Molecular Neuroscience Group
@mng_ceb
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The Molecular Neuroscience Group in the University of Cambridge focuses on investigating the molecular mechanisms that cause neurodegenerative diseases.
University of Cambridge
Joined October 2019
Hello! 🌟 We're officially moving to bluesky today 📅 Stay updated with all our science news via @ https://t.co/04Gj8HwFPN! 📢🔔
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✨ Excited to see our FLIMPA preprint shared! 🙌Thank you for the support! FLIMPA is an open-source tool for advanced phasor plot analysis in FLIM data, offering a powerful alternative to proprietary software. 📊🔬 👉 https://t.co/esm1F8yPXC
#Microscopy #FLIM #OpenScience
biorxiv.org
Fluorescence lifetime imaging microscopy (FLIM) is an advanced microscopy technique capable of providing a deeper understanding of the molecular environment of a fluorophore. While FLIM data were...
FLIMPA: A versatile software for Fluorescence Lifetime Imaging Microscopy Phasor Analysis https://t.co/CzfXTXpapb
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Thrilled to share our new study! Sea cucumber extract can protect skin cells from oxidative DNA damage & mitochondrial degradation and promote wound healing. Exciting potential for skin health! #Science #Research #WoundHealing #Biotechnology
https://t.co/4hs5vggmV3
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7/ 🙏: @LuMeng2020, @Ernestine_Hui, Marius Brockhoff, Jakob Träuble, @AnaisFerVilleg, @OJBurton, Jacob Lamb, @edward_n_ward, Philippa J Woodhams, Wadood Tadbier, @NLaeubli, @AntLomb
@mng_ceb @lombardo_group @TheHofmannGroup @group_laser @mng_ceb @GrapheneUCam @SensorCDT
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6c/ 🚪 Provides a new toolset not only for the study of synaptic dysfunction, loss, and increase in models of #neurodegenerative diseases, but opens the doors for models of #schizophrenia and #epilepsy
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6b/ 🧠 Employed 4D SIM to permit the spontaneous examination of individual neuronal ultrastructures and their correlated structural changes for the first time
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6a/ Why is this important ? 🥇 First demonstration of the combination of graphene, super-resolution microscopy, and machine learning to investigate neurodegenerative diseases
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5/ 🔎 So, what did we find? 🌍 On a global level: substantial neuronal degeneration over time was induced ⏫ On a sub-neuronal level: synaptic boutons significantly increased in size Both leading to a loss in neuronal signalling capacity! ⚡
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4/ 💻To help us quantify disease progression, #machinelearning was used for spike sorting and determining factors such as spike rate and spike frequency
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3/ 🔬 We combine our G-MEAs with high-resolution #microscopy, such as 4D structured illumination microscopy, to investigate what happens when we treat hippocampal neurons with an intracellular cholesterol transport inhibitor – mimicking Niemann-Pick disease type C
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2/ 💡Did you know #graphene is electrically conductive AND transparent (97.7% in the visible light spectrum!) We leverage these properties to make extremely transparent graphene microelectrode arrays (G-MEAs), where we can image and record neuronal signals simultaneously
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🧵: 1/ How can graphene, super-resolution microscopy, and machine learning help us to understand the brain? 🧠 Find out more in our new paper in Advanced Science! 👇 https://t.co/ZikzVDFguX
@AdvPortfolio @cebcambridge @GrapheneUCam @GrapheneEU @Cambridge_Uni #Grapheneweek2024
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Our second year student at their poster presentation at the CEB conference. Well done🤩👍🫶
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We are also very proud of our students from MNG at the CEB conference. Congratulations! Big thank you to Gabi and everyone else who have helped to make this conference happen! 🤗🤗🤗@cebcambridge
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Last week we had our third year PhD students from @group_laser presenting at the annual CEB conference, well done everyone!! And huge congratulations to Anna @AScheeder for winning the best presentation prize 🎊🎊
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🎉 Huge congrats to Dr. Hui @Ernestine_Hui for acing the thesis defense! 📚👏 Your dedication and brilliance shine through. Wishing you endless success and impactful contributions ahead! 🌟
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Christmas Dinner with @group_laser and @mng_ceb, brilliantly organised by our lab newbies. Lovely evening, despite the vicious gift exchange and cruelly difficult Santa quiz. On to great new adventures in the New Year!
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Congratulations👏 and shoutout to our @AnaisFerVilleg for her stellar contribution 🌟
Detecting ion channel activities just from neuron membranes‼️‼️😮 Check out our new work on Advanced Science : https://t.co/3wl5zt2KSh 🎉My deepest gratitude goes to my supervisor and dear colleagues! @biochemist_hero @barberio_chiara @AnaisFerVilleg @KKallitsis @achilleas_savva
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