Alicia Pickrell
@PickrellLab
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Twin tots mommy. Mito PI. Wifey to neuroscientist PI.
Blacksburg, VA
Joined October 2017
RT @Emit38935125: Modelling POLG mutations in mice unravels a critical role of POLγΒ in regulating phenotypic severity. .
nature.com
Nature Communications - POLG mutations impair mitochondrial DNA replication and cause diverse mitochondrial diseases. Here, the authors show that structural differences in the POLγB subunit...
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RT @Hiraselab_KU: Specific targeting of brain endothelial cells using enhancer AAV vectors: Neuron . (pleased to kn….
cell.com
Velazquez-Rivera et al. have developed and validated a set of new BEC-enhancer AAV vectors that allow for selective genetic labeling of, and access to, brain endothelial cells (BECs). These useful...
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RT @LukensJohnR: STING deletion protects against amyloid β–induced Alzheimer's disease pathogenesis
alz-journals.onlinelibrary.wiley.com
INTRODUCTION While immune dysfunction has been increasingly linked to Alzheimer's disease (AD) progression, many major innate immune signaling molecules have yet to be explored in AD pathogenesis...
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RT @RehlingLab: Silencing mitochondrial gene expression in living cells | Science Wonderful that our paper is out….
science.org
Mitochondria fulfill central functions in metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, the central...
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RT @JCellBiol: The #mitophagy receptors BNIP3 and NIX mediate tight attachment and expansion of the isolation membrane to #mitochondria, sa….
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RT @deadoc80: Here comes our @NatImmunol N&V on a recent @Nature paper by the Chi lab @StJude on #mitochondria in the regulation of #IFN s….
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RT @MichaelOkun: BREAKING: Your brain’s connective tissue isn’t just glue: It’s a switchboard for neuromodulation. We used to think that as….
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RT @J_Cell_Sci: Metin Özdemir, Sven Dennerlein and colleagues define a TOM complex interactome, revealing diverse interaction partners that….
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RT @NatureNeuro: Neuronal activity influences the growth of #myelin sheaths along axons by signalling through metabotropic glutamate recept….
nature.com
Nature Neuroscience - Employing pharmacology, genetics and all-optical approaches in zebrafish, Braaker et al. find that neuronal activity influences the growth of myelin sheaths along axons by...
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RT @JCellBiol: Shun-ichi Yamashita, Ritsuko Arai, Tomotake Kanki, Satoshi Waguri et al. show that the #mitophagy receptors BNIP3 and NIX ar….
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RT @Agarwal_Shal04: Excited that our work revealing the regulation of PINK1 by ISR pathway, is out now! A new regulatory axis in mitophagy….
science.org
EIF2AK1/HRI kinase negatively regulates PINK1 mitophagy.
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RT @Dpla_: Excited to share our latest paper in @ScienceAdvances! We finally dissected a new pathway for mitochondrial quality control upon….
science.org
Lysosomal uptake of mtDNA controls mitochondrial quality.
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RT @ScienceMagazine: Scientists have identified extensive interactions between T and B cells in the meninges that promote CNS inflammation….
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RT @Nature: Nature research paper: Human de novo mutation rates from a four-generation pedigree reference.
nature.com
Nature - Analysis of more than 95% of each diploid human genome of a four-generation, twenty-eight-member family using five complementary short-read and long-read sequencing technologies provides a...
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RT @MitoPsychoBio: Mitochondria are social organelles and they don’t discriminate. The Mitochondrial Information Processing System (MIPS) c….
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RT @cell_club: Active control of mitochondrial network morphology by metabolism-driven redox state | PNAS
pnas.org
Mitochondria are dynamic organelles that constantly change morphology. What controls mitochondrial morphology however remains unresolved. Using act...
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RT @eLife: Cells have a clever way of flagging damaged DNA so it can be fixed. New research shows they use tiny chemical tags—called m6A—t….
elifesciences.org
Experiments in human cells reveal that a chemical modification of DNA known as m6A directs repair factors to sites of damaged DNA to facilitate their repair.
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RT @ShorterLab: Astrocytic RNA editing regulates the host immune response to alpha-synuclein | Science Advances
science.org
RNA editing and astrocytic inflammatory response pathways may be therapeutic targets for the treatment of Parkinson’s disease.
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RT @fxpimentelm: Happy to share a recent publication from our lab @CBM_CSIC_UAM describing a novel unconventional autophagic pathway that i….
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