Jonathan Friedman
@LabFriedman
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Associate Professor in Cell Biology at UTSW, studying how organelles are shaped and organized
Dallas, TX
Joined August 2010
Some good news (and fresh science) to break things up! Our work identifying a subpopulation of compositionally unique mitochondria that localize to filopodia and promote cell migration is now online @CurrentBiology! Led by fantastic @madeleinemarlar! https://t.co/bQsUgC4L2y
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Thrilled to announce my official promotion to associate professor with tenure at UTSW! So grateful to all the trainees in the lab for their hard work and proud of their accomplishments over the last several years. This an individual recognition but truly a team effort!
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Does anyone have a favorite mNeonGreen antibody that works well for western and IPs?
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Very excited to share our latest work, “Mitochondrial presequences harbor variable strengths to maintain organellar function,” led by the fantastically talented @WashUBBSB graduate student Youmian Yan. A 🧵 https://t.co/UbrKcjoESv
biorxiv.org
Hundreds of mitochondrial-destined proteins rely on N-terminal presequences for organellar targeting and import. While generally described as positively charged amphipathic helices, presequences lack...
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Important to celebrate trainee victories: excited to have @HollyMerta's paper out in @CellReports. We use TurboID sub-organelle proteomics to map the ER network. We discover calmin/CLMN, an ER-to-actin tether regulating focal adhesions & cell motility. https://t.co/jTN7j9kmSi
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If you are on UTSW campus May 16, please join us for the Lipid Metabolism & Neurodegenerative Disease mini-symposium! Many thanks to keynote speaker Dr. Hugo Bellen.
Don’t miss out on the Lipid Metabolism and Neurodegenerative Diseases 2025 Mini Symposium! Check out the agenda below for the full details ⬇️
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Reminder to join us tomorrow at 12pm ET
Be sure to mark your calendars for March 26th at 12pm ET for the @AsbmbLrd seminar series. We have two great mitochondria-focused lipid talks planned from @JasonCasler1 from Laura Lackner's lab and Kailash Venkatraman from @ibudin's lab. Register here! https://t.co/3fYn3MKUNT
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Be sure to mark your calendars for March 26th at 12pm ET for the @AsbmbLrd seminar series. We have two great mitochondria-focused lipid talks planned from @JasonCasler1 from Laura Lackner's lab and Kailash Venkatraman from @ibudin's lab. Register here! https://t.co/3fYn3MKUNT
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For #teamtomo, context is everything. We highlight the power of #surfacemorphometrics in guiding STA and quantitatively assessing the impact of these structures on the local environment. @benjaminbarad
Ya-Ting Chang, @nani_grotjahn et al. @scrippsresearch present a membrane-guided approach for identifying a subset of cytoplasmic #ribosomes oriented for protein import on the surface of #mitochondria in budding yeast using #cryoET
https://t.co/D5DKSak1cb
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Happy to announce I am serving as Director of the Lipid Metabolism & Neurodegenerative Diseases (LMND) Program at UTSW. Our goal is to stimulate collaborations bridging lipid metabolism & neurological disease. So proud of our lab & their cell biology adventures! #onward_science
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Edington et al. @labfriedman @UTSWMedCenter identify a mitochondrial inner membrane protein that marks and facilitates a subset of sites of mitochondrial fission in human cells. https://t.co/lkIKOm1SYb
#Organelles #Mitochondria
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Looking for some holiday reading material? Our latest paper identifying a new player in mitochondrial fission is now out @JCellBiol! A wonderful early present to see this now online! https://t.co/qwRvow8rQK
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As you're planning out your ASCB schedule be sure to attend the organelle-focused special interest group hosted by @nieminm and myself Mon. 12/16 at 5pm
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Honored and excited to present some of our latest work as part of this session!
Join JCB Session 🗓️ Sat. December 14 11:15am at #CellBio2024! @s__ellis, @LabFriedman, @Meng2Fu, @BinyamMogessie, & Andrew Muroyama will discuss how new techniques in cell biology are revealing insights into how cells function across different scales. 👉 https://t.co/q8taMahSq3
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Be sure to check out @MitOtalks Thursday (10am US central time) for a double feature, including our amazing student Alia @TheMitotracker who will be presenting her work identifying a new player in mitochondrial fission! You can find a zoom link at https://t.co/jd47Fs1IZu
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Interested in BNIP3/NIX-mediated mitophagy? Check out our new review, written with @LabFriedman, about recent advances in the field and our thoughts on the regulation of these mitophagy receptors in space and time. https://t.co/TXABmMGKvv
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Seen a flurry of papers about BNIP and NIX and mitophagy the last few years and want to learn more? Check out this new review that @nieminm and I wrote to put them in context.
portlandpress.com
Mitochondria maintain organellar homeostasis through multiple quality control pathways, including the clearance of defective or unwanted mitochondria by selective autophagy. This removal of mitocho...
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Super excited to share our latest work on the native in-cell organization of the mitochondrial respiratory chain 🥳 Using cryo-electron tomography🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria! https://t.co/cxHl1j20CJ
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🚨 New paper alert from @martenssascha!🚨 We explore how transmembrane cargo receptors initiate selective autophagy. Through biochemical reconstitutions, we discover a new autophagosome biogenesis pathway with implications for therapeutic interventions. https://t.co/tud1Iq4RPg
biorxiv.org
Selective autophagy is a lysosomal degradation pathway that is critical for maintaining cellular homeostasis by disposing of harmful cellular material. While the mechanisms by which soluble cargo...
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