Orhan Efe
@OrhanEfe_
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Nephrologist @MGHkidneys + Vasculitis & Glomerulonephritis Center | Alum @BWHkidney | @ RiellaLab | GlomCon Instructor + Editor | twits=own
Joined January 2020
🚨Our JCI paper is out!🚨 👉Teamwork in designing and showing efficacy of novel mutein IL-2 in transplant models and setting the stage for clinical testing. 👉Many thx to my great mentor @LVRiella @ThiagoJBorges @Visterra_Inc & team! 👉 https://t.co/2WCDj2Tyu7 🧵Our findings👇1/11
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#GlomPedia 🚨 UPDATE ALERT! Dive into the latest update of Membranous Nephropathy chapter ✨ by Drs. @OrhanEfe_ , @nikkonephro , @VBijol and @LauraMarianiMD 👇
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🚨Our paper out🚨 B cell-depletion cause a unique risk of protracted COVID-19 -Often misdiagnosed -Sputum/bronch samples are key -Extended antivirals+IVIG r effective https://t.co/RER6jV4e2v G.Sauvage,J.Chung,A.Jeyabalan, @AlJurdi @BetterCallSeeth K.Laliberte,J.Niles @MGHKidneys
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@MEitingPharmD, Christine R. Marks, Mariesa A.Cote, David Wojciechowski, @kassem_safa, Hannah Gilligan, @jazziup, Nitender Goyal, Marc Raynaud, @AlexandreLoupy @AstridWeins
@MGHKidneys @BWHKidney @GlomCon
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🚨Publication🚨 Tacro to belatacept conversion in proteinuric kidney transplant recipients -pilot singlearm interven. trial in KTRs w high-grade proteinuria -Bela conversion➡️stable eGFR & proteinuria over yrs! https://t.co/iMgXFm9AYZ W @AlJurdi(cofirst),mentor💪@LVRiella,team👇
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The 1159 poster presented by @OrhanEfe_
#nephjc #kidneywk It’s on 👉Rebound and protracted COVID-19 in patients receiving rituximab for autoimmune and glomerular diseases @hswapnil @kidney_boy @KidneyCathy @manasib33 @NephroSeeker
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TH-PO1159 Rebound and Protracted COVID-19 in Patients Receiving Rituximab for Autoimmune and Glomerular Diseases from @OrhanEfe_
#KidneyWk #TeamRodbyLerma #Nephpearls
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It was a pleasure to have @OrhanEfe_ from @MGHKidneys for our Renal Grand Rounds @uofcneph “An Update on ANCA-Associated Vasculitis”
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Congratulations to our amazing fellows! Grateful and humbled for the recognition and being part of your journey🙏🏻 @MGHKidneys @BWHKidney
Congratulations to our amazing group of fellows on graduating! We wish you the very best, you make us proud.
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Our take on a promising strategy to prolong allograft survival 👇🏽👇🏽 @mgh_transplant @LVRiella @OrhanEfe_ @AST_COTS
#AuthorsTake: Prolonged transplant survival in preclinical models: https://t.co/52sZrcIM1X Article: https://t.co/MrboVyCzNV Video: https://t.co/tQ9dY3MmTu
@LVRiella @MGHKidneys
#Immunology
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Please donate if you can. The southernmost state of Brazil is underwater. Many members of the @LVRiella lab are from this place, and we have family members and dear friends who lost everything 😢 @RodrigoGassen @karinarlima @lapeisa
Those outside Brazil can also help the population affected by the climate catastrophe in RS. How to donate: ➡️ EuroZone Standard Chartered Bank Frankfurt Bank Swift: SCBLDEFX Bank Account: 007358304
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Our review of membranous nephropathy is out. We focused on most current understanding and management as well as evolving therapeutics. https://t.co/LgMdLJnSrG
@indianjnephrol @nikkonephro @AnandhUrmila @edgarvlermamd @NWiegley
@GlomCon @MGHKidneys @BWHKidney
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#Commentary: Tipping the balance toward transplantation tolerance: in vivo therapy using a mutated IL-2: https://t.co/NOpDYqr9An
@UPMC Related article: https://t.co/MrboVyCzNV
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A humanized IL-2 mutein expands Tregs and prolongs transplant survival in preclinical models: https://t.co/MrboVyCzNV
@LVRiella @MGHKidneys
#Immunology #Transplantation
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New paper from @LVRiella lab showing the effect of a new engineered IL-2 in the prolongation of graft survival. Congrats @OrhanEfe_ and team for this great work!
🚨Our JCI paper is out!🚨 👉Teamwork in designing and showing efficacy of novel mutein IL-2 in transplant models and setting the stage for clinical testing. 👉Many thx to my great mentor @LVRiella @ThiagoJBorges @Visterra_Inc & team! 👉 https://t.co/2WCDj2Tyu7 🧵Our findings👇1/11
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Since first kidney transplant >50 years ago, little has changed in the approach to prevent rejection after transplant. Excited to share our work changing the paradigm by expanding Tregs& allowing immunosuppression reduction https://t.co/2zVrgtjKzW View details 👇 @mgh_transplant
🚨Our JCI paper is out!🚨 👉Teamwork in designing and showing efficacy of novel mutein IL-2 in transplant models and setting the stage for clinical testing. 👉Many thx to my great mentor @LVRiella @ThiagoJBorges @Visterra_Inc & team! 👉 https://t.co/2WCDj2Tyu7 🧵Our findings👇1/11
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A humanized IL-2 mutein expands Tregs and prolongs transplant survival in preclinical models https://t.co/dfU0kHgR1S
@LVRiella
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🧵11/11 Thanks for reading! Here is the great commentary by Geoffrey Camirand and Fadi G. Lakkis https://t.co/GHbz1dIrTa
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🧵10/11 In sum 👉mIL-2 induced selective expansion of mouse, human, & monkey Tregs and has long half-life 👉mIL-2 increased Tregs functions 👉mIL-2 prolonged skin graft survival in 3 models & promoted antigen-specific tolerance 👉Our study set stage for its clinical testing
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🧵9/11 👉To translate our results to humans, we tested mIL-2 in a humanized mouse model and non-human primates 👉mIL-2 selectively expanded human and non-human primate Tregs
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