New collaborative work:.ATTR amyloidosis is a degenerative disease characterized by TTR fibril deposition in organs like the heart, kidneys, liver, and skin. ATTR amyloidosis causes peripheral polyneuropathy, cardiomyopathy and dysfunction of organs.

RT @MartinPacesa: Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an am….

RT @jankosinski: ⏰ URGENT! ⏰ Into structural modeling, design, integration with experiments, evolution, or platforms? Join our conference,….

RT @BrigitteGalliot: #ISRB2025 I am deeply honored and delighted to have received the Distinguished Achievement Award from the Internationa….

RT @mimi1inh: Our #CryoET story on how a top antimalarial drug candidate perturbs the native malarial translation machinery is out @NatureS….

RT @unige_en: 🎓 UNIGE confirms its excellence! The University of Geneva has once again ranked 58ᵗʰ worldwide in the 2025 Shanghai Ranking.🌍….

RT @Twinsandmeblog: Being left-handed is more than a trait. It’s a constant lesson in resilience. #lefthanded #lefthandersday #lefthander….

RT @Mavs_FFL: This is the deepest NBA roster 💯 . Two starting lineups in one 🤯. #MFFL

RT @biorxiv_biochem: Structure of ATTRv-F64S fibrils isolated from skin tissue of a living patient #biorxiv_biochem.

We hope that you will enjoy reading this work and thank all authors for their contributions in all labs and of course our funding bodies for their continuous and invaluable support!.

To the best of our knowledge, this is the first amyloid fibril structure that has been determined from skin tissue of a living patient. Therefore, this work may guide the development ofspecific therapeutic strategies for ATTR amyloidosis, paving the way towards personalised care.

Importantly, our work demonstrates that a minimal amount of skin tissue (less than ten milligrams) enables the determination of a high-resolution structure (2.8 Å), which show structural conservation across different tissues and ATTR variants.

We show that the mutant form of transthyretin (TTR) is more likely to be incorporated into amyloid fibrils, and we identify novel post-translational modifications of ATTR fibrils.

In our study, we extracted pathogenic ATTR amyloid fibrils from the skin of a living patient carrying.a rare genetic TTR mutation (F64S), and characterised the fibrils using immuno-histochemistry, mass.spectrometry and cryo-EM.

RT @StanislauY: Happy to share our latest work on the structure and assembly of holocentric kinetochores! Huge thanks to Ines for a very fr….

RT @Swisscrystallog: Interested in the latest developments in materials discovery and structural science? ⚛️🔬💎🇨🇭 Submit your abstract and….

@FedEx @FedExHelp @FedExEurope The entire Friday the status was "delivered"! And a delivery notification was signed!.

@FedExHelp @FedExEurope @FedEx . What is going on? How can a package that is worth several thousands CHF be delivered with signature and then not, with no support from the hotline!.

A precious sample was sent with @FedEx @FedExHelp @FedExEurope from Geneva to Bonn. It was also indicated in the track sample that it was delivered in Bonn - with signature! And now after the "delivery" it is back on its way to Stuttgart. Sample that needs cooling with dry ice!

RT @NobelPrize: Today we remember one of the world's greatest scientists: Marie Skłodowska Curie. Curie dedicated her life to science. She….