Christoph Nitsche
@NitscheLab
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Chemical Biology Laboratory at the Australian National University
Canberra
Joined January 2019
šJust got back from the @ITSASBMB conference where I presented my #Shimadzu Medal Lecture. Thank you to the ASBMB, my #nominators Prof David Tremethick & Ross Hannan, + #lab members & #collaborators for their talent and inspiration š @JCSMR @ANU_Research @scienceANU @ourANU
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@NitscheLab (@ANUChemistry) & colleagues @UOsaka_en open a new chapter for bismuth in chemical biology, introducing bioactive Bi-selenopeptides with exceptional stability. Even human EGF traps two Bi atoms ā removal is nearly impossible! #openaccess š
onlinelibrary.wiley.com
A major obstacle for bismuth peptides and proteins, in which Bi(III) is coordinated by three cysteine residues, is their kinetic lability when challenged with strong metal chelators. By simply...
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Big congrats to @pritha_2107, @MinghaoShang, Kat, @Lani_D1, @UpamaliSajinika and our fantastic collaborators Toshiki and Hironobu @IPR_pr @UOsaka_en for this massive effort on second-generation bismuth peptides and proteins, just published in @angew_chem. https://t.co/gY730T05CP
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Fluorescent Peptide Tracers for Simultaneous Oxytocin Receptor Activation and Visualization (Markus Muttenthaler and co-workers) @univienna @IMBatUQ #openaccess š
onlinelibrary.wiley.com
Illuminating the Oxytocin Receptor: Here we present the development of fluorescent peptide tracers for the simultaneous visualization and activation of the oxytocin receptor, an important G protein...
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Dr Sven Ullrich talks about how RACI opens doors and builds your influence - we swear we didn't make him say any of this šš» š Ready to make your mark? Nominate today and join a network of changemakers. š https://t.co/5kbjegshLa
#RACI #ozchem #NationalAwards2025
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Weāve been dreaming of this type of conjugation chemistry for yearsāand finally, a simple fix to a stubborn problem, all thanks to just a tiny drop of CSā. Minimalist chemistry is the new gold. āØ
@gongchenlab have been hunting for ways to crosslink two different amines for conjugation: turns out that just a drop of CSā in air delivers great results! Read on in their Research Article: ā¢
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šDelighted to share our latest #publication in collab with Dr. Rajendra Karki & colleagues from @SeoulNatlUni. In this @NatureComms paper, we show that #acrolein, a byproduct of our cells but also found in #cigarette smoke, #kills cells & contributes to #inflammation @ourANU 1/3
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Check out our latest paper on @ChemEurJ LateāStage Intermolecular OāPeptidylation Protocol Enabled by Sequential Acyl Transfer on ThiolāIncorporated Threonine Followed by Desulfurization - Sato - Chemistry ā A European Journal - Wiley Online Library
chemistry-europe.onlinelibrary.wiley.com
The late-stage intermolecular O-acylation of the threonine (Thr) side chain was accomplished by reacting thiol-incorporated Thr with a peptide thioester in open air. The thioester, which contained...
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Room temperature, selective C-H activation of arenes with aluminium in seconds!. All you need is an even more reactive aluminyl anion. Check out Fabian and Gareth's latest paper just accepted in @ChemicalScience @ANUChemistry #ozchem
https://t.co/uHVdluiOCL
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Thank you @ANUChemistry for featuring our latest work! We've developed a greener, faster method for in vivo protein labelling ā paving the way for better imaging and biosensing tools Read the article here: https://t.co/eSe3W8jcbh
#GreenChemistry #SyntheticBiology
chemistry.anu.edu.au
A new, easy-to-use method to modify and label proteins quickly, precisely and at low cost has been developed by chemists at The Australian National University.
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Curve the way for the RNA virus replication complex to work. #Chikungunya #virus "Saddle Curvature Association of nsP1 Facilitates the Replication Complex Assembly of Chikungunya Virus in Cells"
biorxiv.org
The replication of positive-sense RNA viruses, including the pathogenic SARS-CoV-1 and -2, DENV, and ZIKV, often takes place in curved cellular membrane compartments of tens to hundreds of nanometers...
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Congratulations to Prof Richard Payne for receiving over $741,000Ā inĀ @NSWHealth CardiovascularĀ Senior Researcher grant funding! Find out more about theĀ CardiovascularĀ Senior ResearcherĀ grants:Ā https://t.co/KUGq1wBoe7
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Hot off the press in @NatureChemistry: Our paper on seed-competent stapled peptides that mimic the core fold of pathological tau! https://t.co/ssOL8tjjfJ Huge congrats to Isaac, Ben, and collaborators in the Jiang and Vidal labs. #PeptideScience #tau
nature.com
Nature Chemistry - Molecules that recapitulate the structure and prion-like activity of misfolded tau hold promise as more relevant models of pathological tau propagation. Now, the macrocyclization...
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Really enjoyed presenting part of my PhD work at @RACInational #MCCB2025 in Darwin, reconnecting with the Australian MedChem and ChemBio community and seeing some crocodiles again too!
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Huge thanks to @Chem_CP for highlighting our work on biosynthesis of nitrile amino acids and fast protein labeling Excited about the new possibilities in chemical biology and live-cell imaging. Thanks @ARC_CIPPS @ANUChemistry #ChemicalBiology #SyntheticBiology #ProteinEngineering
Online now: Biosynthesis of nitrile-containing amino acids for rapid protein conjugation and fluorogenic labeling https://t.co/2rSzNUAIhU
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Pleased to see the review lead by Harry Shanley @Sleebs_Lab @WEHI_research in collaboration with the Gasser Lab @UniMelb on Advances in Anthelmintic Target Identification is now published. https://t.co/nx0xEsjxy9
#mdpiijms via @IJMS_MDPI
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𤩠Check this outš A wonderful piece written by Calo Huang from @JCSMR on the research of @_AbhimanuPandey , @Cyn_Turnbull & Gavin Sutton #immunology #IBD #cancer #medicalresearch š https://t.co/dvVo4p4Lrw
@ANU_Research @ourANU @scienceANU
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Congratulations to @UpamaliSajinika from our lab for receiving the poster prize at the #MCCB2025!
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Fantastic science this morning at #MCCB2025 from @RACI award winners @PScammells and @NitscheLab . The development of bitopic ligands as biased #GPCRs agonists and tricyclic #peptides using cyanopyrine and bismuth chelation. Cool #chemistry
Congratulations to our @RACInational MCCB Division award winners, delivering their lectures this morning in Darwin: @PScammells - Adrien Albert award @NitscheLab - Peter Andrews award ššš #mccb2025
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