Meng Lu
@LuMeng2020
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biophysicist at the Peking University, Beijing; love art, science and consciousness
Beijing, China
Joined January 2020
excited to share our new study: multi-module recording of neuronal network's structural dynamics! two fundamental methods to record neuronal activity: imaging and ephys. Here we combine them together to simultaneously record and activity and structure. Great work from MNG!
🧵: 1/ How can graphene, super-resolution microscopy, and machine learning help us to understand the brain? 🧠Find out more in our new paper in Advanced Science! 👇 https://t.co/ZikzVDFguX
@AdvPortfolio @cebcambridge @GrapheneUCam @GrapheneEU @Cambridge_Uni #Grapheneweek2024
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Thrilled to share our new study! Sea cucumber extract can protect skin cells from oxidative DNA damage & mitochondrial degradation and promote wound healing. Exciting potential for skin health! #Science #Research #WoundHealing #Biotechnology
https://t.co/4hs5vggmV3
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Our current exhibition, 'Ink's Infinite Inspiration,' features beautiful Chinese brush paintings by Lu Zhongjian, who is widely recognised as one of the finest painters in southern China. The free exhibition remains open until 22 August 2024 in Clare Hall’s Main Building.
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Our preprint on the ALS/FTD-associated RNA-binding protein FUS’s role in axonal development has now been published in Journal of Neuroscience! We show that expression of FUS variants compromises the integrity / complexity of the distal axonal cytoskeleton. https://t.co/rnMSfAuvzv
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https://t.co/qCMM8kugTS Here, understanding and learning are seen as the coherent integration of new tokens with existing manifolds, leading to smooth and stable manifolds for seamless incorporation of new information. Unstable or erratic geodesics indicate poor understanding.
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https://t.co/qCMM8kugTS Thought flow as the sequential activation of tokens along geodesics within these manifolds. Consciousness perceives thought flow, evaluates it against predictions, and provides feedback through prediction errors, restructuring the geometry of intelligence.
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https://t.co/qCMM8kugTS Proposes a general framework based on Riemannian geometry to describe the structure and dynamics of intelligence. Conceptualises intelligence elements as tokens embedded in a high-dimensional space, forming manifolds that capture interconnections.
arxiv.org
Understanding intelligence is a central pursuit in neuroscience, cognitive science, and artificial intelligence. Intelligence encompasses learning, problem-solving, creativity, and even...
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🚀Excited to share my mew work on the structure and dynamics of Intelligence based on Riemannian Geometry https://t.co/qCMM8kugTS the geometry guides how the consciousness navigate, the consciousness dictates how the geometry evolves. 📖🔗 #AI #Neuroscience #CognitiveScience
arxiv.org
Understanding intelligence is a central pursuit in neuroscience, cognitive science, and artificial intelligence. Intelligence encompasses learning, problem-solving, creativity, and even...
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A heartfelt thank you to everyone in LAG and MNG, especially the wonderful mentorship from Gabi and Clemens! A mix of emotions as I bid farewell to the incredible teams at @group_laser and @mng_ceb. My 7-year journey as here has been nothing short of extraordinary! Miss you all!
Bittersweet farewell for our great @LuMeng2020, the godfather of organelle imaging and post doc for 7 years in @group_laser and @mng_ceb. On to great new things, Prof. Lu, and off to a cracking career in @PKU1898! Well done, Meng, and richly deserved! @cebcambridge
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Bittersweet farewell for our great @LuMeng2020, the godfather of organelle imaging and post doc for 7 years in @group_laser and @mng_ceb. On to great new things, Prof. Lu, and off to a cracking career in @PKU1898! Well done, Meng, and richly deserved! @cebcambridge
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Huge congratulations to our fearless leader Gabi for her hugely deserved promotion to grade 12 Professor in Molecular Neuroscience. Fantastic news! Recognition of a star neuroscientist and the fantastic crews of @mng_ceb and @group_laser in @cebcambridge .
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📢 Just published in @CommsBio 📚🔬our latest study investigates the interaction, in IPSC-derived neurons, between α-Synuclein proteins & physiological lipid membranes (synaptic vesicles), shedding light on its role in Parkinson's disease. https://t.co/MRE420X1Yh
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α-synuclein (aSyn) interactions with physiological lipid membranes lead to: 1⃣Membrane disintegration 2⃣ Lipid incorporation by aSyn fibrils 3⃣ Increased fibril aggregation 4⃣ Increased neuronal uptake of lipid-associated fibrils (vs. aSyn-only) @mng_ceb
https://t.co/V6403cyGgU
nature.com
Communications Biology - Interaction of alpha-synuclein (aSyn) with physiological lipid membranes leads to the disintegration of membranes, incorporation of lipids by aSyn fibrils, increased...
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Great question and great work from @chongxi_lai , it is a solid scientific study on free will!
1/ Story time! Can rats control their thoughts? Can they think about a remote place distant from their current location, just like we do?
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1/ Story time! Can rats control their thoughts? Can they think about a remote place distant from their current location, just like we do?
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It is my great pleasure to work in @group_laser and @mng_ceb to publish ERnet! Thank you for your wonderful contributions @charlesnchr @AvezovL @pl219_Cambridge and Jana Weber @NLaeubli @KMScherer !
Super well done, @LuMeng2020, especially! Nice collaboration involving @group_laser, @mng_ceb, @AvezovL, @pietrolio, @LapkinLab in @cebcambridge to elucidate the intricacies of the ER and use it for advanced phenotyping. #ERNet #CellBiology
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🧪🔬 We have developed ERnet, a new analysis software to detect subtle phenotypes in the endoplasmic reticulum (ER), a crucial cellular organelle. ERNet, just out in @Naturemethods, will empower drug & genetic screening processes. #Cambridge @group_laser @mng_ceb
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Check out our news feature highlighting our findings on the overlooked role of #water #mobility and #cellular #environment to #Parkinson’s disease!
cam.ac.uk
When attempting to discover potential treatments for protein misfolding diseases, researchers have primarily focused on the structure of the proteins themselves. However, researchers led by the
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wonderful work from molecular neuroscience group! @mng_ceb://www.cam.ac.uk/research/news/slow-moving-shell-of-water-can-make-parkinsons-proteins-stickier
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It’s finally out! I’m so proud of this paper. Slightly controversial and may ruffle a few feathers. The role of water in the solvation shell during protein misfolding is often overlooked, but contributes to the aggregation propensity of proteins
Just out in @angew_chem Decreased Water Mobility Contributes To Increased α-Synuclein Aggregation using #terahertz spectroscopy we show high charge density ions reduce water mobility, contributing to increased aggregation due to reduced #protein mobility https://t.co/KMSjDgVq9s
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