RehlingLab
@RehlingLab
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Department of Cellular Biochemistry University Medical Center Goettingen and @mpi_nat. We study mitochondrial biogenesis in health and disease
Goettingen, Germany
Joined May 2021
My paper is out in @ScienceMagazine! We found a novel host defense strategy where #mitochondria, our domesticated microbes, compete with the intracellular pathogen #Toxoplasma for #folate. https://t.co/cDwlHtS4kB
science.org
As major consumers of cellular metabolites, mitochondria are poised to compete with invading microbes for the nutrients that they need to grow. Whether cells exploit mitochondrial metabolism to...
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New in @ScienceMagazine with a related Perspective Mitochondria protect against an intracellular pathogen by restricting access to folate | Science
science.org
As major consumers of cellular metabolites, mitochondria are poised to compete with invading microbes for the nutrients that they need to grow. Whether cells exploit mitochondrial metabolism to...
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Silencing mitochondrial gene expression in living cells | Science
science.org
Mitochondria fulfill central functions in metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, the central...
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Silencing mitochondrial gene expression in living cells | Science https://t.co/wRDoCKbFzT - Now available in new Science issue. Thanks again to all colleagues for a wonderful collaboration. Awesome work of LD Cruz-Zaragoza!
science.org
Mitochondria fulfill central functions in metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, the central...
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Online Now: Structural basis for promoter recognition and transcription factor binding and release in human mitochondria https://t.co/1lrVvttR8Q
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Ein starkes Signal für Wissenschaft und Innovation! Vielen Dank an den Freistaat Bayern, @Markus_Soeder und @MarkusBlume für die Unterstützung beim Ausbau der #Spitzenforschung und der Life-Sciences in Bayern.
Bayern ist eine führende Hightech-Region in Europa. Heute war dazu ein weiterer Meilenstein im Kabinett: Wir starten Europas stärksten Life-Science-Campus in Martinsried bei München gemeinsam mit der Max-Planck-Gesellschaft. Das ist zentral für den Pharma- und Medizinstandort
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Our story about FASTKD5 is now published at @NAR_Open. It was an amazing collaboration with @hauke_hillen and @Antonio41949078 labs. https://t.co/Ixj5LzMWwX FASTKD5 processes mitochondrial pre-mRNAs at non-canonical cleavage sites
academic.oup.com
Abstract. The first post-transcriptional step in mammalian mitochondrial gene expression, required for the synthesis of the 13 polypeptides encoded in mito
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Our study on how mitochondrial methylation shapes gene expression is now out. Using long-read RNAseq and cryo-EM, we uncover two methylation-dependent checkpoints in ribosome biogenesis. Read all about it at:
Our study on methylation during mitochondrial gene expression is now online. Great effort by @ruth_icg, Vivek Singh, @A_Amunts, and @MolMet_KI. https://t.co/JWQpbvLDX4
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Online now - Discussing the future of mitochondrial biochemistry
cell.com
Mitochondrial biochemistry is rapidly advancing, revealing these organelles as dynamic integrators of cellular physiology beyond their classic role in energy production. In this TrendsTalk, leading...
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SMIM20 promotes complex IV biogenesis and Ca2+ signaling in mice heart: Cell Reports https://t.co/Xx6Tn8yxGm. Great collaboration with @niels_voigt, @CZphenogenomics, D. Katschinski, & H. Urlaub. Thanks to Angela Boshnakovska, Laura Kremer and our lab!
cell.com
Boshnakovska et al. show that loss of the complex IV assembly factor SMIM20 in mice impairs complex IV function and causes a cardiac phenotype. SMIM20−/− mice demonstrate increased complex I activity...
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Silencing mitochondrial gene expression in living cells | Science https://t.co/wRDoCKbFzT. Wonderful that our paper is out now in Science. A big thanks to LD Cruz-Zaragoza and the team, @warscheidlab & @JakobsLab .
science.org
Mitochondria fulfill central functions in metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, the central...
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Great collaboration with @hauke_hillen and @RehlingLab. Thank you very much to everyone involved.
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If you’re curious about the intricate control of human mitochondrial translation, take a look at our latest review - just out!
Online now - Emerging mechanisms of human mitochondrial translation regulation
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Understanding mitochondrial protein import: a revised model of the presequence translocase: Trends in Biochemical Sciences https://t.co/OJqShFHnXo. New review, describing current advances regarding the TIM23 complex. Great work by Naintara Jain together with Agnieszka Chacinska.
cell.com
Mitochondrial function relies on the precise targeting and import of cytosolic proteins into mitochondrial subcompartments. Most matrix-targeted proteins follow the presequence pathway, which directs...
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In situ architecture of the human prohibitin complex https://t.co/eCJrppZDGx
nature.com
Nature Cell Biology - Lange, Ratz, et al. investigate the number and distribution of human prohibitin complexes in the mitochondrial inner membrane, uncovering their bell-shaped structure and...
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We recruit leaders on different stages and offer unique atmosphere of a vibrant an open research community. Strenghtening interdyscyplinarity is well seen! Also for: - Scientists with commercialization interests and/or targeted projects !!! - US based scientists !!!
IMol opens call for new Group Leaders. Apply by 15.03.2025 More details: https://t.co/GBbrFfwpJS
https://t.co/CzO7cqVaC3
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A microscopy-based screen identifies cellular kinases modulating mitochondrial translation: Cell Reports https://t.co/HYNk6iYU9k. a great end of the year. Thanks to our collaborators @RDennerlein_Lab, @RizzoliSilvio @DavidPacheu and Henning Urlaub
cell.com
Mitochondrial DNA encodes 13 OXPHOS subunits, which are synthesized inside the organelle. To address how mitochondrial gene expression integrates into cellular physiology, Yousefi et al. established...
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Valenti, David, Schuldiner et al. @WeizmannScience created a proteome-wide yeast degron library for rapid in vivo protein depletion. This tool enables dynamic protein function studies with minimal cellular rewiring, advancing beyond prior collections. https://t.co/ew8sNr6NYo
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