Layla Siraj, Ph.D.
@LaylaSiraj
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Future Ob/Gyn, @HarvardMITmdphd w/ Eric Lander and Hilary Finucane @broadinstitute and @harvardGSAS Biophysics, exploring epigenetics & gene regulation
Cambridge, MA
Joined July 2019
RT @EdlowLab: Edlow Labsgiving! So fun!🍗🦃🥧. And joined by our guest speaker and collaborator Kate Dannheim to talk about the placenta. very….
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RT @i_rodcast: Excited to share our sequence design work published in @Nature. I had the privilege of co-leading this effort alongside my f….
nature.com
Nature - A generalizable framework to prospectively engineer cis-regulatory elements from massively parallel reporter assay models can be used to write fit-for-purpose regulatory code.
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RT @TheAmirSiraj: Excited to speak and perform tonight at @SmithsonianNPG for Our Universe, Our Future, the kickoff of the .@Smithsonian $….
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RT @PardisSabeti: Thrilled to introduce Delphy for fast, accurate, scalable Bayesian #phylogenetics. Web: Whitepape….
github.com
Fast, scalable, accurate and accessible Bayesian phylogenetics - broadinstitute/delphy
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We find a total of 37K expression-modulating variants (emVars) with allelic differences in transcription. Building on previous work from @jraylab, we show that emVars from annotated cis-regulatory elements (CREs) capture likely causal variants with high precision. 4/n
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As part of @ENCODE_NIH, we now test a whopping 39K likely causal variants (posterior probability > 0.5) and 89K distinct signals (credible sets) in MPRA across 5 diverse cell types. 3/n
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Understanding how non-coding variants – the bulk of GWAS hits – function at the molecular level remains a huge challenge. We previously fine-mapped variants associated with complex traits in the @uk_biobank and BBJ as well as eQTLs in @GTExPortal. 2/n.
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Could not be more delighted to present our work investigating how over 220,000 complex and molecular trait-associated genetic variants affect transcriptional regulation using massively parallel reporter assays!.See below for a 🧵. 1/n.
biorxiv.org
Identifying the causal variants and mechanisms that drive complex traits and diseases remains a core problem in human genetics. The majority of these variants have individually weak effects and lie...
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RT @Princeton: A new study from #PrincetonU's @TheAmirSiraj shows that there may be rogue planets the size of Mars existing in the outer so….
phys.org
A recent study published in the Astrophysical Journal Letters investigates the potential existence of Mars-sized free-floating planets (FFPs)—also known as rogue planets, starless planets, and...
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RT @NobelPrize: BREAKING NEWS.The Royal Swedish Academy of Sciences has decided to award the 2023 Sveriges Riksbank Prize in Economic Scien….
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RT @NobelPrize: Historically, much of the gender gap in earnings could be explained by differences in education and occupational choices. H….
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RT @NobelPrize: BREAKING NEWS.The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their….
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RT @SagerGosai: I’m excited to share some work I co-lead with @i_rodcast and spanned the labs of @PardisSabeti, @ReillyLikesIt, and @r_tewh….
biorxiv.org
Cis -regulatory elements (CREs) control gene expression, orchestrating tissue identity, developmental timing, and stimulus responses, which collectively define the thousands of unique cell types in...
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RT @Princeton: After years of effort, says #PrincetonU's @TheAmirSiraj, researchers may have found pieces of IM1, "a kitchen sink-sized chu….
scientificamerican.com
Tiny spheres of once-molten metal magnetically dredged from the seafloor could be pieces from IM1, a potential interstellar meteor that struck Earth in 2014
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RT @TheAmirSiraj: Here’s the ~short version~ of the three-year-long saga that resulted in the confirmation of the first interstellar meteor….
scientificamerican.com
A high-speed fireball that struck Earth in 2014 looked to be interstellar in origin, but verifying this extraordinary claim required extraordinary cooperation from secretive defense programs
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RT @TheAmirSiraj: We’re back from the Pacific ocean! Check out the details in my commentary for @sciam.
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RT @HarvardMITmdphd: So proud of @HarvardMITmdphd student @LaylaSiraj for her successful thesis defense entitled, “Characterizing Regulator….
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