Michael Dustin
@MichaelLDustin
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Immunology, Cell Biology, Microscopy, Golden Retrievers, Country Walks
Oxford, England
Joined April 2019
RT @KirOxford: We are delighted to announce that Professor Paul Kubes will deliver the Newton-Abraham Lecture 2025 on 19 May, 16:30-17:30.….
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Selective requirement of glycosphingolipid synthesis for natural kille.
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RT @labs_mann: Congratulations to Matthias Mann @labs_mann on election to the prestigious National Academy of Sciences! Your innovative pro….
nasonline.org
WASHINGTON — The National Academy of Sciences announced today the election of 120 members and 30 international members in recognition of their distinguished and continuing achievements in original...
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A weakly self reactive T cell receptor (magenta) can protect healthy tissue from a runaway CAR (green)! .See how in:. Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity: Cell
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Activation-induced thrombospondin-4 works with thrombospondin-1 to build cytotoxic supramolecular attack particles | PNAS
pnas.org
Cytotoxic attack particles released by CTLs and NK cells include diverse phospholipid membrane and glycoprotein encapsulated entities that contribu...
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Solution structure and synaptic analyses reveal determinants of bispecific T cell engager potency .When is flexibility not a good thing? When your a bispecific T cell engager! Latest update on TcE project @UniofOxford @Boehringer.
biorxiv.org
Bispecific T-cell engagers (TcEs) link T cell receptors to tumor-associated antigens on cancer cells, forming cytotoxic immunological synapses (IS). Close membrane-to-membrane contact (≤13 nm) has...
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Multi-omic characterisation of helper T cell extracellular vesicles that raise the alert!.A resource for extracellular vesicles from activated CD4 T cells that relay pro-inflammatory signals
biorxiv.org
CD4 T helper cells (TH cells) play a vital role in coordinating and amplifying the immune response to specific pathogens. They constitutively produce different kinds of extracellular vesicles (EVs),...
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Interesting paper that builds on earlier work with DNA-CARs, linking DNA based interactions to TCR!.Differential roles of kinetic on- and off-rates in T-cell receptor signal integration revealed with a modified Fab’-DNA ligand | PNAS
pnas.org
Antibody-derived T-cell receptor (TCR) agonists are commonly used to activate T cells. While antibodies can trigger TCRs regardless of clonotype, t...
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A novel method for characterizing cell-cell interactions at single-cell resolution reveals unique signatures in blood T cell-monocyte complexes during infection
biorxiv.org
Communication between immune cells through direct contact is a critical feature of immune responses. Here, we developed a novel high-throughput method to study the transcriptome and adaptive immune...
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JCI - Microbial mimics supersize the pathogenic self-response
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T-cells with extra batteries!⚡️⚡️⚡️.Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy: Cell
cell.com
Transfer of mitochondria via nanotubes from bone marrow stem cells to CD8+ T cells augments cellular metabolism, empowering engineered T cells and tumor-infiltrating lymphocytes to counteract...
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Mechanical force matters in early T cell activation | PNAS
pnas.org
Mechanical force has repeatedly been highlighted to be involved in T cell activation. However, the biological significance of mechanical force for ...
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Reaching last day of an amazing event including three new @royalsociety Medal recipients!.
Brilliant start to #LabToClinic! We heard about the beginnings and impact of biological therapies, as we celebrate 25 years of biologicals being approved for #RheumatoidArthritis. We look forward to some wonderful talks over the coming days. More info⬇️.
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RT @luglilab: Our latest paper "NaCl enhances CD8+ T cell effector functions in cancer immunotherapy" is now out @NatImmunol .
nature.com
Nature Immunology - Along with a back-to-back published paper from Zielisnki and co. in this issue of Nature Immunology, this paper shows that NaCl affects CD8+ T cell function by...
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Immuno-STATS create an immunological synapse to boost both the T cell receptor and IL-2 receptor signaling among the RIGHT T-cells!.
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Synaptic synergy of T cell receptor and interleukin 2 receptor in CD8+ T cells
biorxiv.org
Interleukin 2 (IL2) promotes T cell proliferation and differentiation, making it a central target in immunotherapies. T cells fine-tune their sensitivity to and consumption of IL2 by regulating...
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Excited that we got the cover on a special issue of Biophysical Journal on Biophysics of Immune Cell Signaling with @JesusaCapera @ndorms @KirOxford article on Dynamics and spatial organization of Kv1.3 at the immunological synapse.
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RT @MitoPsychoBio: The time to think and inquire are precious. Inquiring means to contemplate a problem without needing an immediate answe….
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Excited that this heroic study on nuclear positioning of PD-1 locus in primary T cells from acute and chronic viral infection models is out!.
Happy to share the publication of this article @CellReports @CellPressNews from our research group!! @nyugrossman @KirOxford @EmoryVaccineCtr @MichaelLDustin @rafiahmed_lab @EmoryMedicine @jane_skok @CatySacristan
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Chronic viral infection alters PD-1 locus subnuclear localization in cytotoxic CD8+ T cells: Cell Reports
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