Thomas Perlmann
@perlmannlab
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Members of Thomas Perlmann's group at Karolinska Institutet mostly tweet about exciting science and the Nobel Prize in Physiology or Medicine.
Stockholm, Sweden
Joined September 2019
RT @Dev_journal: New insights into what makes midbrain progenitors tick. Read this Research Highlight showcasing work from Laura Lahti, Tho….
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Incredible research lecture by the brilliant @michelle_monje today at Nobel Forum! A true treat for a packed auditorium!
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RT @ScienceAcad_swe: 🌟Sjöberg Laureate discovered new targets for cancer therapies in the immune system!🌟.@MiriamMerad, Mount Sinai Health….
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Exciting new study from Mantas, Meletis and colleagues, demonstrating function of vulnerable DA neurons in procedural motor learning. Great work!.
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Excellent presentations yesterday @NobelWeek in Nobel Forum @karolinskainst. Thanks to Jim Allison, Padmanee Sharma, Laurence Zitvogel, Mikael Karlsson, and Camilla Engblom!
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This year's Nobel Laureate harvest is now secured at Arlanda airport. Yesterday: Gary Ruvkun, Natasha Staller, and Victoria Ruvkun. Today: Victor Ambros and Rosalind Lee. With Nobel Attachés August Borg, Anna Wikner, and drivers.
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Thanks to Michael Piper, Richard Gronostajski, and all other authors for their contributions! 5/5.
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The ependymal derivatives of mDA progenitors in the adult retained several mDA progenitor characteristics but also expressed, e.g., Pdyn, the precursor of opioid peptides. These specific ependymal cells might form a novel type of circumventricular organ. 4/5.
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In embryos lacking Nfib, Nfix and Sox9, we could see, on average, +60% mDA neurons by E18. However, their inactivation after completing mDA neurogenesis had very little impact. 3/5.
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We identified transcription factors Nfib, Nfix, and Sox9 as regulators of cell cycle exit in mouse mDA progenitors. Their early inactivation in the midbrain leads to delayed mitotic exit and ependymal maturation, impaired gliogenesis, and increased neurogenesis. 2/5.
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A new preprint from our lab is now online in Biorxiv. Thread 1/5.
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Great meeting in Utrecht today! Many thanks for the opportunity to participate!.
Here today at @DPSConference24 , fascinating keynote from @perlmannlab all about dopamine neurons and their origins #parkinsonsdisease
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…. and only around 14 hours until the famous call from Stockholm. Here’s the phone I’ll use. If you expect the call, please stay alert @ around 9.30-10 CEST tomorrow!
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In about 24 hours, the votes from Nobel Assembly members will be collected in this brass bucket. Welcome to watch the announcement of the 2024 Nobel Prize in Physiology or Medicine @NobelPrize CEST 11:30 am!
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. followed by dinner with science legend, Joe Goldstein.
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It was great participating in this year's @LaskerFDN award ceremony! Mike Brown introduced James Chen to the basic award for the discovery of cGAMP/cGAS.
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Such a pleasure being your collaborator, Ioannis! Great work!.
I am pleased to share our publication on the crucial role of Nurr1 in modulating the response to hallucinogens in the claustrum. A huge thank you to @perlmannlab, @giacomello_lab, @CarlenLab and @Boehringer.#Claustrum #Nurr1 #Hallucinations.
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Nobel Assembly in session today, closing in on decision day in less than 4 weeks! Watch out for the Nobel Prize announcement on Monday, October 7 at 11.30 am (CET).
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An interesting and, for the most part, positive experience with the new eLife publishing model.
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Finally, our dopamine neuron atlas is out, uncovering unexpected diversity and differential vulnerability of different groups of DA neurons. Great job by @b_yaghmaeian, @DrGloom, Linda, Jesper, and Ioannis. Thanks to @PerSvenningsson for a great collaboration.
In @eLife: Transcriptomic atlas of midbrain dopamine neurons uncovers differential vulnerability in a Parkinsonism lesion model
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