📣 Job alert! Our partner group, the Dioscuri Centre for Modeling of Posttranslational Modifications @BioPhysMatt, is seeking a talented individual in the field of #ComputationalBiophysics. Apply ✏️✅! #AssistantProfessor 👉 https://t.co/wP0FP4MJ3o

Very pleased to know that our recent work on hCoV-229E S:hAPN recognition has been highlighted by Nature Communications alongside the work of the newly minted Nobel Prize laureate David Baker

ESMAdam: a plug-and-play all-purpose protein ensemble generator 1. ESMAdam introduces a versatile framework for protein ensemble generation, bridging gaps in high-throughput applications. Leveraging the pretrained ESMFold model and Adam optimization, it excels in efficiency and

This is exciting and opens new avenues for studying the proteasome-ubiquitin system. I am now awaiting K11 ubiquitin-specific probes ;)

Here’s a brief teaser for our latest preprint reporting the first structures of the K11/K48-branched Ub chain bound to the human proteasome: https://t.co/illzy1JT4X Check the full text for more details: https://t.co/D9BMaW7poF Thx to @asibc512 for making this possible!

Our preprint on the first glimpse of how the human proteasome recognizes a K11/K48-branched ubiquitin chain is out. This work reveals a new multivalent ubiquitin binding mode by the proteasome that could serve as priority checkin signal for proteolysis. https://t.co/Sk2ERBDb9B

Call for AMBER is now open and closes on September 6th. Prof. @A_Chacinska is seeking 2 postdoctoral researchers for 2 projects in structural biology, and molecular cell biology and proteomics. Link to the project website: https://t.co/DsUWs1LSeJ @FNP_org_pl @PAN_akademia

How proteins are imported into human mitochondria? Read the latest publication from @A_Chacinska lab. Find out how Klaudia Maruszczak and @PDraczkowski used computational tools to get first architectural insights into these processes. @NCN_PL

Anyone ever needs a command palette in ChimeraX?

Everyone (including me :) is hyped up about the new AF3 today, so let’s mix it up with some other cool science updates from yesterday:

Love it :D @wojtek_pokrzywa have an idea to level up the difficulty: how about adding branched K11/K48 Ub chains into the game scenario? ;D

If you want a brief intro to the latest structural discoveries in mitochondrial protein import, check out our piece in @NatureSMB. Thanks to @AgnieszkaC59642, @MichWasil and whole brilliant team @IMol_Institute for the exciting collaboration. https://t.co/y9Mga4teQi

Even BLAST is dating AI now.

A lot is happening at the interface of AI and cryoEM. It's great to see another method aiming at resolving structural heterogeneity of the sample as this is where the cryoEM really shines.

1/ Very excited to present cryoSTAR, a novel approach for continuous heterogeneity in SPA cryo-EM. In brief, cryoSTAR leverages the prior knowledge from a user-given atomic model to better find dynamics in the final reconstruction. https://t.co/WaaTUnMQRM https://t.co/2SDzNSjPEs

👇🏽 of outstanding importance 👇🏽

New! We’ve just put up a note evaluating the latest, in-development version of AlphaFold (“AlphaFold-latest”). This is a preview - development is still in progress - but performance across a wide range of tasks is striking. https://t.co/28nuVOir9v Highlights in the thread. 1/7

Realizacja zapowiedzi zmian w finansowaniu badań będzie ogromnym ciosem dla nauki (...) Dlatego apelujemy o zachowanie niezależnego i opartego na ocenie eksperckiej sposobu działania @NCN_PL – piszą laureaci grantów #ERC w liście do władz państwa https://t.co/Yu6Bskudoe

IMol director, Prof. Agnieszka Chacińska, has been ranked among the world's best scientists in Biology and Biochemistry area. Congratulations! source: https://t.co/nNiVGDwNb6 Leading Academic Research Portal https://t.co/hFFr7iiwB3… @FNP_org_pl @NCN_PL @PAN_akademia

So does everyone's desktop just look like this after making figures in @UCSFChimeraX , or is this just me? #Cursed #CryoEM (changing the working directory doesn't save them there 🤷‍♀️)