Jacob Hooker
@jmhooker
Followers
932
Following
2K
Media
75
Statuses
1K
Chemist turned neuroscientist. @MGHMartinos @MGHImaging. Editor-in-chief of @ACSChemNeurosci.
Boston, MA
Joined November 2013
Our latest paper describes automated synthesis and preclinical imaging of a novel [18F]Fluorolidocaine analog via sequential C-H radiolabeling and is out in @rsc_medchem. Congrats @MadisonFrazier1 (1st paper!) @jays_wright @afallenbrooks. Read it here: https://t.co/9KTfc2r56Z
1
5
31
@Eikonizo is excited to be in Philly for the @alzassociation #AAIC24. A great opportunity to learn from and meet with some of the best and brightest in dementia research. If you see our CEO @RickLundberg, be sure to stop and say hello!
0
5
5
Wow. The Harris team are out of the blocks in lightening quick time with this superb ad
850
11K
54K
📢Stay up to date with the latest📢 This new collection of #ACSChemNeuro research joins the discussion around #MDMA as a potential breakthrough therapy Read the latest research ➡ https://t.co/PiwSg7FvIJ
0
2
4
And that's a wrap on #BIO2024! Our CEO, @RickLundberg, spent a busy few days meeting with #biotech & #pharma industry partners and investors while still making time to enjoy some of the sights in beautiful San Diego.
0
6
5
📢New collection of #ACSChemNeuro research as the FDA is expected to announce a decision on a new treatment involving #MDMA today ⏰ Read the latest research ➡ https://t.co/MiFPxVyOnt
0
4
6
FDA Advisory Committee votes against recommending Lykos' #MDMA treatment for PTSD Read our latest MDMA research here ➡ https://t.co/iFVKFwAa7U
0
2
3
@ACSChemNeurosci @zenbrainest Super interesting discussion about expectancy bias… check out
pubs.acs.org
1
1
4
Overall, I thought the discussion was less focused on the tremendous unmet need. Maybe I’m a bit too cavalier, but I certainly felt the benefits outweigh the risks (with plenty of guardrail caveats).
@jmhooker @zenbrainest want to kick off the discussion?
0
0
1
Fascinating discussions online today surrounding the FDA's consideration of a new #MDMA treatment for PTSD 🤔 When is a double-blinded study not enough? How can you blind for a treatment that includes such pronounced and well-known effects? Let us know what you think! ⬇
1
4
4
Today the world can watch a film that has been called “the best movie I have seen in 30 years.” For Love & Life: No Ordinary Campaign is now streaming on @PrimeVideo. After you watch the documentary, please review it on the Amazon page for the film. https://t.co/FO3gvK8Bhj
amazon.com
A deeply moving documentary illustrating the transformative power of love, hope and activism. The film follows Brian Wallach and his wife Sandra after his ALS diagnosis at age 37. Anchored by a deep...
163
403
3K
Whoo hoo! Major paper now out in @science : "AlphaFold2 structures guide prospective ligand discovery" Collaboration with @RothLabUNC @BShoichet Skiniotis, Kruse, @EnamineLtd
2
17
88
An orangutan in Sumatra surprised scientists when he was seen treating an open wound on his cheek with a poultice made from a medicinal plant
nature.com
Nature - The Sumatran orangutan used a plant known to humans for its medicinal qualities.
20
529
2K
Neuroimaging, blood proteomics, and health data from 30 military personnel show that increased exposure to explosive blasts was associated with structural and functional brain alterations and a decrease in health-related quality of life. In PNAS: https://t.co/lCOTXM1S0i
0
13
18
Really excited to share the hard work of a killer team. This project was a long time in the making and hit the COVID shutdown timeline and “penalty” but the team saw it through and it’s really great science. @ACSCentSci
pubs.acs.org
Cyclooxygenase-2 (COX-2) is an enzyme that plays a pivotal role in peripheral inflammation and pain via the prostaglandin pathway. In the central nervous system (CNS), COX-2 is implicated in neurod...
0
2
16
Multidisciplinary team at @MGHMartinos @MGH_CNTR studied 30 active-duty U.S. Special Operations Forces: https://t.co/hcqjtddoP6 Increased blast exposure was associated with structural, functional and neuroimmune changes in the brain detected by MRI & PET: https://t.co/bfm895SVII
0
7
22
Impact of Repeated Blast Exposure in Active-Duty U.S. Special Operations Forces: https://t.co/lA3rqmi8MX We thank the 30 SOF participants, who bring the military one step closer to a diagnostic test for repeated blast brain injury. @MGHNeurology @MGHMartinos @MGH_CNTR
0
10
27
Nature research paper: Bitter taste receptor activation by cholesterol and an intracellular tastant
nature.com
Nature - Cryo-electron microscopy structures of the type 2 taste receptor TAS2R14 in complex with Ggust and Gi1 identify cholesterol as an orthosteric agonist and the bitter tastant cmpd28.1 as a...
2
40
173
Wow!! De novo design of drug-binding proteins with predictable binding energy and specificity | Science
science.org
The de novo design of small molecule–binding proteins has seen exciting recent progress; however, high-affinity binding and tunable specificity typically require laborious screening and optimization...
2
36
139