Molecular Biophysics Unit, IISc
@MBU_IISc
Followers
2K
Following
74
Media
16
Statuses
166
Molecular Biophysics Unit (MBU) is a part of IISc that pursues cutting edge research in the areas of molecular biophysics and structural biology
Bengaluru, India
Joined July 2020
API & Biosimilar QC/R&D experts: Hands-on NMR Data Acquisition Workshop. Industry participants only. Strictly 10 seats. Investment: ₹1.5L + GST Apply now! https://t.co/Azrjl3DC4L
#NMRSpectroscopy #Pharma #biotech #IISc #APIManufacturing #Biosimilars #QC #RND
0
5
8
The abstract submission is extended till 24th April. Register and attend the exciting symposium!
We are organizing a 2-day "AI in Biophysics" symposium from 28-29 April. We bring together leading experts to facilitate interdisciplinary and lively discussions. Website: https://t.co/o5TMSAq9HQ Poster abstract deadline: April 18 Registration deadline: April 24
0
3
15
We are organizing a 2-day "AI in Biophysics" symposium from 28-29 April. We bring together leading experts to facilitate interdisciplinary and lively discussions. Website: https://t.co/o5TMSAq9HQ Poster abstract deadline: April 18 Registration deadline: April 24
1
23
57
The last date for submitting online applications for Research programmes for the Academic Year 2025-26 has been extended till *06 April 2025* https://t.co/OuU3dPQquf
0
2
4
Flexibility of flanking DNA is a key determinant of transcription factor affinity for the core motif by Debostuti Ghoshdastidar and Manju Bansal at @MBU_IISc
https://t.co/kHpExa4zQ0
@BiophysJ highlight — An official journal of @BiophysicalSoc
1
10
34
Check out the special issue of "Proteins: Structure, Function, and Bioinformatics Vol 93 (1): Jan 2025" commemorating GN Ramachandran Centenary @MBU_IISc. Link:
onlinelibrary.wiley.com
PROTEINS: Structure, Function, and Bioinformatics is an international protein science journal publishing experimental and analytic research in all areas of the field.
0
4
18
Out in Eur. Phys. J. Spec. Top., https://t.co/U6aTufu1Yl. We use our replica exchange with hybrid tempering (REHT) method to extract the Boltzmaan's weighted membrane-bound conformations of peripheral proteins. All work by grad student @mouli_njr, a Physican turned Biophysicist.
4
3
38
Published version of the preprint now available! The link to the preprint thread is below. Congratulations Sanjna @2point0Sam!! Link: https://t.co/w92YLdn7it
Preprint from our laboratory with work by Sanjna Kumari @2point0Sam demonstrates ion-channel degeneracy in a large morphologically realistic model population constrained by electrophysiological measurements from our lab in rat hippocampal granule cells (1/2)
1
5
30
Measuring Hydroxyl Exchange Rates in Glycans Using a Synergistic Combination of Saturation Transfer and Relaxation Dispersion NMR | Journal of the American Chemical Society @MBU_IISc #HydroxylExchange #Glycans #NMR @nmr900
pubs.acs.org
Molecular recognition events mediated by glycans play pivotal roles in controlling the fate of diverse biological processes such as cellular communication and the immune response. The affinity of...
0
9
23
We are excited to start the new year by sharing the latest paper from our lab @MBU_IISC, @iiscbangalore in @NAR_Open. Here, we report that the RTEL1 helicase interacts directly and functionally with the replication protein A (RPA). (1/5) @NIRANJANSAARC
https://t.co/H4pKvHKoah
academic.oup.com
Abstract. The regulator of telomere elongation helicase 1 (RTEL1) plays roles in telomere DNA maintenance, DNA repair, and genome stability by dismantling
31
21
144
Our recent work "The alteration of structural network upon transient association between proteins studied using graph theory" is out now in Protein: Structure Function and Bioinformatics @WileyBiomedical
https://t.co/ae7z9SSWeZ
@tandon_himani @caps_ncbs @MBU_IISc @iiscbangalore
onlinelibrary.wiley.com
Proteins such as enzymes perform their function by predominant non-covalent bond interactions between transiently interacting units. There is an impact on the overall structural topology of the...
10
3
24
Our work on the "Comparison of structural networks across homologous proteins" is out in PROTEINS: Structure, Function, and Bioinformatics | Wiley Online Journal @WileyBiomedical
https://t.co/bDCJasBKot
@MBU_IISc
onlinelibrary.wiley.com
Protein sequence determines its structure and function. The indirect relationship between protein function and structure lies deep-rooted in the structural topology that has evolved into performing...
4
4
14
#glycotime Out now in GLYCOBIOLOGY! Very chuffed to see this out as it's our first Glycan work !!! https://t.co/u1Tr5IeOlq Thanks to @RamrayB @hurryram @PenmatsaLab for discussions and insights! Also, thanks to @AnneImberty & @GlycobiologyUK for the smooth editorial process.
academic.oup.com
Abstract. The unique viviparous Pacific Beetle cockroaches provide nutrition to their embryo by secreting milk proteins Lili-Mip, a lipid-binding glycoprot
#glycotime The availability of physiologically unaltered Lili-Mip structure (in vivo crystals solved by @hurryram group) made it a very attractive model system to investigate the role of glycans on protein structure, dynamics, and function using MD sims. https://t.co/Mdvi4cROG0
4
6
39
https://t.co/zAtR1e8Oe6 Out now in @jbiolchem. Had a wonderful time working with @ShovamayeeMaha and @Sangeethayoga, who did all the heavy lifting !! Would like to acknowledge @India_Alliance, NSM (HPC grant @IndiaDST) @SankhyaSutraLab @DBTIndia @iiscbangalore @MBU_IISc
jbc.org
Fused in sarcoma (FUS) is an abundant RNA-binding protein, which drives phase separation of cellular condensates and plays multiple roles in RNA regulation. The RNA-binding ability of FUS protein is...
In our recent work, we provide high-resolution structural insights into the RNA-FUS binding. @Sangeethayoga and I are having a blast collaborating with FUS Zen master @ShovamayeeMaha @RNALab_Maharana :-) (Preprints link) https://t.co/JHGusNhwmb Salient findings in thread below
11
12
86
We are organizing our annual symposium, "NuBS23," tomorrow from 9 AM onwards at the Faculty Hall, IISc Main Building. Please join us to learn about our latest works and hear from our plenary speakers, @gsahu_iisc and @AshhadSufyan.
0
9
34
Very happy to share our recent study on characterization and comparison of permanent and transient intra-protein inter-domain interactions. https://t.co/pCVfJWttMe
onlinelibrary.wiley.com
Protein domains are structural, functional, and evolutionary units. These domains bring out the diversity of functionality by means of interactions with other co-existing domains and provide stabil...
7
7
23
Finally our research on thioamide modification and its implications in membrane permeability and bioavailability of cyclic peptides is out! Congratulations to the entire team! https://t.co/Il88SVrK4J
@hiteshvrm @b_khatrii @NishantRaj33828 @SohiniBioPharma @MBU_IISc
28
10
127
Its a pleasure to announce the publication of our latest work on the cryoEM structure of QacA resolved using Indian camelid antibodies in @embojournal . Fantastic effort by @PujaMajumder91 @shah_med @Pragyaahuja_6 and @Athreya_Arunabh. https://t.co/pB86yjM1n2
link.springer.com
The EMBO Journal - Efflux of antibacterial compounds is a major mechanism for developing antimicrobial resistance. In the Gram‐positive pathogen Staphylococcus aureus, QacA, a 14...
52
21
209
Excited to announce the publication of our study on the architecture of the ratGAT1 in the cytosol-facing, GABA bound state @NatureSMB. Brilliant effort @SmrutiR60158682 and well supported by @DeepthiJoseph @ArchishmanDakua @AthreyaArunabh
https://t.co/xfC2VNjj7b
95
31
300
Very happy to share our study uncovering the mechanism of DNA binding by an IDP! The disordered domain of CytR binds DNA through a fully folded minor conformation. @AthiNaganathan @BODHISATWANANDI @MBU_IISc
science.org
The intrinsically disordered cytidine repressor binds DNA via a folding-before-binding conformational selection mechanism.
20
25
75