Léa Chauveau
@LeawChauveau
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PhD @ChetelatLab | Postdoc at DeMON lab
Joined March 2020
My last PhD paper is out: https://t.co/WHRmNFdYxF Thank you to all co-authors and the amazing journey to your side @Neuropresage @SilverSanteEU @Inserm @Universite_Caen @Cyceron14 Now ready for new adventures!
link.springer.com
Background Cortico-hippocampal functional networks, specifically the anterior-temporal (AT) and posterior-medial (PM) systems, are crucial for memory and highly vulnerable to aging and Alzheimer’s...
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does 🧠 connectivity drive spread of pathological proteins in Alzheimer’s disease? if this question intrigues you, please check out our new preprint: https://t.co/SJFBq5aGiZ and/or read on.. 🧵⤵️
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𝗟𝗮𝗿𝗴𝗲-𝘀𝗰𝗮𝗹𝗲 𝗻𝗲𝘁𝘄𝗼𝗿𝗸𝘀 𝗯𝗮𝘀𝗲𝗱 𝗼𝗻 𝗳𝗠𝗥𝗜 What are good masks or parcellations that allow one to determine the network label of subcortical ROIs? For example, this amygadala ROI --> defaultA @LucinaUddin @bttyeo @AFornito ?
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Can AI reveal the risk and co-pathology of multiple neurodegenerative diseases from just a single blood sample? We explored the AI-based diagnostic power on a massive sample (N=17,170) and high-rank plasma proteomics data. https://t.co/kgBbWGVWAP
#MedSky #neuroskyence #neurosky
medrxiv.org
Co-pathology is a common feature of neurodegenerative diseases that complicates diagnosis, treatment and clinical management. However, sensitive, specific and scalable biomarkers for in vivo pathol...
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Take-home message: Specific cardiovascular modifiable risk factors contribute to functional brain aging in the PM network, likely independent of AD
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Full paper also explores: - Modulatory effects of healthy lifestyle habits and AD risk factors - Sensitivity analyses to account for key confounders
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Results breakdown: - LDL cholesterol, waist circumference, smoking duration and alcohol consumption were linked to lower PM connectivity - Together they explain 11.4% of PM variance - LDL = strongest and most robust effects - NO association with AT connectivity
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Here, we assessed whether—and which—modifiable cardiovascular risk factors are associated with altered functional connectivity patterns in cognitively healthy older adults Using longitudinal resting-state fMRI in 131 participants 65+, we focused on AT and PM hub connectivity
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MTL functional networks—the anterior-temporal (AT) and posterior-medial (PM) systems—are key for memory-guided behavior. Our prior work showed these networks are highly vulnerable to aging and AD: https://t.co/R7qBa2IXo8 But how can we help protect them?
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Functional connectivity alterations in aging and Alzheimer's disease align distinct cortical gradients ⬇️ — check out @jorittmo's impressive work and talent for figures!
How does the brain reorganize in the context of age and AD? Are functional changes in age and AD similar? Are these changes dynamic across the age/AD spectrum? We unpack these questions in a sample of N=973 with AD biomarkers Preprint: https://t.co/iaqtO68ghK 1/ ⬇️🧵
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Fascinating new insights into the differential drivers of tau presence vs. tau load👇 check out this impressive work from @xiaoyucaly!
🧠New preprint alert! Tau, the pathological protein in AD, spreads through the brain in a very particular pattern. But what drives this pattern? We found that WHERE tau pathology appears, and HOW MUCH accumulates there, are governed by different mechanisms. Check out our
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Just joined the lab and can already tell—fantastic mentors and a great place to grow in neurodegenerative disease research!
‼️PhD Position now available in my lab‼️ Do you like: * Neurodegenerative disease? * Neuroimaging and/or multi-omics? * AI and data-driven life science? Want to work with @RikOssenkoppele Alexandra Young and Laura Wisse? Apply here: https://t.co/aQ3g5pZWJe Please rt/share 🙏
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Our paper on MTL network connectivity in aging & AD is finally out in @Brain1878! with @RobindeFlores @ChetelatLab @Neuropresage
By analysing functional connectivity within medial temporal lobe networks, Chauveau et al. provide evidence that hyperconnectivity within the anterior-temporal network is key to the pathophysiology and progression of Alzheimer's disease. https://t.co/rQNMbGMiqm
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Absolutely deserved – bravooo 👏
I’m honored to receive the Joel Ménard Award from @StopALZ for my research contributions to Alzheimer’s disease. A huge thank you to my mentors, colleagues, and everyone who has supported me throughout my journey. Grateful for this recognition!
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Encadrantes très compétentes et bienveillantes + super labo + atmosphère de travail très épanouissante ⬇️
🚨Urgent - Thèse financée dans notre laboratoire (#phdoffer) Je cherche un.e étudiant.e motivé.e pour une thèse sur l’effet du sexe/genre dans les liens style de vie et vieillissement cognitif et cérébral https://t.co/quBjS9cpdZ N’hésitez pas à diffuser largement! #these
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‼️ Postdoc ad // Please RT/circulate ‼️ Are you interested in * Big euroimaging and multi-omic data? * Neurodegenerativ disease? The @biofinder_study is looking for a talented postdoc to sink their teeth into some rare and exciting data! Apply here: https://t.co/VNuy96cazu
lu.varbi.com
Description of the workplace We study the biological processes behind Alzheimer's disease (AD) and other neurodegenerative diseases. We work with cohorts of patients and cognitively healthy volunteers
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🔜@Neuropresage at #ADPD2024🧠: Dr G. Chételat will give a talk about #AD lesions, pathology & propagation on March 8 and @HaudrySacha, PhD student will present a poster on March 6-7 about #meditation mechanisms! Details here👇 Feel free to come & talk to them🎉#brain #Science
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Opening of a #PhD position in #neuroimaging- #cognitive neurosciences in Lyon, France. To apply for this position, please send a CV with references, cover letter to antoine.lutz@inserm.fr @Inserm
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🧠 Calling all researchers imaging hippocampal subfields! 📢 We're seeking your valuable feedback on our draft protocol for the hippocampal tail. Your insights are crucial! @anne_maass @GervNiki
Happy #SubfieldWednesday HSGers, Our questionnaire relating to the hippocampal tail segmentation protocol is live! Your feedback will help to revise and improve a draft protocol for defining hippocampal tail boundaries. Responses are requested by Monday January 8, 2024. 🍤
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Our findings allowed us to clearly identify AD-signature network dysfunction. (4/4)
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