The Otaka Lab.
@otaka_lab
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徳島大学薬学部・大学院薬科学教育部 機能分子合成薬学分野（大髙グループ）Otaka Lab. (Tokushima University)
Tokushima
Joined August 2021
Check out our latest paper on @ChemEurJ.Late‐Stage Intermolecular O‐Peptidylation Protocol Enabled by Sequential Acyl Transfer on Thiol‐Incorporated Threonine Followed by Desulfurization - Sato - Chemistry – A European Journal - Wiley Online Library
chemistry-europe.onlinelibrary.wiley.com
The late-stage intermolecular O-acylation of the threonine (Thr) side chain was accomplished by reacting thiol-incorporated Thr with a peptide thioester in open air. The thioester, which contained...
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RT @wakatepeptide57: 本日、第57回若手ペプチド夏の勉強会のホームページを公開しました。情報は、随時更新していきますので、ホームページおよびXをご確認下さい。.
sites.google.com
若手ペプチド夏の勉強会について
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Professor Nitche @NitscheLab joined our research lab trip and we had a wonderful time exploring the scenic wonders of Shikoku!
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RT @NitscheLab: Thank you very much Prof. Otaka and group for hosting me @TokushimaUniv and showing me the beautiful island of Shikoku. htt….
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Check out our latest paper on Bioorganic & Medicinal Chemistry Letters Cysteinylprolyl ester-mediated drug release from a lipid–drug conjugat.
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Check out our latest paper on @ChemEurope.Sulfoxide‐Mediated Cys‐Trp‐Selective Bioconjugation that Enables Protein Labeling and Peptide Heterodimerization - Kobayashi - ChemistryEurope - Wiley Online
chemistry-europe.onlinelibrary.wiley.com
A tryptophan selective modification was achieved that utilizes S-Acm cysteine sulfoxide under mildly acidic conditions in the presence of magnesium chloride. An optimum condition in an ionic liquid...
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We are excited to share our publications about the use of Lossen rearrangement of Glycyl hydroxamic acid in a peptide sequence, DOI: 10.1021/acs.orglett.4c01126 and DOI: 10.1021/acs.orglett.4c01685.
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We are excited to share our publications about the use of Lossen rearrangement of Glycyl hydroxamic acid in a peptide sequence, DOI: 10.1021/acs.orglett.4c01126 and DOI: 10.1021/acs.orglett.4c01685.
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Check out our latest paper on @JOC_OL. Synthesis of N-Glyoxylyl Peptides Enabled by a Lossen Rearrangement-Induced Intramolecular Redox Reaction of N-Terminal Glycyl Hydroxamic Acid | Organic Letters
pubs.acs.org
An oxidant-free approach to the synthesis of N-glyoxylyl peptides has been developed that utilizes the Lossen rearrangement of the N-terminal glycyl hydroxamic acid residue. The synthesis proceeds...
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Check out our latest paper on @ChemEurope Advanced Insulin Synthesis by One‐pot/Stepwise Disulfide Bond Formation Enabled by S‐Protected Cysteine Sulfoxide - Hidaka - Chemistry – A European Journal - Wiley Online Library
chemistry-europe.onlinelibrary.wiley.com
The reaction of S-protected cysteine and the corresponding cysteine sulfoxide with increasing acidity of the reaction allowed one-pot/stepwise disulfide formation for insulin synthesis. The stepwise...
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'Advanced Insulin Synthesis by One-pot/stepwise Disulfide Bond Formation Enabled by Acid-activated S-Protected Cysteine Sulfoxide in the Presence of Chloride Anion' (doi: 10.26434/chemrxiv-2024-jg5z3)
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We are excited to share our working paper, titled 'Advanced Insulin Synthesis by One-pot/stepwise Disulfide Bond Formation Enabled by Acid-activated S-Protected Cysteine Sulfoxide in the Presence of Chloride Anion', which has been posted on the ChemRxiv Archive.
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We are excited to share our recent achievement: a target for CXCL14 chemokine was identified using a chemoproteomic strategy with synthetic CXCL14-based photoaffinity probes that is synthesized by our SEAlide chemistry.
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We are excited to share our working paper, titled 'Sulfoxide-mediated Cys-Trp-selective bioconjugation that enables protein labeling and peptide heterodimerization', which has been posted on the ChemRxiv Archive (doi: 10.26434/chemrxiv-2024-tkv7w-v2).
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第60回ペプチド討論会で修士2年の林隼矢君がポスター賞を受賞しました。. Junya Hayashi won the Poster Presentation Award at the 60th Japanese Peptide Symposium.
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第60回ペプチド討論会で大髙教授の日本ペプチド学会 学会賞の授賞式が行われました。. Professor Otaka received the Japanese Peptide Society (JPS) Award at the 60th Japanese Peptide Symposium.
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滋賀県で11月8日～10日に開催された第60回ペプチド討論会に参加してきました。. We participated in the 60th Japanese Peptide Symposium held November 8-10 in Shiga Prefecture, Japan.
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Commemorative photo of Professor Yasuhiro Kajihara and graduate students (Kobayashi, Hayashi, and Hidaka) who participated in IPS held in Brisbane. #AusPeptide2023
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Commemorative photo of Professor Lara Malins and graduate students (Kobayashi, Hayashi, and Hidaka) who participated in IPS held in Brisbane. #AusPeptide2023
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Commemorative photo of Professor Fernando Albericio and graduate students (Kobayashi, Hayashi, and Hidaka) who participated in IPS held in Brisbane. #AusPeptide2023
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