Moghaddam Lab
@MoghaddamLab
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Congratulations to all awardees including our lab mate Merridee Lefner #EBPS2025
Congratulations to this year's cohort of travel awardees. The committee had an incredibly hard job with over 100 applications! We look forward to seeing you all in Spain next month. Attendees, the data blitz highlighting the awardee's work is on Day 1 at 15:10. #EBPS2025
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New work from our lab demonstrates that when contingencies shift from punishment to reward, flexible behavior is related to increases in VTA GABA (and not dopamine!) neuron activity ๐
New lab paper by Merridee Lefner identifying a novel role for VTA GABA neurons in behavioral flexibility GABA, but NOT dopamine, neuron activation correlates with behavior when cues unexpectedly shift from predicting punishment to predicting reward https://t.co/qig7j7ikUi
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๐ new preprint Super excited about this data because almost 30 years ๐ฑafter our series of papers on dopamine, NMDA, and schizophrenia came out, we may have mechanistic insight about latent presentation of psychosis and abnormalities in dopamine dynamics in schizophrenia ๐งต1/n
Reductions of Grin2a in adolescent dopamine neurons confers aberrant salience and related psychosis phenotype https://t.co/ppaVjN7ctm
#biorxiv_neursci
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Congratulations to @bita137 on receiving the #ACNP2023 Dolores Shockley Diversity and Inclusion Advancement Award from @ACNPorg You can watch Dr. Moghaddam's acceptance video here: https://t.co/9ouJCcrwDi
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New preprint from the @MoghaddamLab No eXplanation of the data on this site so you just have to read the paper to learn how different cortical regions change their activation of reward-motivated actions in a model of learned anxiety
biorxiv.org
Background Anxiety is a common symptom of several mental health disorders and adversely affects motivated behaviors. Anxiety can emerge from associating risk of future harm while engaged in goal-gu...
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Congratulations to @merridiesel for receiving her F32 on the first submission awarded by @NIDAnews ๐ Keep an eye out for her work focusing on top-down regulation of flexible behavior!
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Huge congratulations to our lab mate @Dr_Bediya for winning the @ACNPorg travel award!!
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For #MentalHealthAwarenessMonth, Dr. Alejandro Torrado Pacheco discusses his latest research and the potential therapeutic role for psilocybin on the @TheLabRatChat podcast:
open.spotify.com
Lab Rat Chat ยท Episode
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Dr. Bita Moghaddam says findings bolster the case for #psilocybin use in conjunction with clinical treatment for conditions like depression and post-traumatic stress disorder. @bita137
https://t.co/x9XwdmfMg3
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๐Latest paper from the lab led by Dr. Torrado Pacheco ๐๐
Now online in @npp_journal from Alejandro Torrado Pacheco, @bita137 and colleagues - "Acute psilocybin enhances cognitive flexibility in rats" @OHSUNews
https://t.co/hBMW2aDDE5
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New work from the lab led by the incomparable Dr. Torrado Pacheco with contributions from rotating student Randall Olson (from @DrAtheirAbbas lab) and RA Gabi Garza (now grad student @UMich ๐)
4/n Consistent with this idea, we find that psilocybin robustly improves cognitive flexibility in rats using a task where animals switched multiple times between previously learned strategies in response to uncued changes in the environment
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Neuroscience of mental health outreach at its best! Excellent turnout and wise words from @MoghaddamLab member Michelle Kielhold
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Beautiful work led by lab alumni @SweytaLohani
New work with @mjhigley lab is out! Spearheaded by postdocs @SweytaLohani and Andrew Moberly, in collaboration with @HBenisty and @yulonglilab. 2-color imaging of the relationship between ACh and neural activity across states in the awake cortex in ๐ญ.
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Beautiful work led by lab alumni @SweytaLohani
New work with @mjhigley lab is out! Spearheaded by postdocs @SweytaLohani and Andrew Moberly, in collaboration with @HBenisty and @yulonglilab. 2-color imaging of the relationship between ACh and neural activity across states in the awake cortex in ๐ญ.
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I am not attending #SfN2022 but @MoghaddamLab is well represented. Go check out the posters!!
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What a privilege (and fun experience) to talk IRL to a packed house of several thousand๐ฑabout the work of @MoghaddamLab
#ECNP2022
Powerhouse & provocative keynote from @bita137 on the evolution of glutamate hypothesis of schizophrenia & utility of animal models- Great way to open #ECNP2022
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New paper from our lab: during learning of a punishment risk task, action execution and reward (but not the punisher) influences activity in dmPFC & VTA, with diazepam effects on neural activity. Work led by David Jacobs, Madeleine Allen & @juncholp
https://t.co/37yAppsMM2
elifesciences.org
A novel approach to studying anxiety reveals that learned anxiety and diazepam treatment have unique roles on prefrontal cortex and ventral tegmental area activity.
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