Wu Lab at UTHealth
@LongJun_Wu
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Neuroimmune interaction in health and disease @McGovernMed @UTHealthHouston
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Celebrating Wu Lab 10 years anniversary. Extremely grateful to lab members and alumni from Rutgers and Mayo for the tremendous contribution! Such a memorable and exciting journey with each of you! Science is beautiful but friendship is even more. Look forward to next milestones!
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Extremely excited to announce that Wu Lab is moving from Mayo Clinic to University of Texas Health Science Center at Houston by this September! Wu lab
@UTHealthHouston
will be a founding member of the new Center for Neuroimmunology and Glial Biology (CNG)!
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3
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Great to kick off the new year by sharing our study on how microglia promote neuronal activity after anesthesia, published today in
@NatureNeuro
. Tremendous effort led by postdoc
@KoichiHaruwaka
& Yanlu with strong support
@GregoryWorrell
@MayoClinicNeuro
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Glad to share our new study on microglial TREM2 clearance of TDP43, published today in
@NatureNeuro
. We found that TDP43 directly binds TREM2. Tremendous efforts led by Manling and Yong with strong support from
@guojunbulab
, Mark Mattson and many others.
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Extremely excited that we are awarded 8-year NINDS R35 grant on how microglia sense and regulate neuronal activity! Truly appreciate the strong support
@NINDSfunding
! Grateful to all former and current lab members for tremendous contributions and tireless work in past 11 years!
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Many congrats
@TonyUmpierre
on his work studying P2y6 in microglial Ca signaling and phagocytosis, published in
@NeuroCellPress
today! Thanks
@yulonglilab
for generating the first UDP sensor to detect UDP release in vivo and UDP-P2y6 in microglial Ca pathway and epileptogenesis.
Final postdoc paper is out! We evaluate the mechanism behind microglial calcium signaling in early post-injury epilepsy development. UDP activation of the P2Y6 calcium pathway plays an outsized role in inflammation and phagocytosis
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Wu lab summer party to celebrate recently awarded three NIH funding (R35, R01, R33). Extremely grateful to
@TonyUmpierre
@Manling_Xie
@MinHeeYi2
for leading the respective projects! Thanks
@aastha_dheer
@AbhijeetBarath
for organizing the event! So much fun in team building 💪😆
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Extremely excited to host the Inaugural Symposium on Neuroimmunology and Glial Biology
@UTHealthHouston
on 4/26. The symposium honors life of immunologist Dr. Muller-Eberhard, the first director of Institute of Molecular Medicine. Please join us with leading experts in the field!
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Using in vivo two photon imaging combined with electron microscopy, we found that dynamic microglial processes are able to enter into the synaptic cleft to shield inhibitory synapses, thereby enhancing neuronal activity during the emergence from anesthesia by isoflurane.
Great to kick off the new year by sharing our study on how microglia promote neuronal activity after anesthesia, published today in
@NatureNeuro
. Tremendous effort led by postdoc
@KoichiHaruwaka
& Yanlu with strong support
@GregoryWorrell
@MayoClinicNeuro
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Great work from
@aastha_dheer
on microglial chemogenetics and seizures. Acute activation of microglia Gi signaling reduced seizures while chronic activation increased neuronal death.
Article alert!! Happy to share our recent work employing Gi-Dreadd manipulation of microglia to explore their role in regulating seizures.
#gliaresearch
#microglia
#epilepsy
#chemogenetics
#Neuroscience
@LongJun_Wu
@BrainBehavImm
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The first glioma paper from Wu lab, led by talented PhD student Fiona
@FionaJiaying
@MayoGradSchool
. Appreciate the strong support from Mayo community on glioma research
@DoctorQMd
@DrAaronJJohnson
X-less Dr. Haidong Dong and their team members
@MayoClinicNeuro
Super excited to share our new paper about TREM2 roles in glioma! Big thanks to my amazing team for their great support. And one step closer to finishing my PhD 😆
@LongJun_Wu
@MayoGradSchool
@NeuroOnc
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Wu lab at Mayo is recruiting postdocs and research scientists. For those who are interested in glia and neuroimmune research, please visit and email wu.longjun
@mayo
.edu.
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Many congrats on Fiona’s excellent PhD defense today! She is so brave and talented, spearheading the completely new research direction on glioma research in the Wu lab. Thanks committee members
@DrAaronJJohnson
@Da_Mesquita_S
, Dr Vile, Dr Scarisbrick for the tremendous support!
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4
64
Probably the last gathering of Wu lab at Mayo. Thanks everyone for your contributions to our research excellence
@MayoClinic
in past 7.5 years, particularly our amazing collaborators
@GregoryWorrell
and Dr Lennon. We look forward to the next chapter of Wu lab
@UTHealthHouston
!
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Great to share our review on "Tuning neural circuits and behaviors by microglia in the adult brain" published in Trends in Neuroscience. An emerging topic with
many excellent studies. Appreciate leading efforts
@ShunyiZhao_
@MayoGradSchool
@TonyUmpierre
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Microglia are on fire! Beautiful cover image from amazing PhD student
@ShunyiZhao_
. It’s 3D reconstructed 2p image of microglia (blue) interacting with cortical neurons and apical dendrites (red). The first ever cover from the Wu lab 😀
March 2024 issue of Trends in Neurosciences:
Free featured articles & more:
On the cover: ‘Tuning neural circuits and behaviors by microglia in the adult brain’, by
@ShunyiZhao_
,
@TonyUmpierre
&
@LongJun_Wu
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Thank you for the kind invitation
@BIG_CenterWashU
@jonykipnis
and for hosting my visit
@TristanLi_Lab
Glad we fixed glitches of microglia movies during the talk 😅 Really enjoyed the discussions on amazing BIG science with faculty and students! 😎
Fantastic lecture today by
@LongJun_Wu
during his visit
@BIG_CenterWashU
on how microglia sense neurons and what do they do to them! 👍🤩👏 Thank you for visiting us and sharing your great science with us.
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Tremendous honor to host the 1st Hans J. Muller-Eberhard Symposium on Neuroimmunology & Glial Biology
@McGovernMed
! Really enjoyed the enriching discussions. Thanks all speakers and attendees for making it so exciting. Thanks CNG staff
@CNG_UTHealth
for the meticulous efforts!
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We started the project to study microglia functions in behaviors, but ended up finding the hypolocomotion is independent of microglia 😅 Thanks talented
@ShunyiZhao_
@FionaJiaying
for leading the project! Appreciate strong support from
@KAyasoufi
@DrAaronJJohnson
@MayoGradSchool
My paper about chemogenetic manipulation of CX3CR1+ cells is finally out
@molpsychiatry
! Big shout out to co-first
@FionaJiaying
and the team! Very grateful for all the support from my PhD mentor
@LongJun_Wu
!
Please check it out if you are interested!
👉
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So proud of Manling being the first PhD student graduated from the Wu Lab at Mayo. Manling is such a talented student we are lucky to have! Many congrats, Dr. Xie! Thanks committee members
@DrAaronJJohnson
@johnthefryer
@guojunbulab
, Dr Choi and Dr Lennon for the amazing support!
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Happy Chinese New Year! Great fun to take half day off celebrating it after lab meeting 😂😂😂🎉🎉🎉
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We are honored to have Dr. Marco Prinz from University of Freiburg virtually present for Glia and Neuroimmune Seminars at Mayo Clinic on Tuesday October 25th. Thanks
@biocytogen
@MayoClinicNeuro
and Mayo Center for MS and Autoimmune Neurology for sponsoring the event.
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6
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First time attend Mayo commencement ceremony. Announce Wu lab at Mayo first PhD graduate, Dr Manling Xie!
@Manling_Xie
Many congrats again, Manling! You are such a role model for all trainees. We are very proud of you!
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We are honored to have Dr. Li Gan
@LiGanLab
from Weill Cornell Medicine virtually present for Glia and Neuroimmune Seminars at Mayo Clinic on Tuesday March 22. Thanks
@biocytogen
and Mayo Center for MS and Autoimmune Neurology for sponsoring the event.
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9
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We are honored to have Jony
@jonykipnis
virtually present for Glia and Neuroimmune Seminars at Mayo Clinic on March 23. Thanks
@biocytogen
and Mayo Center for MS and Autoimmune Neurology for sponsoring the event.
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6
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Glad to share our study on board-associated macrophages (BAM) published
@CellReports
! The work was spearheaded by talented PhD student Lingxiao
@LWang357
@MayoGradSchool
We found CCR2+ monocytes are able to replenish resident BAMs when they were depleted or lost under diseases.
BAM: CCR2+ monocytes replenish border-associated macrophages in the diseased mouse brain:
@CellReports
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Wu lab has strong presence at
#SfN2023
, with 15 members attending in person! Here is the list of posters on various microglia research.
@TonyUmpierre
oral presentation on microglia P2Y6 is on Sunday. We are still recruiting postdocs! Come to meet with us if you’re interested 😀
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So glad to be back to University of Toronto
@UofT
where I finished my PhD 20 years ago! All sweet memories came back. Excited to catch up with my former mentor Dr. Min Zhuo and life-time friend Dr. Graham Colligridge!
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What an inspiring talk by Dr Virginia Lee today! She discussed the important discovery on the propagation of misfolded proteins in neurodegenerative diseases. Really enjoyed the talk and discussions!
@MayoClinicNeuro
@MayoGradSchool
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We are honored to have Dr. Alfonso Araque from University of Minnesota virtually present for Glia and Neuroimmune Seminars at Mayo Clinic on Tuesday August 23rd. Thanks
@biocytogen
and Mayo Center for MS and Autoimmune Neurology for sponsoring the event.
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It’s a great honor to be with Dr Mattson
@NIHAging
@JohnsHopkins
at his Brain Ponderings podcast for general audience interested in neuroscience. Our conversation on microglia goes quite deep. Thanks Dr Mattson’s insight questions and tremendous efforts!
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Wu lab spring gathering this weekend. A lot to celebrate, and welcome new members!
@YushanWww
@YamNathPaudel2
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Thanks
@KoichiHaruwaka
@MinHeeYi2
@aastha_dheer
@FionaJiaying
@AbhijeetBarath
@ShunyiZhao_
for the fabulous presentations today
#SfN2023
. Always great meeting up Wu lab star alumnus Prof Eyo
@eyolab
So proud of you all!
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Happy holidays! We enjoyed great time at the Wu lab Christmas party. Thanks Dale for the tremendous contribution in the past 6 years! Thanks
@AbhijeetBarath
@aastha_dheer
for organizing the event!
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On the way
#Euroglia
Really excited to meet many friends in Berlin! Look forward to the great session on
#microglia
with
@hayleystrasburg
, Junichi, and Marcus. Our session is on Sunday morning. Hope to see you all there!
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The new Center for Neuroimmunology and Glial Biology (CNG)
@UTHealthHouston
has multiple tenure-track faculty openings. Join us for this exciting new adventure! Please apply online or email me directly.
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We are honored to have Dr. Virginia Lee from
@PennMedicine
present for Glia and Neuroimmune Seminars at Mayo Clinic on Tuesday October 24th. Thanks
@biocytogen
@MayoClinicNeuro
and Mayo Center for MS and Autoimmune Neurology for sponsoring the event.
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So glad to meet
@SfNtweets
#SfN2023
Thank you for the kind words
@eyolab
What an honor to work with you and really miss the great time together! You set the bar high for all trainees 🤣Amazingly productive: 4 kids and 10 first-author publications within 6 years! 👍
Eleven years ago, this guy (
@LongJun_Wu
) took the chance to accept me to join his lab. What an incredible experience with him as a postdoc for 5.5 years (& 19 papers: dude will work you🤓). Great to meet at
@SfNtweets
and see the fantastic work his group continues to produce🫡
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Happy New Year! Wish you all have a happy and productive 2023. Truly grateful for working with such an amazing group!
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We are honored to have Dr. Dandan Sun from University of Pittsburgh present for Glia and Neuroimmune Seminars at Mayo Clinic on Tuesday February 28th. Thanks
@biocytogen
@MayoClinicNeuro
and Mayo Center for MS and Autoimmune Neurology for sponsoring the event.
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Happy Chinese New Year from Thailand! Thanks Prof Supin for the kind invitation, and met many energetic young scientists at Mahidol University!
@MahidolU
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Can’t wait to start today the exciting program on Neuroimmune interactions in beautiful Obergurgl, Austria! Thanks
@rosa_paolicelli
@anne_roumier
and Marco Prinz for organizing the course.
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Great to have
@YangYangPhD
and
@NNaveenutah
visit our lab
@MayoClinicNeuro
to discuss exciting microglia research and collaborations! Thank you, Yang and Naveen!
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Wu lab is presenting 6 posters this afternoon! Please come to find us now at D17-D21 😀
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Cool study done by Min-Hee on microglial optogenetics published in
@PLOSBiology
. We now have both chemogenetic and optogenetic tools to specifically manipulate microglial activation in vivo. Great work
@minheeyi1
!
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Thank you Dr Koroshetz
@NINDSdirector
for raising the awareness and for your strong support for Asian community! Still remember your inspiring speech in 2019 SfN Chinese Neuroscientist Social. Inequality is hurting science and is wrong!
Something's wrong: Underrepresentation of Asian awardees of United States biomedical research prizes
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Many congrats to
@MinHeeYi2
on tenure-track faculty position at Chungnam National University in South Korea! Thank you for the great memories and hard work in the past 6 years in Wu Lab. Your talent, smile and kindness will be sorely missed. Wish you all the success, Min-Hee!
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Totally agree! Such a pleasure to meet with great friends, talented trainees, and amazing science
#microglia
. Look forward to the next conference
@FENSorg
#microglia
is the best research field ever: all friends, no competition, just pure scientific challenge and tons, tons of fun
@anne_roumier
@LongJun_Wu
@DenesLab
@Michela30586273
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Happy thanksgiving! Truly grateful for having all of you!
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Really excited to meet with so many friends at UVA
@eyolab
@Jie_Immunology
@LukensJohnR
@JCoutinhoBudd
@tajieharris
@hui_zong
@BIG_Center_UVA
Enjoy the UVA tour! Special thanks to Eyo for hosting visit and so proud of the amazing microglia research in the Eyo Lab!
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Microglia states and nomenclature: A field at its crossroads. Now out in
@NeuroCellPress
. Tremendous efforts by
@SierraLabAch
@rosa_paolicelli
@LaboTremblay
@stevens1lab
and microglia community!
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Yes, the amazing dynamics of microglia draw me to the field when I started my postdoc 18 year ago. Still enjoy looking at their highly motile processes touching all elements in the brain 🤣
Quotation of the day at the
@FENSorg
#winterschool
:
"Looking at
#microglia
response to
#ATP
is so satisfying"
@LongJun_Wu
😂 100% agree
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Our recent paper on microglial process pouches in seizures. Appreciate very much the amazing work done by
@eyolab
@KoichiHaruwaka
and the team. Here is the exciting story behind the discovery by
@eyolab
when PI is away 😂😂😂
Every paper I have published from my Postdoc began with an unintended observation that I pursued with great interest. Every. Single. One. This was no exception. Here’s a “behind-the-scenes” Tweetjourney of this study😁: . 1/8
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From science to karaoke at
#FENS
-Hertie
#WinterSchool
on “Neuro-immune interactions in health and disease”
@LongJun_Wu
@SoniaGarel
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Thank you for the great contribution, Madhu! Microglia ion channel is an extremely cool topic. I feel honored to edit the book with my PhD mentor Prof. Tian-Le Xu. Appreciate the amazing support from many colleagues
@zppang
@LabJiang
and tweetless friends.
I am happy to contribute a chapter describing Hv1, a proton channel that was only recently discovered. I author the chapter with
@LongJun_Wu
, one of the Editors of this book and a long-time mentor.
#Neuroscience
#Taylor
&FrancisGroup
#RutgersNeurosurgery
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Sad to see this. We all understand the challenge, but
@SfNtweets
should provide the option for the full refund particularly for trainees. Our lab has 3 PhD students and 4 Postdocs registered the in person meeting. SfN should be more considerate and supportive!
The Society for Neuroscience will hold
#SfN21
as a fully virtual experience, eliminating all in-person options that had been planned for McCormick Place in Chicago, Illinois.
See our October 8 statement for more details.
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My extremely talented postdoc Tingjun and his family have been stuck in Mexico for more than four months due to the visa issue since April. Please sign the petition if you could. Thank you all in advance for your strong support!
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Many congrats
@TonyUmpierre
on K99 award studying microglial calcium signaling in seizures! The award will pave the way for his independence. Thanks all for the support! Very proud of his achievements!
Pretty excited to have this funding and a shot at being independent in a year or two! Thanks to all the mentors and people who wrote me a letter of rec. I couldn’t have done it without your support.
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Beautiful study from
@ZhaoNaa
and Bu lab on dynamic TREM2 functions in AD pathogenesis. The inducible mouse model expressing human TREM2 and R47H mutant in microglia is powerful. Glad to be part of the exciting work!Thanks talented student
@FionaJiaying
for chronic 2p imaging!
Very excited to share our work showing the importance of TREM2 expression during amyloid seeding stage!
@JExpMed
@LongJun_Wu
@MayoClinicNeuro
@MayoClinic
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Thanks talent PhD student
@FionaJiaying
for representing Wu lab at
#immunology2022
! And many congrats her on winning 2022 AAI Trainee Award! Fiona spearheaded the first glioma project at Wu lab with generous help and guidance from
@DrAaronJJohnson
and
@DoctorQMd
. Thank you all!
Hello Portland! Hello 2022 AAI!
Excited to be here for my first
#immunology2022
conference! If you’re interested in the proton channel regulating myeloid infiltration in the brain tumor, come check out my poster (May 7th, Saturday) and talk (May 9th, Monday)!
#AAI2022
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Thank you and Eyo
@eyolab
for participating in the symposium
@CNG_UTHealth
. The discussions are just inspiring!
Honored to be present for the inaugural Eberhard Symposium at the brand new Center for Immunology & Glial Biology at UT Houston! Thank you
@LongJun_Wu
and
@eyolab
for including me. So many amazing speakers. Thrilled to see lots of exciting glia research coming to Texas 🥳
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We are
@MayoGradSchool
Fair Booth
#23
Please stop by to know more about Mayo NSC PhD program, MD-PhD program, SURF, Post-bac, and Graduate Research Education Program. There are many Postdoc openings as well! I will be here till 2pm to answer questions
@SfNtweets
😆
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We are honored to have Tuan
@painandpoppies
virtually present for Glia and Neuroimmune Seminars at Mayo Clinic on Tuesday September 28. Thanks
@biocytogen
and Mayo Center for MS and Autoimmune Neurology for sponsoring the event.
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We are honored to have Dr. Yongjie Yang
@Yanglab_Tufts
from
@TuftsMedSchool
present for Glia and Neuroimmune Seminars at Mayo Clinic on August 22nd. Thanks
@biocytogen
@MayoClinicNeuro
and Mayo Center for MS and Autoimmune Neurology for sponsoring the event.
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We are honored to have Bal
@baljit_khakh
virtually present for Glia and Neuroimmune Seminars at Mayo Clinic on Tuesday June 22. Thanks
@biocytogen
and Mayo Center for MS and Autoimmune Neurology for sponsoring the event.
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Thank you for the nice pictures
@anne_roumier
I am like a rock star (fake one 😂) but everyone is fantastic! The best science feast and karaoke party ever!
@FENSorg
Happy and moving like a
#microglia
sensing
#ATP
😁 at the
#karaoke
party of our
#FENS
#winterschool
@LongJun_Wu
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Fantastic news reports from Discovery's Edge
@mayoclinc
as well as from BioArt
@BioElife
on our work regarding microglial TREM2 in TDP-43 neurodegeneration
@NatureNeuro
. Extremely grateful to
@SaraTiner
for writing up the story!
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Thanks Shaoyu and Qiaojie for the invitation! The harbor, seafood and campus at the long island are just beautiful. Always great meeting with many friends and discussing exciting science! Thanks graduate students for asking amazing questions and enthusiasm on microglia research.
Join us on TODAY, Thurs, May 4, 12pm at LSB 038 for our next series speaker, Dr. Long-Jun Wu (
@LongJun_Wu
) from Mayo Clinic, College of Medicine! He'll be discussing "Neuroimmune Interactions: How Microglia Sense and Regulate Neuronal Activity."🔬📷
#neuroscience
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Such a great experience attending undergraduate research symposium
@uwgb
. Thanks Whitney and
@ShunyiZhao_
for representing Mayo Neuroscience PhD program
@MayoGradSchool
@MayoClinicNeuro
We have enormously vibrant research and amazing students. Please consider joining us!
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Really enjoyed the meeting and discussions! Thanks
@ISMND1
@_BrightFocus
@MolNeuro
for organizing such an exciting event. Great feast on glia and neurodegeneration!
Next up is Long-Jun Wu
@LongJun_Wu
@MayoClinic
presenting their talk ‘TREM2 mediates microglial neuroprotection against
#TDP43
neurodegeneration’
#microglia
#ISMND2022
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Really enjoy the meeting and discussions! Timely theme on team science and collaboration to promote the translational efforts. Thanks for organizing the exciting event
@freemanwd
@KevinMBarrettMD
@DoctorQMd
@MayoClinicNeuro
#NeuroscienceConvergence2022
Day
#1
in books.
@LongJun_Wu
spoke about the the incredible role microglia play in TDP-43 and CNS neurodegenerative diseases
@KevinMBarrettMD
@MayoClinicNeuro
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Welcome to Mayo Neuroscience PhD program!
Welcome to the Mayo Clinic Graduate School of Biomedical Sciences! Pictured are some of the incoming students in the Neuroscience (NSC) track getting to know each other over lunch.
#neuroscience
#newPhDstudents
#MCGSBS
#MayoClinic
#MayoGradSchool
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We are honored to have Anna
@AnnaMolofskyLab
to virtually present for Glia and Neuroimmune Seminars at Mayo Clinic on September 22. Thanks
@biocytogen
and Mayo Center for MS and Autoimmune Neurology for sponsoring the event.
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“We urge the federal government to shift away from deterrence and fear and instead focus on the philosophies that have made the United States a global leader in science and technology: openness, diversity, and international collaboration.”
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Seeing so many black trainees in the
#BRIDGE
poster session and so many “big shot” PIs engaging with them at their posters. Incredible impact. Just incredible!!! Also, re-connecting with my postdoc mentor (
@LongJun_Wu
) and inspiring colleague (
@AmyLBrewster
). Great meeting!!!
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@NIH
and
@NINDFunding
awards, such as the T32 grant, provided Dr. Ukpong Eyo access to strong mentorship, which helped him receive a K22 award and become an independent scientist. Read
@eyolab
’s story here:
#ResearchDiversity
#NINDSMentoring
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We are honored to have Dwight to virtually present for Glia and Neuroimmune Seminars at Mayo Clinic on November 24. Thanks
@biocytogen
and Mayo Center for MS and Autoimmune Neurology for sponsoring the event.
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Very excited that postdoc Yong secured an offer of Assistant Professor from National University of Singapore today! Since the Wu Lab started in 2012, three postdoc trainees Jiyun Peng, Ukong Eyo
@eyolab
and Yong Liu now are independent and lead their own labs. Very proud of them!
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Great job, Fiona! Thanks for representing NSC track and the Wu Lab!
The NSC track student
@FionaJiaying
(
@LongJun_Wu
lab) hitting it out of the park at the
@MayoGradSchool
Student Symposium 💪🏻😃
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Great minds think alike
@TawfikLab
! Actually Amanda
@SierraLabAch
and Rosa
@rosa_paolicelli
are leading the efforts on microglia nomenclature. Stay tuned!
A group of
#glia
experts put out a consensus statement on how to define astrocyte reactivity.
Great idea to bring the definitions and language into alignment.
Maybe we need one for
#microglia
next?
@mike_doc_B
@DrPeterGrace
@LongJun_Wu
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Yes! More lab outings and team building to celebrate holidays are great 👍
Happy New Year!!! Hope our new papers can be like:
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Long time no see, Paul. The image is very cool! Eyo’s early work in our lab showed that neuronal hyperactivity attract microglia interactions, which could in turn dampen neuronal activity in seizures.
question for glia people--
what is the significance of the apparent soma-soma interactions between microglia (white) and neurons (red)?
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We are honored to have Dr. Lucas Cheadle
@LucasCheadle
from Cold Spring Harbor Laboratory
@CSHL
present for Glia and Neuroimmune Seminars at Mayo Clinic on May 23rd. Thanks
@biocytogen
@MayoClinicNeuro
and Mayo Center for MS and Autoimmune Neurology for sponsoring the event.
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What is the role of microglia/macrophages in cancer neuroscience? 😝😂
Had a great time meeting new friends and presenting my work at
#SNO2022
.
@MayoClinicNeuro
@MayoGradSchool
Thoroughly impressed by Cancer Neuroscience❤️
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@McGovernMed
@UTHealthHouston
Immensely grateful to the Dean John Hancock
@McGovernMed
and Neurology Chair Dr McCullough
@LD_McCullough
for the generous support! Also, much appreciate the tremendous help from Dr Tong
@QingchunTong
, the Associate Director of the CNG. Look forward to working with you all!
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Thanks! Have been greatly enjoying the amazing discussions with all of you
@jfcryan
@rolls_asya
@anne_roumier
@Pluchinolab
and trainees
@FENSorg
Some of the great faculty at the
@FENSorg
-Hertie Winter School on neuro-immune interactions
#FENSWinterschool23
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Thanks for your kind words, Vivianne
@tawfiklab
. I am glad that you guys like the work. Email me if you have any questions Love the topic of microglia and pain, and hopefully these new tools are useful for the field. Appreciate the great job done by Min-Hee
@minheeyi1
!
Really engaging JC presentation this morning on the 2 recent papers from
@LongJun_Wu
on
#optogenetic
and
#chemogenetic
manipulation of
#microglia
from
@biorxiv_neursci
led by our amazing undergrads
@juheehvyas
@AyshaGardner
in conjunction with the lab of
@DrPeterGrace
!
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In beautiful Sapporo for the 50th Naito Conference on Glia World. Look forward to the exciting program and discussions in the next 3 days! So glad to meet with many old friends and glial lovers 😀
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Special thanks
@TonyUmpierre
who helped with the R35 grant writing. Tony is K99 awardee and on the job market this year. His current work is super cool on microglial Ca imaging. Any institutes would be lucky to have him as a rising star!
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Beautiful cover art! 👍
Congratulations to my graduate student, Dr. Cori Fain! Cori’s thesis work on CD8 T cell engagement of MHC Class I molecules on brain vasculature being required for lethal BBB disruption in experimental cerebral malaria made the cover of the February issue of BRAIN
@Cori_Fain
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The CNG was recently launched at Brown Foundation Institute of Molecular Medicine
@McGovernMed
. I am absolutely thrilled by this new adventure to be Founding Director of the CNG, and as C. Harold and Lorine G. Wallace Distinguished University Chair
@UTHealthHouston
. Stay tuned!
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Cannot believe this is from 7 years ago! Really miss
@eyolab
Eyo's beautiful research and hilarious singing 😂😂😂
For Teacher Appreciation Week, I’d like to appreciate my Mentor,
@LongJun_Wu
for all he taught me including karaoke-ing as depicted here from 7 years ago.
Disclaimer: Although he is amazing at singing, I was a horrible mentee in this regard.
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Very much appreciate
@TheColonnaLab
for insightful comments! We indeed collaborate with Dr Bo Liang at Emory on crystal structure of binding. Thanks Dr Shugart
@alzforum
for writing up the news story!
TREM2 rallies microglia to respond to TDP-43 aggregates. It may bind TDP-43 directly.
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In the CNS, Hv1 proton channel is expressed only in microglia important for many neurological disorders. However, an interesting study from Jiang and Yang groups recently reported that Hv1 is functional in DRG neurons that contributes to chronic pain.
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This award is just so special! Because it is not only for the PI, but really for the Wu lab team efforts studying microglia-neuron interaction all these years. Thanks all three reviewers for their insightful comments and helpful suggestions!
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Thanks Tony
@TonyUmpierre
for leading the efforts. This is the first microglial Ca imaging paper from our lab. Every excited by the new readout for microglia activity in normal and diseased brain!
Our full microglia calcium article is up! w/ videos & supp. Please check it out (open access). Microglia engage calcium when neuronal activity shifts in the brain, helping to understand why its so low normally.
#neuroscience
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“If America fails to attract top international research talent, that harms U.S. prospects for scientific advancement and, ultimately, American economic and national strength”
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Many congrats again
@eyolab
! I am so glad that you independently carry on the project in a big way. Appreciate Justin and Xiaoliang's pioneer work on microglia-vascular interaction in our lab, though we have not published research articles or secured any grants on the topic yet😂
Today, we received the notice of award for our 1st R01. My name is the only name on the notice but many contributed immensely to make it happen. This is a tweetstory (history) to appreciate some who did and perhaps inspire others who may find possible lessons as well. 1/10.
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Right after 2 hour snow walk. But really enjoyed the great discussions! Thanks for thoughtful questions from faculty and trainees. And appreciate the great opportunity
@FENSorg
@LongJun_Wu
opening the afternoon session with the hot topic of how
#microglia
#sense
#neurons
at
#FENS
-Hertie winter school on
#NeuroImmuneInteractions
in Austria 🇦🇹🏔️❄️
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