Ming Li
@MingLiLab
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Member, Memorial Sloan Kettering Cancer Center Views expressed are not affiliated with my employer.
New York, NY
Joined July 2011
High rate ATP production accounts for the Warburg Effect, perhaps in support of energy-demanding processes such as PI3K signaling in effector T cells
Excited to share our new paper led by @mattabolite in collaboration with Saharon Rosset showing that the Warburg Effect is the result of faster ATP production by glycolysis than respiration. A 🧵... 1/n
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Congrats to Andrea @SchietingerLab for the very well deserved @CancerResearch Frederick W. Alt Award! Brilliant science for cancer cure!!
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Now online! Dynamic allostery drives autocrine and paracrine TGF-β signaling
cell.com
Genetically engineered mice survive with only autocrine but no paracrine TGF-β1 signaling. Structural and functional studies reveal a mechanism for TGF-β1 autocrine signaling driven by conformational...
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Glad to share our review article @AnnualReviews on tissue-resident innate and adaptive lymphocytes in cancer. Defining their identities and sensing mechanisms shall guide targeting such prewired and priming-dependent defense responses for cancer therapies. https://t.co/pg5DmGsLcN
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28 cancers are now treatable with immunotherapy, thanks to the work of the Cancer Research Institute. Explore our Impact Report, and discover how CRI is transforming the lives of cancer patients on a global scale: https://t.co/AD6s5fn0F8
#CancerResearch #Immunotherapy
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Thanks to @MSKCancerCenter for covering it!
MSK's Dr. Ming Li (@MingLiLab) discusses how his lab is working to harness the power of the immune system against #cancer — including a new paper just out in @ImmunityCP. https://t.co/ip85BZJJSh
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Deeply missing Albert. He is such as an exemplary scholar.
Albert Bendelac (1956-2023)
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Reprogram tumor-associated macrophages to outcompete endothelial progenitor cells and suppress tumor neoangiogenesis. Excited to share our new study @ImmunityCP by brilliant @miahdo1 , Wei Shi, and @CancerResearch fellow @LiangliangJi and collaborators!
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Growing bigger had a survival advantage for non-minimal cells and not growing bigger had a survival advantage for minimal cells.
A mind-blowing paper has come out today in @Nature In 2016, JC Venter Institute scientists trimmed a bacterial genome to its barest minimum required for life to synthesize what they called a "minimal genome" ( https://t.co/CNDeaZUmYd). Today, a group of scientists from
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Excited to introduce scKINETICS, an algorithm for joint inference of gene regulatory mechanism and cellular velocity, co-developed by the amazing duo of @CassBurdziak and @juuuulianaar
https://t.co/6WfAtn6HT2
academic.oup.com
AbstractMotivation. Transcriptional dynamics are governed by the action of regulatory proteins and are fundamental to systems ranging from normal developme
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Reprogram tumor-associated macrophages to outmatch cancer cell competition. Excited to share our new study @Nature by brilliant @CancerResearch fellow @XianZhang2016 and collaborators! https://t.co/koxdb9Nmlr
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Our lab's latest paper on peripheral tolerance mechanisms in skin is out now in @Nature. Congrats to @martinadamo for leading this and thanks to collaborators from @KrishnaswamyLab and @yalederm. https://t.co/GV0aFrfHJM
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Celebrating cancer immunology and immunotherapy discoveries supported by #CancerResearch (70 years and going strong) and other agencies to create a world #Immune2Cancer
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Check out this perspective on nutrient acquisition and metabolism control of macrophage responses in tumor, a collaboration between @XianZhang2016 @LiangliangJi & @MingLiLab @ImmunityCP #ASCO23
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Glad to share a perspective on nutrient acquisition and metabolism control of macrophage responses in tumor @ImmunityCP with @CancerResearch fellows @XianZhang2016 @LiangliangJi
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Glad to share a holistic immuno-oncology perspective through the lens of #TGFb @NatRevImmunol with implication for preclinical model choice for drug testing https://t.co/ZKegGVtyvq
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Online now: Tumor-associated macrophages expressing the transcription factor IRF8 promote T cell exhaustion in cancer
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New in @ImmunityCP: a team led by the @MingLiLab at MSK reports a unique function for tumor-associated macrophages (TAMs) in dampening tumor immunity — an immune regulation mechanism they're optimistic might be targeted with #immunotherapy in the future.
cell.com
Macrophages of distinct origin and function populate tumors. Nixon et al. examine how cancer impacts mononuclear phagocytic antigen-presenting cells and find that monocyte-derived tumor-associated...
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Tumor-associated macrophages present cancer cell antigen and drive cytotoxic T cell exhaustion. Check out our story from brilliant Briana Nixon, @dkuo @arihakimi and collaborators
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