Mempel Lab
@MempelThorsten
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Exploring the friendship between T cells and dendritic cells since 2007 at Massachusetts General Hospital and Harvard Medical School. Opinions are Thorsten’s.
Boston, Massachusetts
Joined February 2021
Yet another way chemokines do their important work, as reported by the Stein lab.
Lymphoid stromal chemokines act as built-in "disruptors" of T cell-DC interactions for long-term preservation of T effector functionality @LukasAltenburg2 @Steinlab_unifr.
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Definitely one of the greatest perks of being a PI is when your former trainee starts publishing his own cool papers. Check out Francesco Marangoni's paper in Cancer Cell describing how a-PD-1 checkpoint blockade increases intratumoral Treg cell activity:
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RT @Immuno_Mike: Study host-microbe interactions in sunny San Diego, CA! Fully-funded postdoc opportunity in the Constantinides Lab @MGClab….
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Join us at the 2024 @GordonConf on chemotactic cytokines, June 1-7. Explore cutting-edge, unpublished research, and enjoy interactive discussions among scientific colleagues. RT to spread the word. Apply now! #immunology #neurobiology #cancerbiology
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A nice intravital microscopy study illustrating how activation of Leishmania-specific Treg cells can promote reactivation of latent parasite lesions.
Happy to share our most recent work led by the brilliant @RomaniyaZ in close collaboration with @drleish out now at @NatureComms!.We examined the concept of immunodominant regulatory T cell responses during L. major skin infection in vivo using MP-IVM 1/n.
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Happy to share a link to our review of chemokines in cancer in @NatureRevCancer. We explore how chemokine programs that evolved for inflammation, tissue repair, antimicrobial defense etc shape tumor microenvironments. Tx to @LukasAltenburg2 and Julia Lill.
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RT @ImmunityCP: Dendritic cells as shepherds of T cell immunity in cancer: Pittet, Di Pilato, Garris, & Mempel review the current knowledge….
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I could not agree more. It's a mystery why it hasn't happened yet.
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Credit goes to @csgarrix for the nice shepherding metaphor (or is it a simile 🤔?) in the title. I ll always picture T cells as little sheep from now on. .
Happy to share a link to our recent review of dendritic cells in cancer, written together with the great @MempelThorsten @csgarrix and @DiPilatoMauro. Here is a link giving full access to the paper:
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Thanks so much for hosting me, Thomas. It was my great fortune to have you in the lab, and now seeing you succeed with your own operation is even greater reward.
Thank you to my postdoc mentor @MempelThorsten for visiting us @UM_Immu @UM_RadyFHS. Your mentorship really guided my career in the right direction and I am who I am now because of your brilliant scientific mind. Thank you and see you again soon!
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An impressive paper describing a remarkable advance in imaging technology and its application for intravital imaging of immune cells dynamics. A must read for any IVM aficionado.
In collaboration with Prof. Dai Qionghai & Wu Jiamin's group @Tsinghua_Uni, reporting in @CellCellPress the new 2-photon synthetic aperture microscopy that enables us to watch the entire process of germinal center formation.
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RT @DiPilatoMauro: I am very happy to share our translational studies on Treg fragility. Mepazine works in patient-derived organotypic tumo….
meridian.allenpress.com
ABSTRACTIntroduction. Regulatory T cells (Tregs) play a critical role in the maintenance of immune homeostasis but also protect tumors from immune-mediated growth control or rejection and pose a...
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Here we reviewed MALT1 protease inhibitors as newly emerging therapeutics not only for lymphoma, but also for solid cancer, based both on their direct effects on cancer cells as well as the conversion of tumor-infiltrating Treg cells into pro-inflammatory effectors.
New #JITC review: Combining precision oncology and immunotherapy by targeting the MALT1 protease @MempelThorsten
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Couldn't agree more. And then there is the famous clam "chowda".
Are you a physician scientist? Are you interested in joining an amazing team of physicians and scientists (like @MempelThorsten @WayneShreffler @Rahimi_lab and so many more)? . Of course you are! . The CIID at MGH is hiring for a tenure track position! (1/3)
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RT @OdedRechavi: If Darwin went on his voyage of the Beagle today his research would've ended with a t-SNE of the bird specimens that he co….
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What a phantastic idea: Using -omics computational tools to analyze intravital microscopy data on immune cell migration. Congrats, Andres, Miguel, and Georgiana, and thanks for allowing us become a (very) small part of this.
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Distinct roles of CXCR3 ligands CXCL9 and 10 during chronic viral infection. CXCL10 lures CTL into the red pulp to hasten their terminal differentiation, accelerating depletion of the TCF-1+ stemlike memory pool and limiting viral control. Congrats, Ola.
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