Gong Chen
@GongChenLab
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We’ve been dreaming of this type of conjugation chemistry for years—and finally, a simple fix to a stubborn problem, all thanks to just a tiny drop of CS₂. Minimalist chemistry is the new gold. ✨
@gongchenlab have been hunting for ways to crosslink two different amines for conjugation: turns out that just a drop of CS₂ in air delivers great results! Read on in their Research Article: •
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A huge thank you to our amazing guest editors, Masayuki Inoue, Lara Malins @Malins_lab, and Hans Renata @hanzyduzit, for organizing this OL special issue on radical-mediated reactions! Special thanks to Steve Ritter and Matt Saucier for your invaluable support.
Special Issue alert! 🚨 This one is truly •radical•. This VSI highlights the state of the art in radical reaction development and the strategic incorporation of radical reactions in the construction and modification of important molecules.
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Interested in sulfonium ylide chemistry? Don’t miss Biao Xiong's latest Organic Letters paper @JOC_OL on a sleek Cu-catalyzed [3+2] route to 5-CF3-pyrroles, starting from CF3-imidoyl sulfonium ylides and terminal alkynes.
Copper-Mediated Cyclization Gives 5-Trifluoromethylpyrroles:.Practical approach uses CF3-imidoyl sulfoxonium ylides and terminal alkynes.
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HFIP's magic shines again, enabling peptide stapling with alpha-ketoaldehydes through unique imidazolium linkers, outperforming natural “glycation” processes. We proposed HFIP aggregates act as a proton shuttle for efficient deacylative C--C cleavage.
Peptide Stapling by Crosslinking Two Amines with alpha-Ketoaldehydes through Diverse Modified Glyoxal-Lysine Dimer Linkers (Gong Chen and co-workers) @NKU1919
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We are grateful for the swift publication of this work in @NatureSynthesis and the outstanding editorial assistance received!
N-glycoside synthesis, a tough nut to crack, is now approachable with our new light/Cu catalysis method, allowing N-glycosidic bond formation under mild conditions with exceptional water tolerance and unique chemoselectivity. Another fruitful collaboration with MJ Koh @MJKoh87.
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N-glycoside synthesis, a tough nut to crack, is now approachable with our new light/Cu catalysis method, allowing N-glycosidic bond formation under mild conditions with exceptional water tolerance and unique chemoselectivity. Another fruitful collaboration with MJ Koh @MJKoh87.
Now online:. Article by @MJKoh87 @GongChenLab and co-workers @NKU1919 @ChemNUS . N-glycoside synthesis through combined copper- and photoredox-catalysed N-glycosylation of N-nucleophiles. ($).
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Two simple reagents, HCHO and hexafluoroisopropanol (HFIP), unleash new chemical magic! HCHO effectively “sucks” the alpha C-H bond from common alkyl amines in HFIP solvent, enabling hydride liberation without metals or light. It works for complex systems, too.
Formaldehyde-Mediated Hydride Liberation of Alkylamines for Intermolecular Reactions in Hexafluoroisopropanol. @J_A_C_S #Chemistry #Chemed #Science .
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I am deeply humbled and honored to be part of the editor team of Organic Letters. I very much look forward to serving the journal and our organic community☺️.
We are thrilled to announce that Prof. Gong Chen of Nankai University will be joining #OrgLett as an Associate Editor on December 1. Known for his work on metal-catalyzed C-H functionalization and on peptides and oligosaccharides, Gong may soon be handling your manuscript!
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Our lucky streak continued! Formaldehyde can glue amine and guanidine together like a charm :) Thank Xiaosong Xue at Nankai and SIOC for the computational collaboration!
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RT @thiemechemistry: Learn more about #Asymmetric C–H Functionalization in our Thieme Web #Cheminar with Joanna Wencel-Delord (@DelordWence….
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It is a great pleasure to be part of this exciting work on Fe-catalyzed C-glycoside synthesis led by MJ Koh @MJKoh87.
Happy to share our latest work in @NatureSynthesis in collaboration with @GongChenLab. We report a method to synthesize a range of C-glycosides under reductive iron catalysis. @ChemNUS @ResearchFos
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RT @libo019796991: Extendable stapling of unprotected peptides by crosslinking two amines with o-phthalaldehyde .Ou….
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Please check out this work if you are interested in C-glycoside synthesis. The next goal will be alkyl C-H glycosylation :).
Stereoselective Synthesis of C-Vinyl Glycosides via Palladium-Catalyzed C-H Glycosylation of Alkenes (Chen)
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Very excited to have our collobaration work with Sukbok Chang selected as the Synfact of the Month! Thank you @MarkLautens and @thiemechemistry.
❇️ In this Synfact of the Month @MarkLautens and Joachim Loup highlighted the ✨Synthesis of Hydrazides by N–N Coupling ✨ reported by @GongChenLab from @NanKaiUniv 👏 👉
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RT @ChemicalScience: Check out @gongchenlab, Xiaojie Lu et al.'s latest article 😍⬇️. Streamlined construction of peptide macrocycles via pa….
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Simple FeCl2 catalyst enables a very efficient method to make N-N bond. A great collaboration with Prof Sukbuk Chang #KAIST. Please check out our latest research on #nitrene chemistry, published in @NatureChemistry
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Our first study on DNA-encoded library synthesis. The Pd-catalyzed S-arylation chemistry is very effective and robust under biocompatible conditions. Many thanks to Xiaojie Lu at SIMM for a great collaboration!.- now published in Chemical Science
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Very proud of this chemistry 🤪.
Cooperative Stapling of Native Peptides at Lysine and Tyrosine or Arginine with Formaldehyde (Chen)
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RT @ChemicalScience: NEW in @ChemicalScience 📢 A Rapid and Sensitive Method for Chiroptical Sensing of α-Amino Acids via Click-like Labeli….
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