Abhay Mishra
@MishraAbhayaK
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EBZ adds a new dimension to biomolecule functionalization with hypervalent iodine, an amazing collaboration between Abhaya @MishraAbhayaK and Ilias @IKoutsopetras at the Chaubet group! @ChaubetGuilhem @BFC_UMR7199 just accepted @ChemEurJ @ERC_Research
https://t.co/Kc27ytlbni
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Further nice career steps for @LCSOLab alumni recently: Abhaya Mishra @MishraAbhayaK became senior scientist at Charles River Laboratories Nina Declas @NDeclas started as principal scientist at Syngenta Ashis Das @ashisdas283 became senior scientist at Pharmaron UK Ltd
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Second, the peptide-EBXs from Xingyu @Xingyuu_Liu (previously on @ChemRxiv ) also accepted @angew_chem ! A huge work @ERC_Research including thiol functionalization, photocatalyzed macrocyclization and binding studies with Heinis group @EPFL_CHEM_Tweet
https://t.co/EYKEYx5Q1a
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The work of Nieves @Nieves_P_R @NCCR_Catalysis on the Cu-catalyzed enantioselective 3-component reaction of nucleophiles, diazo compounds and EBX reagents is now accepted @angew_chem ! https://t.co/yKaUNLVm1r
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Up to now, we used EBX to modify peptides, but now Xingyu @Xingyuu_Liu installed EBX on peptides for bioorthogonal transformations! Now as preprint @ChemRxiv
https://t.co/pJ2o8yxF6B Don't hesitate to contact us if you want to try some of these reagents in your research!
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This week Jerome Waser @LcsoLab visited us as a Gale Foundation Breakthrough Researcher giving an enriching workshop for graduate students and postdocs as well as a spectacular seminar.
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Stephanie @steph_ge_amos Julien, Nina @NDeclas and Eliott @LeDu_Eliott have prepared a short summary in French for "l'actualité chimique": @reseauSCF Un point sur: "L'iode hypervalent: un outil pour l'inversion de polarité de l'alcyne" https://t.co/j1wDl8vCWq
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New way to functionalize peptides/proteins : Nina @NDeclas now developed the first method for tyrosine functionalization with EBXs, with already first applications with @matile_group and @PStallforth (more in the thread) now available @ChemRxiv
https://t.co/KY0scozFws
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Take a look at Stefano's work who developped an enantioselective (4+3) Annulation of Cyclopropanes and Azadienes for the synthesis of Azepanones! @angew_chem @EPFL_CHEM_Tweet
https://t.co/Ca1ewU8lxB
onlinelibrary.wiley.com
Azepanones are important and widespread seven-membered heterocycles, but their synthesis is challenging. A convergent method to access these scaffolds was developed relying on a (4+3) annulation...
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The ultimative EBX synthesis by Julien: it is so efficient that you can directly perform alkynylation reactions in the same pot without need for isolation or purification now available @JOC_OL
pubs.acs.org
Ethynylbenziodoxolones (EBXs) are commonly encountered reagents for the electrophilic alkynylation of nucleophiles. Herein, we report a one-pot, two-step process for EBX generation and their direct...
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Really exciting times ahead! Looking forward to my new EiC role @HelvChimActa with Jérôme Wasser @LcsoLab ! Thank you so much to Jeff @bode_lab and Christophe @CoperetGroup @ETH_en for all your excellent work over the past six years! @SwissChemistry
We are delighted to introduce the new EiC of @HelvChimActa: Jérôme Waser @LCSOLab @EPFL_Chem_tweet and Eva Hevia @EvaHeviaGroup
@DCBPunibern. We look forward to working together with them in the new year! @SwissChemistry.
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You want to learn more about the late stage functionalization of peptides and proteins with hypervalent iodine reagents? Have a look at the mini-review of Emmanuelle and Elija just accepted @angew_chem ! https://t.co/CwlVDr151Q
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How many languages can you say goodbye in? #LcsoChallenge #ChemInclusion @EPFL_CHEM_Tweet @EPFL_en Wish you all the best for the future @MishraAbhayaK
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Be sure to read this article from @HelvChimActa titled "Inhibition of Thiol-Mediated Uptake with Irreversible Covalent Inhibitors." Read here: https://t.co/IdruJ90f16
#OpenAccess (@EPFL_CHEM_Tweet @LcsoLab @matile_group @unige_en)
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In Xie's work, 4CzIPN was also found as an optimal catalyst. In our preprint, we showed that direct activation of PhEBX with Kessil lamps was possible, alleviating the need for the photocatalyst. Final publication should be out soon with more details. https://t.co/vWLU1zyGBh
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How to access 1,2-, 1,3- and 1,4- diamines with orthogonally protected amino groups using the same strategy ? Look at the last results of Ming-Ming @mingming0629 and Tin @TinVTNguyen1 using alkenes/strained rings azidation just published @J_A_C_S
https://t.co/gOL6p3CWDX
pubs.acs.org
Diamines are essential building blocks for the synthesis of agrochemicals, drugs, and organic materials, yet their synthesis remains challenging, as both nitrogens need to be differentiated and...
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Look at the first Cu-catalyzed multi-component reaction of EBX, diazo compounds and anilines developed by Nieves @Nieves_P_R @NCCR_Catalysis and Guillaume and now published in JOC @JOC_OL
https://t.co/glsW4c2gdN
pubs.acs.org
The gem-aminoalkynylation of fluorinated diazo compounds catalyzed by a simple Cu(I) salt is described. This three-component reaction allows the synthesis of propargylic amines with broad functional...
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@LcsoLab @MishraAbhayaK Thank you for publishing with us.
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Amphiphilic Iodine(III) Reagents for the Lipophilization of Peptides in Water (Waser) @LcsoLab @MishraAbhayaK #openaccess
https://t.co/1B2JJyPujW
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