INSPIRE Platform - IHU HealthAge
@INSPIREPlatfor1
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A unique study launched by the Toulouse University Hospital and its Partners to identify biomarkers on aging & better understand the biological process of aging
Toulouse, France
Joined October 2019
Hot off the press !!! "Advancing Geroscience research - A scoping review of regulatory environments for Gerotherapeutics." @brunovellas @InfinityTLS @I2mcT @LiMitAging @RollandYves2.
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#IHUHealthAge mentioned as a promoter of ICOPE and Intrinsic Capacity through its #INSPIRE-T cohort. Congratulations to all our researchers ! @brunovellas @InfinityTLS @I2mcT @N_Fazilleau @LiMitAging @DrayCedric.
šļøOur July issue is live!š·This month, we're featuring work on intrinsic capacity, senescence, and more. Read it all here:
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Bravo to C. BRODEAU & al, for this new #IHUHealthAge/#INSPIRE publication on "Identification of Functional Cellular Markers Related to Human Health, Frailty and Chronological Age" @brunovellas @InfinityTLS @I2mcT.
onlinelibrary.wiley.com
Human skin fibroblasts inĀ vitro preserve the memory of age and health.
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"Biomarkers of Aging - NIA Joint Symposium 2024: New Insights Into Aging Biomarkers" @brunovellas @RollandYves2.
onlinelibrary.wiley.com
Summary of key points raised by the Biomarkers of AgingāNIA Symposium 2024.
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A combination of treatment in "The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan." @brunovellas @InfinityTLS @I2mcT @RollandYves2.
nature.com
Nature Aging - Gkioni et al. show that trametinib, which targets the RasāMekāErk pathway, extends lifespan in male and female mice and that co-treatment with the known geroprotector...
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Measurement of taurine concentration in "Is taurine an aging biomarker?"@brunovellas @InfinityTLS @I2mcT @RollandYves2.
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For biomarkers of aging ? "The MitochondriaāTargeted Peptide Therapeutic Elamipretide Improves Cardiac and Skeletal Muscle Function During Aging Without Detectable Changes in Tissue Epigenetic or Transcriptomic Age" @brunovellas @InfinityTLS @I2mcT.
onlinelibrary.wiley.com
The effects of the mitochondria-targeted peptide therapeutic elamipretide on age-related muscle function were compared with its effects on molecular biomarkers of aging. It was found that elamipret...
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Read : the United Nations brief on the Biology of Aging
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New : congratulations to the #IHUHealthAge team in Toulouse for "HealthAge: evaluation of intrinsic capacity changes in humans, mice, and killifish to explore the biology of aging" @brunovellas @I2mcT @GuyonnetSophie2 @DrayCedric @InfinityTLS.
pubmed.ncbi.nlm.nih.gov
HealthAge was devised by a conglomerate of research groups in Toulouse, France, with the combined goal of narrowing the lifespan-healthspan gap through novel translational bench-to-bedside research...
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Following #BuckInstitute's & #IHUHealthAge's last publication here is a point of view from China "Developing a blood-based epigenetic clock for intrinsic capacity." Nat Aging (2025). @brunovellas.
nature.com
Nature Aging - Intrinsic capacity, the composite of an individualās physical and mental capacities, is fundamental to healthy aging. Fuentealba and colleagues use DNA methylation data to...
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Bravo for this major #IHUHealthAge Toulouse & #BuckInstitute California collaboration "A blood-based epigenetic clock for intrinsic capacity predicts mortality and is associated with clinical, immunological and lifestyle factors". Nat Aging. @brunovellas.
nature.com
Nature Aging - Fuentealba and colleagues build and validate a DNA methylation clock of intrinsic capacity (IC) to bridge resource-intensive clinical assessments of IC with molecular readouts of...
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RT @TimePieChina: A New Blood-based Epigenetic Clock for Aging: IC Clock. Dr. David Furman @BuckInstitute and the team @INSPIREPlatfor1 etā¦.
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Congratulations to the Toulouse INSPIRE & IHU HealthAge teams for "Pathogenicity of commensal gut biofilm in prefrail aging" @brunovellas @I2mcT @InfinityTLS.
pubmed.ncbi.nlm.nih.gov
Pathophysiological mechanisms of unhealthy aging, particularly the transition from robustness to frailty, remain poorly understood. Despite extensive microbiome research on taxonomy, the behavior of...
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TEs and the aging process in "Exploring the Relationship of Transposable Elements and Ageing: Causes and Consequences." @brunovellas @InfinityTLS @I2mcT @LiMitAging.
academic.oup.com
Abstract. Ageing is a gradual biological process marked by a decline in physiological function, increasing susceptibility to disease, and mortality. Transp
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Longevity in "Promoting health and survival through lowered body temperature." @brunovellas @InfinityTLS @I2mcT @LiMitAging.
nature.com
Nature Aging - Growing evidence indicates that lowered body temperature prolongs lifespan and contributes to the effects of calorie restriction across species. Conti and de Cabo discuss the...
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Toulouse : an efficient collaboration for the @INSPIREPlatfor1 & #IHUHealthAge program, with "Mitochondrial bioenergetic profiling in T cell subsets associates with functional health in older adults: A cross-sectional analysis from the INSPIRE-T cohort"
academic.oup.com
Abstract. Aging varies across individuals, highlighting the need for better markers of functional decline. This study investigates the hypothesis that T ce
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Age-related disease in "Chronic inflammation and the hallmarks of aging." @brunovellas @InfinityTLS @LiMitAging @I2mcT.
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About body composition : "Genetic determinants of muscle health: A population-based study" @brunovellas @LiMitAging @I2mcT @InfinityTLS.
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Bravo P. VALENZUELA for this paper. A super collaboration with the Toulouse Institute on Aging team highlighting the work done within the #IHUHealthAge program. @brunovellas @LiMitAging @InfinityTLS @I2mcT @DominiqueLangin @N_Fazilleau.
Now online in @GeroScienceAGE! . The first study from my stay at Institute on Aging @WHOCenterFrailt. We analyzed the association of epigenetic clocks with functional ability and intrinsic capacity in very old adults.
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