
Powerhouse Biology
@Powerhouse_Bio
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On a mission to reboot the human powerplant
San Carlos, CA
Joined July 2024
First day on site! @arubikscube joined Powerhouse Biology as a Computational Scientist. He’s our trailblazer on multi-modal network models and ML analysis, and he’s set to grow and shape our computational team. We were instant fans: his creative spark and bold move (yep, he
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We can't wrap our head around how she does it all - our champion CSO @rachel8407 just published "The AI drug revolution needs a revolution" in npj Drug Discovery. Rachel co-founded Powerhouse Biology with a vision to implement AI-guided multi-modal analysis of mitochondrial.
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First data in!!. We've transferred into the brand-new office and laboratory space at MBC BioLabs in San Carlos! Huge thanks to the MBC team for moving mountains to get us (and many others) to work, and to @LeicaMicro for helping us hit the ground running with core equipment and
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RT @foresightinst: Thanks to everyone who joined our AI x Bio workshop this weekend! 180 scientists, entrepreneurs, engineers, and funders….
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RT @BiocomCA: Happy #NewMemberMonday!.👩🔬 @Powerhouse_Bio makes precision peptide therapeutics to combat mitochondrial dysfunction.💡 @serna….
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Technically challenging and historically siloed from broader genomics and therapeutic innovation, mitochondrial biology is now at the center of converging tools, data, and demand. We are incredibly excited to see @virushunter and @ARIA_research opening up an opportunity space in.
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RT @sethbannon: NIH grants frozen. Discoveries delayed. PhDs pushed out. Academia getting gutted. Innovation must continue. There’s never….
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RT @NatureBiotech: A human metabolic map of pharmacological perturbations reveals drug modes of action https://t.co….
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RT @NatMetabolism: Top altmetrics score 2024: #16🏆✨. @mitopinionated (@karolinskainst) and co-authors describe how inhibition of mitochondr….
nature.com
Nature Metabolism - Inhibitor of mitochondrial transcription treatment leads to reduced oxidative phosphorylation capacity but increases fatty acid oxidation in the liver, leading to protection...
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New in @Nature: Analysis of 56,434 human mitochondrial genomes through a constraint model for mtDNA. It reveals which positions are highly constrained - that's a huge advance in our understanding of pathogenic variants and mitochondrial disease. Importantly, though, it's also an.
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RT @AsimovBio: Over the years, people have asked: What does Asimov do? This is our brief response. At a high level, we think biology is an….
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RT @AsimovPress: Written by Liyam Chitayat. Read the essay and subscribe!
press.asimov.com
The physical world is an intricate dance between matter, information, and energy. Recognizing that mitochondria are alive will open new horizons into how we learn about, and build with, biology.
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RT @SagerGosai: I’m thrilled to share that our paper “Machine-guided design of cell-type-targeting cis-regulatory elements” was published o….
nature.com
Nature - A generalizable framework to prospectively engineer cis-regulatory elements from massively parallel reporter assay models can be used to write fit-for-purpose regulatory code.
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RT @CultivariumFRO: 🎉 Congratulations to all the #iGEM2024 Grand Jamboree finalists! Your hard work and innovation to push the boundaries o….
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1/2.Engineered human mitochondrial DNA (mtDNA): Yi Fu, Max Land et al. did it in and it's absolutely wild. For context, in contrast to the tech available to manipulate our nuclear genome, we've barely touched human mtDNA. Following recent advances in.
biorxiv.org
Recent breakthroughs in the genetic manipulation of mitochondrial DNA (mtDNA) have enabled the precise introduction of base substitutions and the effective removal of genomes carrying harmful...
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RT @faunabio: We’re humbled for our work to be featured in @NatureMedicine. Thanks for speaking with our CEO @ashleyz413 and we’re excited….
nature.com
Nature Medicine - By understanding the biology of hibernating animals, scientists are developing new treatments to trigger weight loss and alter metabolic pathways.
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