklerose: Epstein-Barr-Virus möglicherweise ursächlich: Münster – Die zelluläre Immunantwort gegen das Epstein-Barr-Virus (EBV) ist bei Patienten mit Multiple Sklerose (MS) vielfältiger. Eine EBV-Infektion in Kombination mit veränderten… https://t.co/KTiTv8Mn5o
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Happy to share this great coverage (for all audiences) of our work by Marcus Neitzert at @DZNE_en
#TREM2 #DIAN #AlzheimersDisease @Haass_Lab
https://t.co/Wo3AaAUN8R
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