McManus Lab @CMU Profile
McManus Lab @CMU

@McManusRNALab

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We study mechanisms and evolution of gene expression

Pittsburgh, PA
Joined April 2021
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@McManusRNALab
McManus Lab @CMU
10 months
RT @GeneticsGSA: Exciting news for our community 🎉 #NobelPrize. Victor Ambros and Gary Ruvkun have been awarded the 2024 Nobel Prize in Phy….
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@McManusRNALab
McManus Lab @CMU
11 months
RT @NatureBiotech: A new nanopore sequencing method can translocate long proteins, enabling detection of single amino acid substitutions an….
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nature.com
Nature - A technique for threading long protein strands through a nanopore by electrophoresis and back using a protein unfoldase motor, ClpX, enables single protein molecules to be analyzed...
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@McManusRNALab
McManus Lab @CMU
11 months
RT @GreenLabJHMI: We’ve captured the splitting image of Slh1: our work on an enzyme that splits collided ribosomes in E. coli is out on bio….
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biorxiv.org
Although many antibiotics inhibit bacterial ribosomes, loss of known factors that rescue stalled ribosomes does not lead to robust antibiotic sensitivity in E. coli , suggesting the existence of...
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@McManusRNALab
McManus Lab @CMU
11 months
RT @maxewilkinson: My favourite discovery ever has just come online. Can I please tell you about some seriously wacky molecular biology? Th….
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@McManusRNALab
McManus Lab @CMU
11 months
RT @KalsotraLab: What a fascinating discovery.
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@McManusRNALab
McManus Lab @CMU
11 months
RT @Jayquerido: Our new paper is finally out!.We discovered that the human tumor suppressor protein Pdcd4 binds to the #mRNA entry channel….
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@McManusRNALab
McManus Lab @CMU
11 months
RT @CmuScience: The Department of Biological Sciences is bringing quantitative biology to the forefront. https://t.….
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@McManusRNALab
McManus Lab @CMU
11 months
RT @KoliaRoiuk: Last week my main project was published at @NatureComms, so there is a thread about our findings: .
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@McManusRNALab
McManus Lab @CMU
11 months
RT @scientistmomEB: Cannot say enough positive things about publishing this study in #GENETICS - reviewers gave really important feedback a….
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@McManusRNALab
McManus Lab @CMU
1 year
RT @biorxiv_biophys: eIF1 and eIF5 dynamically control translation start site fidelity #biorxiv_biophys.
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@McManusRNALab
McManus Lab @CMU
1 year
Delighted to share our recent manuscript on the roles of P-body factors in Candida albicans filamentation and stress response . Fantastic collaboration with Aaron Mitchell (UGA) and Fred Lanni (CMU), led by an amazing graduate student (@MTosiano)!.
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biorxiv.org
Hyphal growth is strongly associated with virulence in the human fungal pathogen Candida albicans . While hyphal transcriptional networks have been the subject of intense study, relatively little is...
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@McManusRNALab
McManus Lab @CMU
1 year
Check out our most recent manuscript Christina Akirtava (@bio2data) and Gemma May (@gemmaemay) tested > ten thousand natural yeast transcript leaders (5' UTRs) and determined the relative roles of RNA sequence motifs and structures. Nice work!.
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biorxiv.org
Protein synthesis is a vital process that is highly regulated at the initiation step of translation. Eukaryotic 5’ transcript leaders (TLs) contain a variety of cis -regulatory features that influe...
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@McManusRNALab
McManus Lab @CMU
1 year
RT @thesilvalab: And then this email my box today!! I'm extremely happy and honored to announce that I've been awarded TENURE and promoted….
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@McManusRNALab
McManus Lab @CMU
2 years
RT @yeo_lab: However, amidst the myriad of predicted RBPs, it's unclear which ones affect exon inclusion directly. Our latest research @Nat….
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link.springer.com
Nature Biotechnology - Alternative splicing is controlled with engineered fusion splicing factors.
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@McManusRNALab
McManus Lab @CMU
2 years
RT @NatureBiotech: Large-scale evaluation of the ability of RNA-binding proteins to activate exon inclusion https:/….
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@McManusRNALab
McManus Lab @CMU
2 years
RT @GreenLabJHMI: Check out our new preprint in collaboration with @jingdongcheng lab about how LARP1 senses the abundance of non-translati….
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