Niklas Mattsson-Carlgren
@NiklasMattsson4
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Research on Alzheimer's disease and other neurological diseases
Sweden
Joined August 2019
Check out this paper, a collaboration between Lund University and UCSF Memory and Aging Center, where we show that CSF biomarkers have very high accuracy for autopsy confirmed Alzheimer's disease https://t.co/mjMnr9nee5
@OskarHansson9 @RabLab_UCSF @MultiparkL @biofinder_study
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Enjoy this podcast episode about our recent Neurology paper on CSF biomarkers in autopsy confirmed neurodegenerative diseases! https://t.co/zvVsymC4Di
@biofinder_study @OskarHansson9 @RabLab_UCSF
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Does #Abeta38 affect the risk of #AD ? @alzforum discusses interesting findings by Nicholas Cullen, @NiklasMattsson4, @SebastianPalmqv and @OskarHansson9. #neuroscience #biomarkers #alzheimersdisease @Medfak_LU
People with early Alzheimer's are less likely to progress to dementia if they have a lot of Aβ38. Should γ-secretase modulators be revived? #Alzheimersdisease @lunduniversity
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Cerebrospinal Fluid Biomarkers in Autopsy-Confirmed Alzheimer Disease and FTLD. Class II evidence. https://t.co/pxpYm1hfIo
@NiklasMattsson4 @grinberg_t @RikOssenkoppele @ajehrenberg @SalvoSpinaSF @JulioCRojas10 @relajoie @leoiacca @OskarHansson9 @AlbaLanguage @RabLab_UCSF
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Cerebrospinal Fluid Biomarkers in Autopsy-Confirmed Alzheimer Disease and FTLD. 101 patients w/ CSF & neuropath data. https://t.co/pxpYm1hfIo
@NiklasMattsson4 @grinberg_t @RikOssenkoppele @ajehrenberg @SalvoSpinaSF @JulioCRojas10 @relajoie @leoiacca @OskarHansson9 @RabLab_UCSF
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Research in progress in one of our research groups. @NiklasMattsson4 @roman_sattarov
#researchinprogress #phdlife #neuroscience #operetta #experimentalresearch #biomarkers #inducedneurons
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Findings from @biofinder_study reveal genetic influence on longitudinal #cognitivedecline in early stages of #AD, partially mediated by #Abeta pathology. @SciReports @SebastianPalmqv @OskarHansson9 @NiklasMattsson4 @Medfak_LU
https://t.co/SRHZYVWfO5
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80 % of the world’s #HighlyCitedResearchers at #lunduniversity comes from MultiPark. Congratulations to @OskarHansson9 @sara_linse and @NiklasMattsson4. And to @BrundinPatrik, previously initiating MultiPark. @Medfak_LU #Clarivate
https://t.co/x6UU5o4nBn
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In this new paper https://t.co/cLMMI0Jn7W, we show how changes in levels of soluble phosphorylated tau depend on deposition of both beta-amyloid and tau aggregates in the brain in Alzheimer's disease @biofinder_study @EmboMolMed
Our recent paper shows that plasma pTau is mainly related to amyloid plaques in early disease and tau tangles in later disease stages. That is, soluble pTau is associated with both pathologies and not simply a marker of any of these pathologies per se.
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Our recent paper shows that plasma pTau is mainly related to amyloid plaques in early disease and tau tangles in later disease stages. That is, soluble pTau is associated with both pathologies and not simply a marker of any of these pathologies per se.
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Great collaboration evaluating plasma pTau in two cohorts characterized using either neuropathology (Banner) or PET (BioFINDER). Especially thanks to @NiklasMattsson4. @MultiparkL @lunduniversity
Our recent paper shows that plasma pTau is mainly related to amyloid plaques in early disease and tau tangles in later disease stages. That is, soluble pTau is associated with both pathologies and not simply a marker of any of these pathologies per se.
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I am delighted to share our latest blood biomarker work published in @alzassociation. We investigated baseline & longitudinal #pTau, #NfL, #GFAP, #tTau, #Aβ to predict diagnosis & grey matter changes in individuals not predetermined by CSF/imaging. https://t.co/PJ2ldGKwTl 1/n
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In this proteomics study https://t.co/aYcEtHOwIE we found evidence of accelerated inflammatory ageing in Alzheimer's disease, supporting the view that inflammatory pathways are critically involved in Alzheimer's disease @biofinder_study @LuWcmm @OskarHansson9
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Very happy to present this work on Time Between Milestone Events in The Alzheimer's Disease Amyloid Cascade https://t.co/gcbCcuvhG1. One key finding was that changes in tau started quite early. Perhaps DMTs must be initiated prior to significant Aβ pathology? @biofinder_study
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Plasma phosphorylated tau (P-tau) correlate with imaging measures of brain atrophy over time in AD! Perhaps repeated blood tests can track atrophy, both in clinical practice and in drug trials, to find therapies that reduce degeneration? https://t.co/rHqyBtPylg.
@biofinder_study
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In this paper, we demonstrate how plasma and CSF biomarkers can be used for individualized prognostication of cognitive decline due to Alzheimer's disease. We hope that this will improve patient management, help patients and families, and speed up drug trials for new therapies.
4y prognosis of cognitive decline and #dementia due to Alzheimer’s disease in patients with mild cognitive impairment based on a combination of tau and neurodegeneration https://t.co/QCNzzyxyZG
#PlasmaBiomarkers @OskarHansson9, @NiklasMattsson4, @SebastianPalmqv, @biofinder_study
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Plasma P-tau depends on both beta-amyloid and tau pathology in Alzheimer's disease. Early in the disease, plasma P-tau may be increased in response to beta-amyloid pathology. In later disease stages, plasma P-tau is associated with tau aggregation in the neocortex.
What AD pathologies are measured by plasma P-tau? In this preprint, using both neuropathology and PET, we show that plasma p-tau217 levels are predicted by both amyloid plaques and tau tangles.
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Excellent review about #APOE ε2: "Protective mechanism and therapeutic implications for #Alzheimer’s disease", https://t.co/79KYDIb4Nj. Can we develop therapies that mimic APOE ε2 effects to prevent/delay/cure AD?
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New data from the @biofinder_study suggest that enlarged perivascular spaces, which previously have been implicated in AD+pathological #aging, are related to small vessel but not #Alzheimer disease or cognition: https://t.co/yxLbyCis3e
@GreenJournal @OskarHansson9 @NiklasMattsson4
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You could pay every American $3,000 on the money that the wealthiest 0.0002% have *increased* their wealth by during the pandemic -__-
The real looting in America is 644 billionaires becoming $931 billion richer during a pandemic, while Republicans continue to deny 25 million+ unemployed Americans the $600/week they need to pay for rent & put food on the table. We need an economy that works for all, not the 1%.
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