Maresca Lab
@MarescaLab
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RT @biorxiv_cellbio: Proximity-based activation of AURORA A by MPS1 potentiates error correction #biorxiv_cellbio.
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Meiosis-specific functions of kinetochore protein SPC105R required for chromosome segregation in Drosophila oocytes
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RT @ArmrYshr: Magnetic Isolation and Concentration (MagIC)-cryo-EM is a new method to enable direct structural analysis of targets captured….
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RT @RusanLab: I am hiring in 2024. Contact me if you'd like to learn about my lab and the NIH
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RT @JCellBiol: Image shows characterization of cytosolic Spc105 oligomers. McGory et al. @MarescaLab @UMassAmherst uncover a linkage betwee….
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RT @JCellBiol: Multimerization of a disordered #kinetochore protein promotes accurate chromosome segregation by localizing a core #dynein m….
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RT @JCellBiol: McGory et al @MarescaLab @UMassAmherst reveal that multimerization of the disordered #kinetochore protein Spc105 helps recru….
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Check out the new @marescalab preprint (with @viktzv and Pat Wadsworth). Look at that dynein go! .
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RT @Jor_Ferreir: Very happy and proud to share the work PhD student Joana Lima @i3S_UPorto “A nuclear signal in prophase determines centros….
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Check out our new preprint: An intrinsically disordered kinetochore protein coordinates mechanical regulation of chromosome segregation by dynein
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RT @CNS_UMass: Congrats to #UMass #Biology Assoc. Prof. & Dir. of the Molecular & Cellular Biology Program Tom Maresca @MarescaLab for bein….
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The Ndc80-Cdt1-Ska1 complex constitute a minimal processive kinetochore-microtubule coupling unit
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Spindle assembly in Xenopus egg extracts! Videos were taken while working late into the night at @MBLScience with Aaron Groen and @GatlinLab. The montage is from our (@viktzv) recent retrospective in @MBoCjournal on a seminal paper by @rebeccaheald.
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A celebration of the 25th anniversary of chromatin-mediated spindle assembly | Molecular Biology of the Cell
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Wish we could think seriously about the authors suggestion of an A/A-/Pass/Fail model, which is effectively the med school grading scheme.
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Favorite line from the article:.“Orville Wright died of a heart attack in January 1948. He had seen plane speeds go from 6.8 miles per hour on his first flight to 662 mph in 1947, when Air Force Capt. Chuck Yeager broke the sound barrier.”.
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Never knew Orville Wright had to fight his whole life (on behalf of he and his brother) for the Smithsonian to recognize they invented the airplane.
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And here's another movie from our @MBoCjournal paper. This time the optogenetic oligomerization was triggered in interphase cells.
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Punchline: optogentically oligomerized KNL1 recruits PP1 to microtubules in mitosis. KNL1 oligomers can bind microtubules and PP1 simultaneously. The Cry2 oligomerization tag - developed in the Schaffer lab @UCBerkeley and used in @brangwynnelab OptoDroplet assay - is powerful!.
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