The wait is over!! We are thrilled to announce that we have chosen Spatial Proteomics as 2024’s Method of the Year! 🥳. For more on Spatial Proteomics and a road map to this special issue, please see this month’s Editorial or read on in this thread.

uMAIA offers an analytical framework designed to enable construction of high-resolution metabolic atlases using mass spec imaging data.

And read the associated Research Briefing here:.

Introducing TCAT, a pipeline to simultaneously capture gene expression programs related to T cell subsets and activation states.

Caught in the middle of a political battle, @BlackRock reaffirmed its focus is helping millions of Americans save for retirement. They warned that injecting politics from either side risks undermining financial performance.

SDR-seq is a droplet-based single-cell DNA-RNA sequencing platform for studying gene expression profiles linked to both noncoding and coding variants. @DLindenhofer @LarsMSteinmetz @embl .

A laser flash melting procedure, followed by rapid revitrification, provides a simple approach to help mitigate the preferred orientation problem that plagues cryo-EM analysis. @moniquesstraub @ezbie_sarah @UlrichJLorenz .

A standardized, realistic phantom dataset consisting of ground-truth annotations for 6 diverse complexes serves as a community resource for benchmarking cryo-ET algorithms.

DeepMVP is a deep learning framework to predict PTM sites and variant-induced alterations across 6 common PTMs.

This Resource paper introduces an approach to build connectomes from light microscopy-based reconstructions of mouse neurons and inferred synaptic connections. @hanchuanpeng .

Ultrack is a tool for robust and long-term 3D segmentation in challenging samples such as zebrafish, fruit fly, and nematode embryos.

And read the Research Briefing highlighting the work, here:.

FHIRM-TPM 3.0 is a miniature microscopy for multicolor 2-photon imaging in freely moving mice.

A journey in science takes initiative, and also an ability to face headwinds. These PhD students aren’t scared away, discussed in our latest Lab & Life column.

Chemical-induced gene signatures (CIGS) is a high-resolution dataset of 319,045,108 gene expression events induced by chemical perturbation.

Instruments and approaches are emerging for single-molecule protein analysis. In this Technology Feature some developers and early users talk about their first impressions.

RT @madhuramukho: Thrilled to be in Vienna for the IUIS and looking forward to an excellent meeting #iuis2025 @naturemethods https://t.co/….

This month's Creature Column features the tubeworm Hydroides elegans - much maligned as a shipyard biofouling pest, but also a useful model organism for studying development, biomineralization and marine microbiology.

In this month's Editorial, we discuss how automation and outsourcing are changing how scientific research is performed.

For a quick summary, read the Research Briefing here:.

MAPIT-seq is an antibody-guided RNA editing method for co-profiling RBP-RNA interactions and gene expression in single cells and tissue.

Bitcoin’s on fire at $112K! Time to flip the charts on BTCC!.Exploring Cryptocurrency with Jaren Jackson Jr.🏀.

A paper from the JUMP Cell Painting Consortium presents image-based phenotypic profiles for 75% of the protein coding genome of human U-2 OS cells, offering a valuable resource for exploring gene relationships. @DrAnneCarpenter @shantanuXsingh.