Martinez Laurent
@LiMitAging
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Research Director @I2mcT Head @LiMitAging Team "There is a crack in everything, that's how the light gets in"
Toulouse, France
Joined April 2016
A step forward in aging biomarker research from @INSPIREPlatfor1 @I2mcT & @InfinityTLS! For the first time, single-cell measurement of energy metabolism in T cells from a simple blood test can detect risk of functional decline. #IHU_HealthAge @Madam_Mito.
academic.oup.com
Abstract. Aging varies across individuals, highlighting the need for better markers of functional decline. This study investigates the hypothesis that T ce
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RT @brunovellas: Glad to see that paper from our team on Intrinsic capacity Icope step 1 in Nature Aging today
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Excited to share our new study conducted within the @INSPIREPlatfor1 IHU HealthAge: apolipoprotein profiling helps improve prediction of cardiovascular events in the general population @I2mcT @ATH_Plus.
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RT @brunovellas: L’équipe de l’IHU HealthAge en collaboration avec le @BuckInstitute fait partie des 40 équipes semi finalistes du @xprize….
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RT @INSPIREPlatfor1: The impact on research ? : "Mitochondrial segmentation and function prediction in live-cell images with deep learning"….
nature.com
Nature Communications - MoDL, a deep learning algorithm, is developed to link mitochondrial morphology and function. Trained on extensive mitochondrial image and biochemical data, MoDL delivers...
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RT @brunovellas: Implementing the WHO ICOPE program in clinical practice: three years of lessons from monitoring 27,082 participants… https….
pubmed.ncbi.nlm.nih.gov
This study highlights the major role of HCPs in the implementation of the ICOPE program. Self-assessment enables the enrollment of more robust seniors, allowing for an early detection and treatment.
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RT @MitoPsychoBio: If we look at thousands of proteins (i.e., signals) in the human blood, the protein most associated with chronic physica….
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Exited to share our latest review with @SoutoPhilipe.on #Sarcopenia & the biological determinants of aging; Winner is Mitochondrial dysfunction! 🧬 We dive into the role of geroscience in age-related muscle decline.@brunovellas @INSPIREPlatfor1 @I2mcT .
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RT @MitoPsychoBio: The powerhouse analogy has expired. Like social organisms mitochondria differentiate and specialize to accomplish comple….
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Excited to share our collaborative study with @BarteltLab @MoriLabe @HenverBrunetta, now online @embojournal on a novel function of mitochondrial IF1 in thermogenesis. Grateful for the support from IHU HealthAge @INSPIREPlatfor1 @I2mcT @MitoAging .
embopress.org
imageimageHow the hydrolytic activity of mitochondrial ATP synthase is modulated during brown adipose tissue (BAT) thermogenesis remains unexplored. This study demonstrates that reduction of inhibi...
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RT @MitoPsychoBio: The time to think and inquire are precious. Inquiring means to contemplate a problem without needing an immediate answe….
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RT @INSPIREPlatfor1: Congratulations to Y ROLLAND from Toulouse for his last publication about #ICOPE : "Implementing clinical operationali….
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Thrilled to be associated with this study from @BarteltLab, @MoriLab, and the brilliant @HenverBrunetta, uncovering a novel role of mitochondrial IF1 in the reverse mode of ATP synthase, enhancing bioenergetics in brown adipocytes @I2mcT @INSPIREPlatfor1
biorxiv.org
While mechanisms controlling mitochondrial uncoupling protein-1 (UCP1) expression and function in thermogenic adipocytes play a pivotal role in non-shivering thermogenesis (NST), it remains unclear...
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Mitochondrial respiration atlas reveals differential changes in mitochondrial function across sex and age
biorxiv.org
Organ function declines with age, and large-scale transcriptomic analyses have highlighted differential aging trajectories across tissues. The mechanisms underlying shared and organ-selective...
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RT @RouchLaure: Will the Gates Foundation’s preprint-centric policy help open access?
nature.com
Nature - Revised policy says grant recipients must share manuscripts as preprints — and removes support for article-processing charges.
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RT @FrenchPurine: The French Purine Club is happy to introduce you to the speakers for our second Webinar: .Pr. Maria Domercq.Pr. Kenneth….
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What an excellent meeting in Albuquerque covering basic and clinical research in Geroscience @GeroscienceCT.
Start of the ICFSR/Geroscience Task Force in Albuquerque and online!.#mitochondria #geroscience #aging
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In this new study conducted with @metadiab within the #IHUHealthAge, we reported that ApoM decreased with age and negatively associated with insulin resistance .@INSPIREPlatfor1 @I2mcT .
nature.com
International Journal of Obesity - Identification of circulating apolipoprotein M as a new determinant of insulin sensitivity and relationship with adiponectin
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RT @NatMetabolism: Online now! Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcop….
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