Laboratory of Genomic Stability
@LGS_IMB
Followers
192
Following
75
Media
4
Statuses
33
Institute of Molecular Biology, Bulgarian Academy of Sciences #DNArepair #Replication #Genomeintegrity #Cancer #Anticancerdrugs #Microscopy
Sofia 1113, Bulgaria
Joined March 2018
We use #AI based #denoising, #segmentation and #tracking to follow dynamics of intra- and inter- chromosomal contacts during mitosis with 8-second resolution
1
0
4
Have you ever wanted to track individual #chromosomes during #mitosis? To do live cell #karyotyping and map the inter- and intra-chromosomal contacts dynamics? Our recent work made that possible. Check out our @NatureCellBio paper: https://t.co/w6iaGC8a6n
1
12
53
https://t.co/pdJlbc6sjs We are glad to see further evidence confirming our finding that loop extrusion is dispensible for the spread of gH2AX (doi: 10.1016/j.isci.2024.110826). #loopextrusion #cohesin #dnarepair #DDR #DSB
nature.com
Nature Communications - Cohesin plays a crucial role in both chromosome organization and DNA repair. Here the authors find that cohesin mediated genome architecture prevents interactions between...
0
3
8
Are you looking forward to 2025 as much as we are? 👀 We just updated our 2025 EMBL Annual Poster to include even more courses and conferences for you to join, so go and have a look! ➡️ https://t.co/QMAxOlmGbR
#EMBLEvents #molecularbiology #lifesciencetraining
1
199
565
”David Baker, Demis Hassabis and John Jumper, your ground-breaking work in computational protein design and protein structure prediction has revolutionised these fields. It has opened up completely new possibilities to design proteins that have never been seen before, and we now
23
276
1K
Congratulations to Bruce Stillman of @CSHL on winning the ASBMB's Stadtman Award. Join us in Hemisfair Ballroom C2-3 for his award lecture, happening now! #DiscoverBMB
3
7
54
How many PCNA/RPA molecules are loaded and removed per min during fork stalling and restart? How do DDR inhibitors influence these dynamics? We estimate these rates in our pre-print, out on bioRxiv: https://t.co/51hfXZSL39
#microscopy #DNArepair #genomestability #DNA #replication
0
2
3
Contributing to efforts toward elucidating the response to replication stress, we provide a precise timescale of fork stalling and restart in live cells, at 30-s resolution (airyscan teaser below). https://t.co/cvLW0YaI5O
#replicationstress #DNArepair #ATR #replication #DNA #RPA
0
13
12
If you are curious whether loop extrusion is required for γH2AX spread and MDC1 recruitment, you can have a look at the most recently published work from our lab out now in iScience #dnarepair #ATM #MDC1 #γH2AX #DDR #loopextrusion #cohesin
https://t.co/os9tFT7Dvt
cell.com
Chromosome organization; Molecular biology; Nucleic acids
0
5
6
If you are curious whether loop extrusion is required for γH2AX spread and MDC1 recruitment, you can have a look at the most recently published work from our lab out now in iScience #dnarepair #ATM #MDC1 #γH2AX #DDR #loopextrusion #cohesin
https://t.co/os9tFT7Dvt
cell.com
Chromosome organization; Molecular biology; Nucleic acids
0
5
6
Happy to share that our collaborative work on SARS-CoV-2 VLP dynamics is now available as a pre-print. #SARSCoV2 #COVID19 #virology #tracking #imaging Kinetic landscape of single virus-like particles highlights the efficacy of SARS-Cov-2 internalization.
biorxiv.org
The efficiency of virus internalization into target cells is a major determinant of infectivity. SARS-CoV-2 internalization occurs via S-protein-mediated cell binding followed either by direct fusion...
0
1
0
We are happy to share our latest paper “A unified mechanism for PARP inhibitor-induced PARP1 chromatin retention at DNA damage sites in living cells”, out today in @CellReports. #PARP1 #PARPinhibitor #GenomicStability Hopefully not a boring thread ↓ https://t.co/MCU6BsbJRQ
cell.com
Employing newly introduced measures of PARP1 dynamics and activity in vivo, Kanev et al. reveal that both catalytic inhibition and allosteric trapping by PARP inhibitors define the overall retention...
2
10
26
🧬Team led by @Alberti_Lab cracks a fundamental #DNADamage question. Broken DNA is held together by an underwater protein superglue💧! Now published in @CellCellPress, with new insights for #cancer therapies. Read more ➡️ https://t.co/tiD5iboR9u
#CMCBnews
1
9
20
We are delighted to share that this tour de force is now out, shedding further light on the mechanisms that keep broken ends close. #parp1 #genomestability #dnadamageresponse #parpinhibitor
Now online! PARP1-DNA co-condensation drives DNA repair site assembly to prevent disjunction of broken DNA ends
0
0
2
How does #PlasmaMembrane repair work? This is what @PNepachalovich of @FedorovaLab aims to understand using super fast #spinningdisc confocal microscopy 🔬in collaboration with experts at @LGS_IMB, our Sofia Node🇧🇬. Learn about this exciting project!⤵️ https://t.co/icTS241zhD
0
1
14
Interested in protein dynamics and #DNArepair? Why not work with the experts at Sofia BioImaging Node? The Node has 2 new instruments for Fluorescence-lifetime imaging microscopy (#FLIM) - and #funding for Bulgarian researchers. Learn more ⤵️ https://t.co/DEKmsXjodr
0
2
2
Our collaboration paper on the resolution of R-loops by INO80 has been published yesterday -
0
2
5
Very fast CRISPR on demand https://t.co/v2PdJK3Ud0
0
1
2