Lothar Schermelleh
@LSchermelleh
Followers
538
Following
206
Media
7
Statuses
102
Professor of Bioimaging Nanoscopist with passion for chromatin, epigenetics and nuclear organisation
University of Oxford
Joined October 2017
🎉Huge congrats to Dr. Nick Gatford for earning a prestigious @NikonSmallWorld Image of Distinction award! 🏆 Incredible recognition of his work with the @Zeiss_micro LSM980 confocal at Micron🔬 @KavliOxford @TofarisLab @OxfordMedSci @NDCNOxford 🔗 https://t.co/SrycO3farR
0
11
29
Thank you to all our user community for submitting their beautiful images & PhD student @DannyBHGold for the expert videography
1
2
2
Check out our latest Viewpoint article in @NatRevMCB! Experts share insights on how to approach "resolution" in #superresolution #microscopy, answering six frequently asked questions. Spoiler alert: it's more complex than just a simple number!
1
11
33
A nice surprise: @SjoerdStallinga cited my tweet :) Open discussion is the most productive form of scholarly publication. Smart people can tell good ideas even if they're not in fancy journals, and kind people give high-fives even when they don't have to. Thanks, Sjoerd!
@SuperResoluSian @LennartHilbert @barrosolab Can you "coinflip split" the image? Meaning, scale image counts to photoelectrons, then flip a coin for each photoelectron to decide if it belongs in imaginary subexposure 1 or imaginary subexposure 2?
2
12
103
Come join us in Oxford as an Associate Professor in Molecular and Cellular Biochemistry. We are considering a wide range of research areas, but I would note that we have a vibrant chromatin and gene regulation community. Happy to answer questions if you are interested. Please RT!
4
136
184
The power of SIM for in situ #singlemolecule imaging! Quantitative 3D #superresolution #fluorescence #microscopy settles a longstanding dispute if #cohesin acts as a monomer in sister chromatid cohesion. Proud to have contributed to this awesome study by @OchsFena et al.
Our new paper is out today in @ScienceMagazine showing that sister chromatid cohesion is mediated by individual cohesin complexes. Read about it here: https://t.co/GDjy65YSn1 (1/4)
2
2
24
BEYOND THE DIFFRACTION LIMIT After successful conferences in 2016, 2018 and 2021, we again invite you to attend the 4th International Conference On Nanoscopy 2024 (ICON-Europe 2024), which will uniquely focus exclusively ( https://t.co/7qxocLgJsW).
1
8
24
Clear words. This is how many Germans and Austrians feel.
I have never agreed with every single word a politician has said in a speech. Until now.
90
283
1K
Fantastic work by the Mazza Lab, highlighting the importance of higher-order chromatin organisation to guide the binding of transcription factors! SPT of TFs is so much more impressive when observed in the context of the chromatin landscape!🤩 Well done!!!
...And the manuscript is now out in @NatureComms: https://t.co/BMgUqQtTcP. Here a long-due but (hopefully) short thread:
0
0
10
Join us for the grand opening of the Leica Center of Excellence @MicronOxford! Discover the exciting new opportunities that await the research community at Oxford and beyond. Register here:
micronoxford.com
MICRON BIOIMAGING FACILITY
0
5
21
Lots of fun this week with our first Single Molecule Imaging Workshop in collab with @oniHQ! Thanks to everyone that attended, our great ECR speakers and our visiting speakers @beccysaleeb @D_J_Nieves @SusanSuperRes @kazu_maeshima
1
4
22
Our lab is growing! We are looking for a motivated Postdoc passionate about the role of 3D chromatin organisation in health & disease. Contact me if interested. Our call is part of the MSCA COFUND program LEAD. All details below, deadline is end of September. @UCPH_BRIC
0
24
38
Join us for an exciting day of single-molecule imaging (#SMLM and tracking) @MicronOxford, featuring lectures from world-leading experts, such as @kazu_maeshima, Susan Cox et al., networking over lunch, and afternoon hands-on sessions.
Registration is now open for the @MicronOxford Single Molecule Imaging Workshop in collaboration with @oniHQ. Join us on Sept 12th to learn theoretical and practical knowledge in single molecule imaging! More info here: https://t.co/2I31MQow1z
0
19
34
Great new review by the @kazu_maeshima lab, challenging prevailing models of chromatin organization. Thanks for kindly featuring our work!
Is euchromatin really open in the cell?
1
3
17
Great to see this wonderful work by @AleksSzczurek and @RobKlose finally out on @biorxivpreprint, highlighting the power of quantitative imaging to understand the molecular function of #polycomb. Seeing (& measuring) is believing! https://t.co/7AaV74S2YX
biorxiv.org
The Polycomb system plays fundamental roles in regulating gene expression during mammalian development. However, how it controls transcription to enable gene repression has remained enigmatic. Here...
2
1
21
Great new podcast about PhD careers outside the traditional University setting. Pleasure to hear @EzeMiron thoughts and unsurprisingly a great advertisement for super-res imaging 🔬 🧬 @LSchermelleh @MicronOxford
🎉 Today's the day! 📷We are launching Dr. What Now #podcast with not one but TWO episodes. We can't wait for you to hear them and get your feedback!
1
2
4
We present doubled resolution in light-sheet microscopy via multi-directional structured illumination. This enables SIM imaging at 1Hz volume rate of subcellular dynamics. https://t.co/j63s5yiIRz
13
78
342
With informal lectures, practical workshops and lots of time for #SIM discussions! Come join the fun and apply by July 18th! @LSchermelleh @mueller_physics
@IanDobbie5
@CarinaMonico
@DeeMKav
0
3
3
Applications are now open for our advanced #SIM practical course! If you are an #imagingscientist working in a #corefacility or research group supporting or soon to be supporting SIM projects, then this is the course for you! More info here https://t.co/tF8i29TMJL 🔬
1
16
18
Happy to share our new protocol on sister chromatid labelling for microscopy, dm me if you can’t access and I’ll be happy to share the pdf. @EzeMiron @LSchermelleh @MicronOxford
Replication Labeling Methods for Super-Resolution Imaging of Chromosome Territories and Chromatin Domains by Ezequiel Miron
1
8
27