Ricarda Richter-Dennerlein
@RDennerlein_Lab
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Professor at University Medical Center Göttingen; Interested in mitochondrial biology and gene expression
Joined May 2021
Join us for the 1st Symposium on Interconnections and Cross-Regulation of Gene Expression Processes this September in Göttingen! Great Lineup of speakers and plenty of opportunities for early career researchers to present & discuss their work! Link: https://t.co/XiaeMCjwZi
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Silencing mitochondrial gene expression in living cells | Science https://t.co/wRDoCKbFzT. Wonderful that our paper is out now in Science. A big thanks to LD Cruz-Zaragoza and the team, @warscheidlab & @JakobsLab .
science.org
Mitochondria fulfill central functions in metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, the central...
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Our data suggest that i) mtSSU biogenesis & formation of initiation complexes (IC) are not mutually exclusive processes but can occur simultaneously, and ii) MTG3 acts as a quality control factor coupling late mtSSU maturation with IC formation primed for translation initiation.
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Great collaboration with @hauke_hillen and @RehlingLab. Thank you very much to everyone involved.
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Happy to share our recent work on “Coupling of ribosome biogenesis and translation initiation in human mitochondria” published in @NatureComms. Fantastic team effort of two talented PhD students - Marleen Heinrichs and @franziska_f1nke. https://t.co/eI4Tz3YF8e
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We recruit leaders on different stages and offer unique atmosphere of a vibrant an open research community. Strenghtening interdyscyplinarity is well seen! Also for: - Scientists with commercialization interests and/or targeted projects !!! - US based scientists !!!
IMol opens call for new Group Leaders. Apply by 15.03.2025 More details: https://t.co/GBbrFfwpJS
https://t.co/CzO7cqVaC3
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A microscopy-based screen identifies cellular kinases modulating mitochondrial translation: Cell Reports https://t.co/HYNk6iYU9k. a great end of the year. Thanks to our collaborators @RDennerlein_Lab, @RizzoliSilvio @DavidPacheu and Henning Urlaub
cell.com
Mitochondrial DNA encodes 13 OXPHOS subunits, which are synthesized inside the organelle. To address how mitochondrial gene expression integrates into cellular physiology, Yousefi et al. established...
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The peer-reviewed version of our paper on human tRNA 3' processing is now published in @NatureSMB. Many thanks to the reviewers for their constructive comments! https://t.co/CckIvTOOxX See also the very nice related work by @BMartinHallberg @no1gv:
embopress.org
imageimageThe human mitochondrial RNase Z complex is essential for the production of mitochondrial tRNAs. This study reveals its complete structural framework, detailing its role in tRNA maturation...
Happy to share a new preprint, in which we describe the mechanism of human tRNA 3' processing. We show why the RNase Z ELAC2 acts as a monomer in the nucleus, but forms a multi-subunit complex in mitochondria. Plase see 🧵 by @BhattaArjun2p for details! https://t.co/cY5Dj66wkw
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📢 Only few more days left to submit an abstract for #INTERPHACE2025 at @TheCrick or get an early-bird ticket! - deadline 13th Dec Don't miss out on presenting your work in an interdisciplinary environment, network, or maybe even find new collaborators? https://t.co/XIyWhfhubq
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A biologist and a mathematician walk into @TheCrick - Curious what happens? Register now for #INTERPHACE2025! ✨Organised by ECRs for ECRs & everyone else ✨Early-bird & 2 for 1 deals! ✨Abstract submission deadline extended to 13/12 ✨Great line-up of confirmed speakers ⬇️
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We are recruiting! Interested in #mitochondria #ribosome and looking for a PhD position? We have two open positions @yourUMG integrated in the collaborative research centre 1565 funded by the German Research Foundation (DFG). 👇 https://t.co/03spEZKiZY
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📢 The first edition of the INTERPHACE symposium will take place on 24/02/2025 @TheCrick 📢 Experimental and computational collaboration = exciting science! 💥 Register now and submit an abstract: https://t.co/FDV7GD7ezv Please RT!
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Research teams led by @RDennerlein_Lab @yourUMG, @JLiepe & Henning Urlaub @mpi_nat have now provided a roadmap for how human #mitoribosomes – protein factories in #mitochondria – are assembled in a modular fashion. ⬇️ @NatureSMB #protein #RNA
https://t.co/CPsDnqIR23
mpinat.mpg.de
Göttingen researchers have discovered how the human cell assembles mitoribosomes in a modular fashion.
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The formation of these protein-only complexes is independent of the rRNA and our data indicate that rRNA synthesis is the rate-limiting step during ribosome assembly in human mitochondria.
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We show that mitochondrial ribosomes assemble via protein-only modules, which are formed in excess and which present primed building blocks for the progression of subunit assembly.
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@hanna_roetschke @yehorokhovskyi @MartinPasen @yourUMG @mpi_nat
#mitoribosome #ribosome #mitochondria We report the first comprehensive assembly map for the human mitochondrial ribosome – from very early to late assembly steps.
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Excited to share our recent work “A Roadmap for Ribosome Assembly in Human Mitochondria” @NatureSMB A great team effort together with the groups of Henning Urlaub and @JLiepe. Fantastic work by @lavdovskaia. Thanks to everyone involved. https://t.co/VDl5pzRrX8
nature.com
Nature Structural & Molecular Biology - Lavdovskaia, Hanitsch, Linden et al. provide a comprehensive roadmap of mitoribosome biogenesis and establish that mitochondria use a unique pathway for...
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Registration extended to June 10th!
Join us for the 8th EMBO/FEBS lecture course on “Mitochondria in life, death and disease” – 16-20 September 2024, Landshut (Munich, GERMANY). Registration is open until 31 May 2024. #EMBOmitochondria #mito
https://t.co/9kRkakPqJh
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Two weeks left to register for the 8th EMBO/FEBS lecture course on “Mitochondria in life, death and disease” (16-20 September). Amazing line-up of speakers and many possibilities for early career scientists to discuss science and career paths. #EMBOmitochondria #mito
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