C. acnes is the most abundant bacterium on human skin. But what if we could make it the smarterst? 🦠✨ In our new @cellsystems study, we programmed C. acnes to actively protect the skin for therapeutic applications! 🛡️ https://t.co/hb9JjqXyMs

🧬✨ César de la Fuente en Ágora ✨🧬 El investigador gallego, catedrático en la Universidad de Pensilvania y líder del Machine Biology Group, nos cuenta cómo su equipo utiliza machine learning para encontrar nuevos antibióticos. Explorando un mundo poco conocido: las arqueas,

High-resolution metagenome assembly for modern long reads with myloasm https://t.co/lGIxJcirLX #biorxiv_bioinfo

✨ Over the coming weeks, get to know better the members of our society with our #EUSynBioMembers series! This week we're introducing our Board members — who they are, what they do inside and outside the lab, and what drives their interest in #SynBio! 👉 https://t.co/u3vfh8nHQk

🚨A great collaborative effort on skin microbiome engineering published today in @CellSystemsCP 🙏Very thankful to all coauthors - @Nevotii @marcguellc @ellenbogaard @icvaraA @LedesmaAmaro and many others! 👇Nice summary by @Nevotii below 👇👇👇

Great work from a great team 👇🏼👇🏼 Lucky to have contributed! A great milestone for #EngineeringBiology showcasing the importance of non-conventional organisms in #biotech

Great highlight of our paper this week in @CellSystemsCP in context together with @MatthewWChang incredible work for bacterial brain delivery. Non-model bacteria for the win!

If you reached until here I guess you are as excited about C. acnes as we are! All our plasmids are available in @Addgene and @SEVAplasmids for you to play. We are also happy to collaborate to advance C. acnes! All the info in our paper👇 https://t.co/hb9JjqXyMs

Here is a video of our @SKINDEV project if you want to know more of what we are cooking in the background 😉 https://t.co/Pp7q3QZiu1

Also thanks to our great skindev collaborators @ellenbogaard #Patrick @radboudumc and @icvaraA @LedesmaAmaro from @imperialcollege . Also, thanks to our great editor #ErnestoAndrianantoandro for all his enthusiasm and guidance over the publication. Thank you all very much!!

Of course, this work would not have been possible without the funding from the @EITeu @SKINDEV_EU, the mentorship of @marcguellc and the efforts from the team at @Synbio_Lab_UPF @UPFbiomed @the_prbb (with special thanks to @santosmoreno_j!)...

Very nice Guille, so what’s next? We hope to have demonstrated the potential of C. acnes to become the best microbial chassis for synbio applications in the skin and we are working to validate this in more realistic models so stray tuned!

For therapeutics, we implemented a UV-damage kreatinocyte model and see if the supernatant of an engineered C. acnes producing a recombinant antioxidant protein could protect the cells. Turns out it reduced significantly the ROS levels in the UV exposed keratinocytes!

For biocontainment, we focused on targeting key metabolic genes so C. acnes would only survive if we topically supplement the missing amino acid. Since knocking out genes is still challenging in this skin non-model bacterium, we turned to #CRISPRi to quickly screen auxotrophs.

How did we apply these tools? We focused mainly on two objectives: 1️⃣ Biocontainment strategies for safely deploying C. acnes in human skin 🛑🦠 2️⃣ A proof-of-concept therapy to combat UV-induced oxidative damage ☀️💥

Thus, we have focused in engineering C. acnes. Now, we offer a whole set of tools for making C. acnes smarter with: 🔨 Modular and optimized plasmid 🔨 Basic expression tools: promoters, RBSs, terminators… 🔨 CRISPRi 🔨 Natural and synthetic inducible systems

Although C. acnes has a bad rep bc *some strains* are associated with acne, it’s actually the most abundant #skin commensal for #synbio: ✅ Colonizes the skin follicle where the skin is the thinnest ✅ Low turnover ✅ Genetically stable ✅ Engrafts after topical application

✨⁣ 𝗠𝗲𝗲𝘁 𝘁𝗵𝗲 2025 𝗘𝘂𝗦𝘆𝗻𝗕𝗶𝗼𝗦 𝗦𝘁𝗲𝗲𝗿𝗶𝗻𝗴 𝗖𝗼𝗺𝗺𝗶𝘁𝘁𝗲𝗲!⁣ ⁣ We are thrilled to introduce our team of passionate scientists dedicated to advancing #SyntheticBiology across Europe! 👇Get to know them: https://t.co/lRvEKAzBb4 ⁣ #SynBio #EUSynBioS

Guillermo Nevot is giving an amazing talk at #SynBYSS @Nevotii

#Pseudomonas fans: this is THE course you've always dreamed of!😃Advanced #SynBio & #Metabolic #Engineering of Pseudomonas organized by @vdlorenzo_CNB & yours truly. A fantastic faculty & trainer roster is ready to host you at @CSHL Suzhou September 2025 https://t.co/h7gOIHzW2i