MatthiasFellner
@MFellnerLab
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Understand protein structure-function relationships and use this knowledge to answer fundamental questions of chemistry/biochemistry at the University of Otago.
Joined April 2020
Just out: Covalent isothiocyanate inhibitors of macrophage migration inhibitory factor as potential colorectal cancer treatments. Great collaborative effort between @OtagoPharmacy @joel_tyndall , @OtagoBiochemist and @otago Chemistry https://t.co/6TbfopBpN7
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New @BiochemistryACS paper about one of my favorite enzymes ever - Structural, Spectroscopic, and Computational Insights of the Ethylene-Forming Enzyme. Collaboration between @MSU_BMB @michigantech and myself at @OtagoBiochemist
https://t.co/kLcDUw3Rwm
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Structures just released https://t.co/02mOEJW0zc
https://t.co/Psyt4YE0y0 determined in collaboration with @Stanford @mbogyo and my lab at @OtagoBiochemist - JACS paper on Probes for Specific Detection of Staph Infections https://t.co/tsUazuuCBr
@JeyunJo @TulsiUpadhyay5 +others
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Check out our latest covalent probes for imaging Staphylococcus aureus infections published @J_A_C_S. Great work from @JeyunJo and @TulsiUpadhyay5 and collaborators.
pubs.acs.org
Staphylococcus aureus (S. aureus) is a major human pathogen that is responsible for a wide range of systemic infections. Since its propensity to form biofilms in vivo poses formidable challenges for...
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Thrilled to share the news!! Thanks Matt @mbogyo, for giving this fantastic opportunity to work on this project. Enjoyed teaming up with @JeyunJo, @MFellnerLab and all our collaborators š Thanks @ec_woods, @NikkiPedowitz, @SijieWang5 for helping us with this project!!
Check out our latest covalent probes for imaging Staphylococcus aureus infections published @J_A_C_S. Great work from @JeyunJo and @TulsiUpadhyay5 and collaborators.
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Exciting news from our recent research with @TulsiUpadhyay5 on oxadiazolone-based probes targeting FphE, a S. areus specific serine hydrolase. This is a result of great collaboration with @MFellnerLab, the Valdez lab, Joanna Jaworek-Korjakowska, and the team at @mbogyo lab.
Looking for a new covalent electrophile for serine and cysteine nucleophiles? Check out this great work by ā¦@JeyunJoā© and ā¦@TulsiUpadhyay5ā© developing an oxadiazolone based probe for the S aureus serine hydrolase FphE.
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Looking for a new covalent electrophile for serine and cysteine nucleophiles? Check out this great work by ā¦@JeyunJoā© and ā¦@TulsiUpadhyay5ā© developing an oxadiazolone based probe for the S aureus serine hydrolase FphE.
biorxiv.org
Staphylococcus aureus is a major human pathogen responsible for a wide range of systemic infections. Since its propensity to form biofilms in vivo poses formidable challenges for both detection and...
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1. characterization of a highly conserved S. aureus serine hydrolase. https://t.co/uSY7x90bUP
@OtagoBiochemist (Annabel Walsh) OtagoChemistry (Sutherland, Tan) & international collaborators A. Bakker, @mariovdstelt, @NatMart_Chembio, @NadiaAftab18, S. Dela Ahator @ChristianSLentz
pubs.acs.org
The development of new treatment options for bacterial infections requires access to new targets for antibiotics and antivirulence strategies. Chemoproteomic approaches are powerful tools for...
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One week left to apply #postdoc #position in #biochemistry on #research into #peptide & #enzyme via #phage in ##infectiousdisease at #university @OtagoBiochemist in #NewZealand and #Shanghai #SIMM Details: https://t.co/yeexj27HK6
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We are looking for a Postdoctoral Fellow to create peptide tools for the treatment & diagnosis of infectious diseases at the University of Otago & Shanghai Institute of Materia Medica. Funded by New Zealand Maurice Wilkins Centre Starting September Details https://t.co/yeexj27HK6
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We are looking for an Assistant Research Fellow to create Staphylococcus aureus samples for metabolomics to identify the roles of serine hydrolases in biofilms ( https://t.co/YnrnngQ9T8) University of Otago, Dunedin, New Zealand. Starting in July Details:
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Bacterial biofilm therapeutics project wins Marsden Fund support https://t.co/sDEbeXB52S A project investigating new ways to fight deadly bacterial biofilms has won a Marden Fast-Start fellowship for its lead researcher, Otago biochemist Dr Matthias Fellner. Matthias is seekiā¦
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Otago researchers set to tackle health issues with Career Development Awards https://t.co/QeWBxPtBZY From a global health crisis to Aotearoaās health inequity ā University of Otago projects awarded Health Research Council funding will benefit those at home and around the worldā¦
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$3.8 million to Otago researchers in Career Development Awards https://t.co/yG7ZluWto7 The Health Research Council has awarded 19 Otago researchers almost $3.8 million in Career Development Awards. These awards help launch research careers through a wide range of masterās andā¦
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Taputapu kÄ! Dr Matthias Fellnerš§āš¬ @MFellnerLab @OtagoBiochemist @otago has been awarded a #MarsdenFund Fast-Start to study how #Staphylococcus aureus š¦ use biofilms in antibiotic š resistant bacteria #infection sš„. #staph #AntibioticResistance
https://t.co/klXgWR8K1T
royalsociety.org.nz
Dr Matthias Fellner of Te Whare WÄnanga o ÅtÄkou the University of Otago will develop new drugs targeting biofilms which play an important role in chronic antibiotic-resistant bacterial infections
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Really excited to have our paper describing mutations in histone H4 now out - a fantastic collaboration with @GijsvanHaaften and lots of families around the world. Now investigating the mechanism thanks to @MarsdenFund support!
New! Tessadori et al. demonstrate that de novo variants in histone H4 cause a neurodevelopmental disorder https://t.co/T8VnSoa0cs
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@GijsvanHaaften @MarsdenFund Thanks also to @MacePeter for helping with the structural interpretations of these mutations within the nucleosome!
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Newly discovered #Staphylococcus aureus serine hydrolase probe and drug targets https://t.co/95blTPPptY My latest review of ten S. aureus protein targets for probe & drug development. Looking forward to new advances @mbogyo @ChristianSLentz and myself @OtagoBiochemist.
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Excited to share my latest paper in #JournalofLifeSciences on #Cesium binding in #protein #crystals based on work between @MSU_NatSci and @OtagoBiochemist
https://t.co/vjdfFttu1V Consider #caesium in your #crystallography experiments to improve #diffraction or solve #phases.
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Altered structure and dynamics of pathogenic cytochrome c variants correlate with increased apoptotic activity https://t.co/CNcu5c3MZo Our latest work hot off the press from @OtagoBiochemist. Thanks @parakra, KD, @ItamarKass, @gnljameson, SMW & @Liz_Ledgerwood
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