INSPIRE Platform - IHU HealthAge
@INSPIREPlatfor1
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A unique study launched by the Toulouse University Hospital and its Partners to identify biomarkers on aging & better understand the biological process of aging
Toulouse, France
Joined October 2019
๐จ Late-Breaking Call for Abstracts โ Now Open! Share your latest findings at #ICFSR26 and help shape the future of research on #frailty, #sarcopenia, #intrinsiccapacity & healthy longevity. ๐
Deadline: Jan 20, 2026 ๐ Submit now: https://t.co/vSaX42xgVL ๐ Learn more:
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Congratulations ! #IHUHealthAge contributes to "EMito-Metrix enables automated evaluation of mitochondrial morphology across species." https://t.co/qhgdC0tPAd
@brunovellas @I2mcT @LiMitAging @DrayCedric
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Bravo ! #IHUHealthAge contributes to "ApoJ and apoL1 as novel determinants of MASH: a cross-sectional study." https://t.co/hNq1Fn9wLE
@brunovellas @LiMitAging @I2mcT
lipidworld.biomedcentral.com
Background Plasma apolipoproteins are linked to cardiometabolic dysfunctions, but their potential as biomarkers for metabolic dysfunction-associated steatohepatitis (MASH) remains underexplored....
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Also in fish "Enhanced C/EBPฮฑ Function Extends Healthspan and Lifespan in the African Turquoise Killifish" https://t.co/TSDUHgQsqb
@brunovellas @DrayCedric @RollandYves2 @SoutoPhilipe @I2mcT
onlinelibrary.wiley.com
Mutation of the upstream open reading frame (uORF) in the CEBPA gene in short-lived killifish, resulting in unrestrained activity of the C/EBPฮฑ transcription factor, is associated with increased...
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Translational : "Building an Interdisciplinary Workforce in Geroscience: Aligning Perspectives and Educational Goals" https://t.co/sdQvQXEQyC
@brunovellas @UToulouse71150
academic.oup.com
Abstract. The National Institute on Aging-funded Geroscience Education and Training Network held the โBuilding an Interdisciplinary Workforce in Geroscienc
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Aging rates in "Unlocking longevity through the comparative biology of aging" https://t.co/Km19yyPgZl
@brunovellas @I2mcT @LiMitAging @RollandYves2
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Improving healthspan in "Nutrition and Aging Biology: Summary of a Research Centers Collaborative Network Workshop and Research Needs" https://t.co/Mm8J7RIOOa
@brunovellas @RollandYves2
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Another biomarker of aging "Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures" https://t.co/kmShPeGBaK
@brunovellas @LiMitAging @I2mcT
cell.com
A 50-year multi-tissue proteomic atlas reveals transcriptome-proteome decoupling, proteostasis decline with amyloid accumulation, and asynchronous aging clocks, identifying circulating senoproteins...
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Organ age and mortality in "Plasma proteomics links brain and immune system aging with healthspan and longevity." https://t.co/Czy9zpbsv7
@brunovellas @I2mcT @LiMitAging
nature.com
Nature Medicine - In a large-scale proteomic study of biological aging of 11 organs from 44,498 individuals in the UK Biobank, the biological ages of the brain and immune system emerged as strong...
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@IHUHealthAge contributes to metabolic health in "Brown adipose tissue activity impacts systemic lactate clearance in male mice." https://t.co/skQkFatCDA
@brunovellas @DrayCedric @RollandYves2
physoc.onlinelibrary.wiley.com
Abstract figure legend Using lactate tolerance tests and in vivo 13C isotopic tracing experiments performed in male mice housed at different temperatures, this study demonstrates that the state of...
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โณ 48 HOURS LEFT! Submit your abstract for #ICFSR26 by Oct 8. Be part of the global forum on #intrinsiccapacity, frailty & #sarcopenia research. ๐
Deadline: Oct 8 โก๏ธ Submit now:
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Molecular and cellular changes : "Altered translation elongation contributes to key hallmarks of aging in the killifish brain" https://t.co/Ypc1nDMJ3Y
@brunovellas @GuyonnetSophie2 @I2mcT
science.org
Aging is a major risk factor for neurodegeneration and is characterized by diverse cellular and molecular hallmarks. To understand the origin of these hallmarks, we studied the effects of aging on...
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Five cardinal features : "Hallmarks of stem cell aging" https://t.co/LppFEuTE1i
@brunovellas @LiMitAging @barreto @RollandYves2
cell.com
Aging disrupts core functions of somatic stem cells throughout the body, leading to impaired tissue maintenance and repair. We identify five key features of aged stem cells, highlighting how their...
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An article from KOLs "Advancing Geroscience Research โ A Scoping Review of Regulatory Environments for Gerotherapeutics" https://t.co/FIgl3nIjP3
@brunovellas @RollandYves2
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Bravo to WH LU #IHUHealthAge for "Associations of Skin Biomechanical Properties With Biological Aging Clocks and Longitudinal Changes in Intrinsic Capacity in Adults Aged 20โ93: The INSPIREโT Project" https://t.co/SL6QLZcgWe
@brunovellas
onlinelibrary.wiley.com
This study assessed skin biomechanics using the Cutometer in 441 community-dwelling adults aged 20โ93 from the INSPIRE-T cohort. We demonstrated that skin elasticity and viscoelasticity parameters...
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Deadline : 8th October 2025. Don't forget to submit your work !!!
Call for Abstracts โ #ICFSR2026 March 10โ12, 2026 | Washington, DC New categories this year: โ
Geroscience โ
Intrinsic Capacity (WHO / ICOPE) โ
Frailty โ
Sarcopenia โ
Biotech Showcase Sessions ๐ข Share your latest discoveries in frailty & aging science! ๐ Submit now:
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Cellular senescence in "Identification of miR-106b-5p as a senolytic miRNA" - eBioMedicine https://t.co/7E527RZxiZ
@brunovellas @infinity @I2mcT
thelancet.com
miR-106b-5p functions as a senolytic miRNA via modulation of the p53-PUMA axis and SASP suppression. It holds promise as a therapeutic agent to mitigate age-related cellular dysfunction and inflamm...
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Congratulations to @guyonnetsophie2 of the Toulouse #IHUHealthAge team for "The INSPIRE-T longitudinal observational study centred on intrinsic capacity: baseline data" https://t.co/aIKPbInb00
@brunovellas
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From B. VELLAS, founder & director of the Toulouse #IHUHealthAge project, "Moving geriatric medicine to healthy longevity with Integrated Care of Older People"
academic.oup.com
In most western countries, geriatric medicine was funded several decades ago not because the ageing of our society was anticipated, but because many older
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Hot off the press !!! "Advancing Geroscience research - A scoping review of regulatory environments for Gerotherapeutics." https://t.co/nacJ99cLkW
@brunovellas @InfinityTLS @I2mcT @LiMitAging @RollandYves2
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