Have you ever wondered how the same pathway can elicit different responses in distinct contexts? Check out the second part of my PhD work, now available @Dev_journal.Read the full story here: .Or read the tweetorial below (1/7).

Great work by @mproksik and @nazsalehin ! It works beautifully on the phone as well 😎 Congratulations!.

Join millions who have switched to Grok.

Very happy to see our story now in the final form. And (perhaps) more importantly, we have contributed with a tree to The Forest of Biologists! 🌲🌳🌿

RT @SEBiolDev: Spooky 👻 🧑🏼‍🔬👩‍🔬🎃

Finally, although this paper only features @josh_brickman and myself, it could not have been possible without the amazing support of everyone at @Lab_Brickman ! (7/7) #Signalling #Transcription #FGF #ERK #Chromatin.

Finally, ERK represses pluripotent transcription in naïve cells and activates it in primed ones (even naïve pluripotency genes in primed cells) suggesting some sort of feedback mechanism accounts for the difference between naïve and primed pluripotent gene expression (6/7)

We also found that the chromatin accessibility landscape influences the transcriptional response: induction in naïve pluripotency involves chromatin remodelling, while in primed pluripotency it exploits existing accessible regions (5/7)

We used it to investigate what controls specificity of signalling responses in pluripotent cell types: naïve, rosette and primed. While we observed significant overlap in positive regulation at both chromatin and transcriptional level, repression was entirely cell specific (4/7)

Activation of ERK with this new model was more efficient in driving PrE from the ICM than the same length of FGF4 treatment (3/7)

We developed a new model that allows to induce ERK phosphorylation in vitro and in vivo, in your tissue and time of choice, a variation on @Lab_Brickman previous intrinsic model of ERK induction in ESCs ( (2/7)

RT @SchuhLab: Each month an #egg is ovulated from the #ovary, starting the journey of reproduction. But how does ovulation occur?🥚. Our lat….

RT @BernaSozen_: Our latest out today @Nature!.We revisit a century-old theory and show that metabolic gradients work hand-in-hand with gen….

RT @boroviak_lab: Curious embryo fact 1/25. The embryo is the only machine that needs to function while it is being built. This is made po….

RT @adeflamingh: Paper out today! We used tiny hair fragments from the teeth of the historic #TsavoLions to identify their prey 🦓🦒🦁 @Curren….

RT @UCDflowerpower: GWAS for Nobel prize laureates.

RT @CurrentBiology: 👇.🐟🦵🦵🦵.

RT @metzisv: ICYMI: we are hiring! Come and join us ⁦@MRC_LMS⁩ for a #postdoc . #regulatorylogic #devbio #stemcellmodels in an excellent en….

A wild Xenopus embryo appeared watching The Substance! It's in the trailer but best enjoyed in a big cinema screen #DevBio #CorruptedbyScience #TheSubstance

Did you know that some plants imitate the shape of their plastic neighbours? This year's Ig Nobel winners are here! As usual, setting the standards for the kind of researcher I aspire to become #IgNobelPrize

I'm very grateful that I was able to contribute to this fantastic story! Congratulations @MLAgerholm_ !! #PowerToPrE.