Great message from Tony Hollingsworth to all of us: “We need to review grant applications as if we submitted them.” We need to be able to publish negative results to avoid redundancy and effectively make progress in #PancreaticCancer research. #AACR22

Amazing talk by @ItaiYanai from @nyuniversity about mechanisms of adaptive genome regulation in cancer. I love to leave a talk excited to apply my new knowledge to my scientific questions. I am glad I made it!

https://t.co/gzqkfhEUXl

Once “undruggable”, now very druggable! Our new Trends in Cancer commentary explores how next-gen RAS inhibitors are rewriting the rules of precision oncology - from allele-specific RNAi to dual-state KRAS degraders. #RAS #PrecisionOncology https://t.co/gzqkfhFsMT

It is always fascinating to hear what is going on in the #PancreaticCancer universe, presented by @Aiims1742 himself! I am enjoying the insights at the Think Tank meeting in Munich.

Check out this opportunity for planning your next career step!

Check out this ground breaking work on pancreatic 3D organoid structures by @arispapargyriou in the @MaxReichertMD lab!

On #WorldPancreaticCancerDay I am reminded why I am doing the job I love, even though the days are long and full of struggles. We are working every day on understanding #PancreaticCancer a little better to identify new targets for better, personalized therapeutical approaches.

Why do we need Night Science and why is creativity not taught in science education? @ItaiYanai and @StearnsLab are asking us to take a step back from hypothesis testing and develop our creative, improvisational skills - crucial for generating research ideas as a #FuturePI.

I am honored to announce that NCI puts a lot of faith in me, my science, and my vision for the future. I am excited to work together with the leading scientists of tomorrow to create an inclusive work environment that fosters the interests of every lab member. Stay tuned!

I am delighted I had the chance to meet @CterminiPhD in NYC! Not only did she provide guidance on the transition to independence during trainee lunch but also presented her exciting work about Syndecan-2. Thank you for the great opportunity!

How will @andrewaguirremd strike back?

Let’s start a debate! Have we learned anything from working with KRAS inhibitors that we didn’t learn from mice? @Pasca_Lab takes the lead by reintroducing the KRAS* model system for #PancreaticCancer. #AACRPan24

Kamiya Mehla concludes the session on metabolism in #PancreaticCancer with her perspective on how the innate immune response is shaped by metabolic competition. #AACRPan24

#PancreaticCancer is highly reliant on autophagy. Why are autophagy inhibitors not delivering promising results in vivo? @LyssiotisLab demonstrates an amazing synthetic lethality strategy using PIKfyve inhibition to eradicate the tumor, check out @DJCalebC’s preprint! #AACRPan24

The #PancreaticCancer microenvironment is sparse in nutrients. @AlecKimmelman talks about Serine deprivation and how cancer cells overcome nutrient restriction by communicating with stromal cells. #AACRPan24

Harsh Singh demonstrates a huge (!) study using NGS profiling on over 8,700 #PancreaticCancer patients to find predictors of chemotherapeutic response associated with basal or classical subtype. #AACRPan24

Nicholas T. Woods seeks to determine molecular subtypes by focusing on the proteome as opposed to the transcriptome. Optimal #PancreaticCancer patient stratification would lead to optimized treatment options and better outcomes. Way to go! #AACRPan24

An amazing group of researchers! I am looking forward to future collaborations and scientific exchanges

How does metabolic stress affect stromal and epithelial plasticity? @Cosimo_Commisso demonstrates Glutamine depletion in #PancreaticCancer and its wide-ranging effects in the tumor microenvironment. #AACRPan24

Good morning, Boston! Stephanie Dougan introduces her profound work on TGFbeta blockade in #PancreaticCancer in the plasticity session of #AACRPan24.