Mark Dodding
@MarkDodding
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Professor of Molecular Cell Biology at University of Bristol
Bristol, England
Joined June 2010
We have new preprint on biorxiv on kinesin-1 inhibition and activation. Collaborative effort across @BristolBiochem @BristolChem with @WoolfsonLab and Christiane Schaffitzel Lab with @ProteinMotion at U Exeter 1/2 https://t.co/oYRJiCgtWf
biorxiv.org
Kinesin-1 is a dynamic heterotetrameric assembly of two heavy and two light chains (KHC and KLC) that mediates microtubule-based intracellular transport of many different cargoes. The complex adopts...
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and a postdoc position working between our lab and @WoolfsonLab design proteins and peptides to augment kinesin-1 activity 2/2 https://t.co/0WWgylZMbS
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We have a new 4-year postdoctoral position available working between our lab an the @WoolfsonLab @BristolBiochem @BristolChem applying protein design approaches to control intracellular transport. More info on flyer. Get in touch!
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Our paper explaining why two motor proteins that walk in opposite direction depend on each other is finally out. Great collaboration with @Carter_Lab, initiated by @zwetza, beautiful structural biology by @fe_aali. A thread 🧵 (1/9)
nature.com
Nature Structural & Molecular Biology - Here the authors show that codependence of dynein and kinesin KIF1C occurs through binding of the FTS–HOOK3–FHIP1B cargo adapter. Binding of...
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We have three PhD projects with motor-cytoskeleton theme though collaborations with three new(ish) PIs at @BristolBiochem supported by @SWBio_DTP with Berni Carroll (lysosome transport), @fe_aali (endocytosis) and @jessica_a_cross (protein design) see
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Applications are now open for the Lister Prize 2025. Please apply by midnight (GMT) on Monday 23 September 2024. Start your application here:
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A great collaboration with @Daniellempaul @HersIngeborg @PaulVerkade @alastair_poole labs with great support from @GW4CryoEM, funded by @wellcometrust @ListerInstitute @BBSRC and @TheBHF
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Our latest paper on actin within platelet microtubules led by @ChisatoTsuji is now in print. https://t.co/3fwNOoo9Aa Where else might those little turduckens 🦃🦆 be hiding? @BristolBiochem @UoBrisPPN
nature.com
Nature Communications - Using focused ion beam milling and cryoelectron tomography, Tsuji et al. found actin filaments, with both cofilin-bound and canonical morphologies, within the lumen of human...
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We're thrilled to announce 2024's brand new #ListerFellows! @DavidsnDeathLab
@bcells_rosser
@nickywhiffin
@AlexBoRNA
@theRAD_lab
@SarahDimeloeLab welcome to the fold 🥳📷 🎈 https://t.co/0YL5agv6er
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Great to see our work on manipulating kinesin-1 activity using protein design led by @jessica_a_cross in print. In collaboration with @WoolfsonLab. @BristolBiochem @BristolChem @BrisBioDesign
https://t.co/wJXwDxdCxB
nature.com
Nature Chemical Biology - The kinesin-1 motor protein accesses open active and closed autoinhibited states. These states are regulated by a flexible elbow within a complex coiled-coil architecture....
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Really interesting work from McKenney lab on actin-microtubule crosstalk mediated by kinesin-1 and Nesprin-2G
biorxiv.org
Nesprins are integral membrane proteins that physically couple the nucleus and cytoskeleton. Nesprin-2 Giant (N2G) stands out for its extensive cytoplasmic domain, which contains tandem N-terminal...
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We have two new faculty/group leader positions available at @BristolBiochem at Lecturer/Senior lecturer /Associate Professor levels. Links below. One with a broadly defined 'omics' remit and the other anything Biochemistry, Biophysics, Molecular Cell Biology or Syn Bio. Join us!
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Alexander Fellows, Andrew Carter et al @MRC_LMB show that individual #dynein motors can move the entire axon length during retrograde transport. In the anterograde direction, dynein & dynactin are transported separately, keeping them apart until required. https://t.co/ytonqThNFa
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If you are interested in joining my group to study how microtubule motors select their cargos (or vice versa) then please see the two adverts below. One is based on neuronal cell biology, the other on reconstitution and cryoEM. https://t.co/TnOfhXFZ07
https://t.co/JfC8Jk5vcD
nature.com
Postdoctoral Scientist Salary £39,375 per annum MRC Laboratory of Molecular Biology, Cambridge, UK An opportunity is available for a postdoctoral r...
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This is great news to the see the work of our dear friend and colleague @David_S_Bristol recognised by the @RoyalMicroSoc Huge congratulations ! 🥳🥳🥳
We are delighted to announce Professor David Stephens @David_S_Bristol as the latest recipient of the RMS Scientific Achievement Award! Many congratulations! 👏👏👏🔬🔬🔬 Read more: https://t.co/DXl8TJr8wQ
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The last of my PhD work is finally out in @NatureComms 🥳 after a huge team effort over several years! Thanks and congrats to all fantastic co-authors @emilyjglover1 @MitoPereira_GC @MarkDodding @IanofBristol (who led the show!), Alina Witt, Wolfgang Hübner, and Jeremy Henley!
Bravo! @hopeneeds –final instalment of her trilogy of #mitochondria papers @BristolBiochem Massive effort also with @emilyjglover1 (check her pic!) @MitoPereira_GC Alina Witt, Wolfgang Hübner, @MarkDodding & Jeremy Henley Funded by @wellcometrust & @BBSRC
https://t.co/EdFQ7Tp1zb
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Bravo! @hopeneeds –final instalment of her trilogy of #mitochondria papers @BristolBiochem Massive effort also with @emilyjglover1 (check her pic!) @MitoPereira_GC Alina Witt, Wolfgang Hübner, @MarkDodding & Jeremy Henley Funded by @wellcometrust & @BBSRC
https://t.co/EdFQ7Tp1zb
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We're recruiting! Come and join us! @BristolBiochem is looking to appoint a Senior Lecturer/Associate Professor in Molecular Cell Biology. https://t.co/0ZHu9tUv5r
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