Sijie Wang
@SijieWang5
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Los Angeles-West Lafayette-Palo Alto, Boilermaker, Postdoc @ Stanford
Stanford, CA
Joined February 2020
Thanks @DanNomura for highlighting our recent work!
Cool paper from Matt Bogyo’s lab: Identification of Covalent Cyclic Peptide Inhibitors Targeting Protein–Protein Interactions Using Phage Display | Journal of the American Chemical Society
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My privilege to collaborate with @WangUCSF @FrancoFaucher @matildebertolin, Heeyoung (Bartenschlager lab) and others!
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Macrocycles are known to block large and sometimes discontinuous PPI interface. We stick with this idea by covalency! We took this a step further by combining our covalent phage display platform and a binary/ternary screening workflow for identifying covalent PPI inhibitors.
Busy week for @SijieWang5! His second paper in two days is out describing the use of phage display to identify covalent inhibitors of protein/protein interactions. Great work and collaboration. https://t.co/rGXKnfSho2
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Busy week for @SijieWang5! His second paper in two days is out describing the use of phage display to identify covalent inhibitors of protein/protein interactions. Great work and collaboration. https://t.co/rGXKnfSho2
biorxiv.org
Peptide macrocycles are promising therapeutics for a variety of disease indications due to their overall metabolic stability and potential to make highly selective binding interactions with targets....
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A great collaboration between Bogyo lab and Genentech. I had a lot of fun learning mRNA display and warhead encoding! Big thanks to all collaborators involved in this project! @ec_woods @JeyunJo @BwTabbyGinger @NikkiPedowitz @TulsiUpadhyay5 @ChemBio_John
After a lot of work by @SijieWang5 to finish the project I started while at Genentech on sabbatical last year, we have finally posted the results to bioRxiv.
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After a lot of work by @SijieWang5 to finish the project I started while at Genentech on sabbatical last year, we have finally posted the results to bioRxiv.
biorxiv.org
Staphylococcus aureus ( S. aureus ) is an opportunistic human pathogen that causes over one million deaths around the world each year. We recently identified a family of serine hydrolases termed...
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Looking for a new covalent electrophile for serine and cysteine nucleophiles? Check out this great work by @JeyunJo and @TulsiUpadhyay5 developing an oxadiazolone based probe for the S aureus serine hydrolase FphE.
biorxiv.org
Staphylococcus aureus is a major human pathogen responsible for a wide range of systemic infections. Since its propensity to form biofilms in vivo poses formidable challenges for both detection and...
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A huge congrats to my graduate student Andy Heindel for publishing his work on developing PACCE for global quantification of protein-RNA binding activity in live cells. We thank our collaborators Markus Hafner @NIH_NIAMS & Thurl Harris @uvapharmacology.
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I'm delighted to release the first half of my new open-access online textbook in human population genetics: https://t.co/GHMPCTv6BL
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Check out our latest work targeting the malaria proteasome. Another outstanding collaboration with @fidocklab. Congrats to @ChemBio_John and the other authors!
pubs.acs.org
The Plasmodium proteasome is a promising antimalarial drug target due to its essential role in all parasite lifecycle stages. Furthermore, proteasome inhibitors have synergistic effects when combined...
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Awesome paper from Jack Taunton’s lab @UCSF on direct mapping of ligandable tyrosines and lysines in cells with chiral sulfonyl fluoride probes using chemoproteomics!
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Check it out! @kellerlauraj’s masterpiece of her thesis work is finally in print. Great work and just in time for her graduation.
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Did you register yet to ABPP 2023??? 17-19/7/2023 Please RT! 🧪💥 https://t.co/I4F5KJma0F
#ABPP #Proteomics #Covalent #BestMeetingEver
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Congrats to BC and YB on their recent paper on DEL selection of biased GPCR agonists! Big thanks to terrific collaborators Amal and Tao! #DELagonists #CIDselection #JACSau
pubs.acs.org
G protein-coupled receptors (GPCRs) are the largest superfamily of human membrane target proteins for approved drugs. GPCR ligands can have a complex array of pharmacological activities. Among these...
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Paper just published. That was fast! Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows - Faucher - Israel Journal of Chemistry - Wiley Online Library
onlinelibrary.wiley.com
Macrocyclic peptides are attractive for chemoproteomic applications due to their modular synthesis and potential for high target selectivity. We describe a solid phase synthesis method for the...
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Our latest paper is out at bioRxiv. Great work from @FrancoFaucher and collaboration with Alex Adibekian.
biorxiv.org
Macrocyclic peptides are attractive for chemoproteomic applications due to their modular synthesis and potential for high target selectivity. We describe a solid phase synthesis method for the...
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Engineered PROTAC-CID Systems for Mammalian Inducible Gene Regulation
pubs.acs.org
Gene regulation via chemically induced dimerization (CID) is useful for biomedical research. However, the number, type, versatility, and in vivo applications of CID tools remain limited. Here, we...
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An effective tool developed by Genentech to evaluate the IVT efficiency of NCAA in peptidic library design and synthesis... Titled as "Evaluating Translational Efficiency of Noncanonical Amino Acids to Inform the Design of Druglike Peptide Libraries" https://t.co/VW4SSHMJv3
pubs.acs.org
Advances in genetic code reprogramming have allowed the site-specific incorporation of noncanonical functionalities into polypeptides and proteins, providing access to wide swaths of chemical space...
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New Receptor “Decoy” Drug Neutralizes COVID-19 Virus and Its Variants ://ms.spr.ly/6047eW78R
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