Martinez Laurent
@LiMitAging
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Research Director @I2mcT Head @LiMitAging Team "There is a crack in everything, that's how the light gets in"
Toulouse, France
Joined April 2016
Our last paper Is out! We identify plasma apolipoproteins J and L1 as novel determinants of steatohepatitis (MASH) in individuals with obesity — both improving diagnostic accuracy beyond traditional risk factors. #MASH @INSPIREPlatfor1 @I2mcT
link.springer.com
Background Plasma apolipoproteins are linked to cardiometabolic dysfunctions, but their potential as biomarkers for metabolic dysfunction-associated steatohepatitis (MASH) remains underexplored....
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Organ age and mortality in "Plasma proteomics links brain and immune system aging with healthspan and longevity." https://t.co/Czy9zpbsv7
@brunovellas @I2mcT @LiMitAging
nature.com
Nature Medicine - In a large-scale proteomic study of biological aging of 11 organs from 44,498 individuals in the UK Biobank, the biological ages of the brain and immune system emerged as strong...
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A step forward in aging biomarker research from @INSPIREPlatfor1 @I2mcT & @InfinityTLS! For the first time, single-cell measurement of energy metabolism in T cells from a simple blood test can detect risk of functional decline. #IHU_HealthAge @Madam_Mito
https://t.co/vyXK6mJqsE
academic.oup.com
Abstract. Aging varies across individuals, highlighting the need for better markers of functional decline. This study investigates the hypothesis that T ce
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Glad to see that paper from our team on Intrinsic capacity Icope step 1 in Nature Aging today
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Excited to share our new study conducted within the @INSPIREPlatfor1 IHU HealthAge: apolipoprotein profiling helps improve prediction of cardiovascular events in the general population @I2mcT @ATH_Plus
https://t.co/fLmG0tYdtG
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L’équipe de l’IHU HealthAge en collaboration avec le @BuckInstitute fait partie des 40 équipes semi finalistes du @xprize healthspan pour le projet ICOPE INTENSE https://t.co/jLzYTYSgv2
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The impact on research ? : "Mitochondrial segmentation and function prediction in live-cell images with deep learning" https://t.co/5rdz0jqw2c
@brunovellas @isaperarnau @RestoreInstitut @InfinityTLS @I2mcT @LiMitAging
nature.com
Nature Communications - MoDL, a deep learning algorithm, is developed to link mitochondrial morphology and function. Trained on extensive mitochondrial image and biochemical data, MoDL delivers...
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Implementing the WHO ICOPE program in clinical practice: three years of lessons from monitoring 27,082 participants…
pubmed.ncbi.nlm.nih.gov
This study highlights the major role of HCPs in the implementation of the ICOPE program. Self-assessment enables the enrollment of more robust seniors, allowing for an early detection and treatment.
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If we look at thousands of proteins (i.e., signals) in the human blood, the protein most associated with chronic physical and mental illnesses is the **same protein** as the top marker for mitochondrial diseases: GDF15 When mitochondria cannot flux energy properly, the cell
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Exited to share our latest review with @SoutoPhilipe on #Sarcopenia & the biological determinants of aging; Winner is Mitochondrial dysfunction! 🧬 We dive into the role of geroscience in age-related muscle decline.@brunovellas @INSPIREPlatfor1 @I2mcT
https://t.co/CdEgU0ItX8
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The powerhouse analogy has expired Like social organisms mitochondria differentiate and specialize to accomplish complex functions 🧵
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Excited to share our collaborative study with @BarteltLab @MoriLabe @HenverBrunetta, now online @embojournal on a novel function of mitochondrial IF1 in thermogenesis. Grateful for the support from IHU HealthAge @INSPIREPlatfor1 @I2mcT @MitoAging
https://t.co/BhgPbcjOrP
embopress.org
imageimageHow the hydrolytic activity of mitochondrial ATP synthase is modulated during brown adipose tissue (BAT) thermogenesis remains unexplored. This study demonstrates that reduction of inhibi...
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The time to think and inquire are precious. Inquiring means to contemplate a problem without needing an immediate answer, to sit in the unknown long enough that different kinds of answers emerge. Important part of the process of discovery. https://t.co/4ieOlwNGWZ
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Congratulations to Y ROLLAND from Toulouse for his last publication about #ICOPE : "Implementing clinical operationalization of sarcopenia: the contribution of WHO ICOPE program." https://t.co/8oOh99CwXs
@brunovellas
@isaperarnau @RestoreInstitut @InfinityTLS @I2mcT
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Thrilled to be associated with this study from @BarteltLab, @MoriLab, and the brilliant @HenverBrunetta, uncovering a novel role of mitochondrial IF1 in the reverse mode of ATP synthase, enhancing bioenergetics in brown adipocytes @I2mcT @INSPIREPlatfor1
biorxiv.org
While mechanisms controlling mitochondrial uncoupling protein-1 (UCP1) expression and function in thermogenic adipocytes play a pivotal role in non-shivering thermogenesis (NST), it remains unclear...
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Mitochondrial respiration atlas reveals differential changes in mitochondrial function across sex and age
biorxiv.org
Organ function declines with age, and large-scale transcriptomic analyses have highlighted differential aging trajectories across tissues. The mechanisms underlying shared and organ-selective...
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Will the Gates Foundation’s preprint-centric policy help open access?
nature.com
Nature - Revised policy says grant recipients must share manuscripts as preprints — and removes support for article-processing charges.
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The French Purine Club is happy to introduce you to the speakers for our second Webinar: Pr. Maria Domercq Pr. Kenneth Jacobson Pr Alexander Pfeifer To attend the webinar, save the date and please follow the link: https://t.co/r84w2fpdrx
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What an excellent meeting in Albuquerque covering basic and clinical research in Geroscience @GeroscienceCT
Start of the ICFSR/Geroscience Task Force in Albuquerque and online! #mitochondria #geroscience #aging
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