Kathryn Knoop PhD
@Kathrynated
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Mucosal Immunologist interested in early life events at Mayo Clinic. All posts represent my own opinions and views. She/her
Minnesota, USA
Joined October 2015
Maternal protection from #breastmilk in late onset sepsis. So pleased this is out in press! #LateOnsetSepsis
pnas.org
Late-onset sepsis (LOS) is a highly consequential complication of preterm birth and is defined by a positive blood culture obtained after 72 h of a...
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I’ll be trying out bluesky, same handle. Let’s connect if you are over there.
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Confused about the flu and COVID-19 vaccines? Let Mayo Clinic expert Dr. Robert Jacobson clear up common myths in this Mayo Clinic Minute. https://t.co/DeItUcnchB
#FluVaccine #COVID19Vaccine
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Bulky pastas—like farfalle and fusilli—require more packaging than thinner varieties, making them trickier to transport and leading to more waste. 🍝 On #NationalPastaDay, learn more about a different twist on pasta dough that could help reshape food manufacturing, according to
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Exciting opportunity to join @Umasschan @Umass__Medicine Division of Cardiovascular Research - please RT
Join our collaborative team of investigators! The Division of Cardiovascular Medicine in the Department of Medicine at UMass Chan Medical School is now accepting applications for a tenure-track faculty position. Learn more and apply: https://t.co/HAnuiHq3SY
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Excited to share that we have moved to @DOM_UCLA! We study intestinal epithelial-immune cell interactions and how these interactions are influenced by changing microbiota 🦠. We look forward to recruiting students and postdocs soon. Watch this space for updates!
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#LongCOVID science, policy & research A new Review outlines the current state of evidence, impacts on patients, health systems, economies & global health metrics, and proposes a research & policy roadmap @zalaly @EricTopol @VirusesImmunity @LisaAMcCorkell
https://t.co/kvgaU3tfhx
nature.com
Nature Medicine - This Review outlines the current state of scientific evidence on long COVID, discusses its impacts on patients, health systems, economies and global health metrics, and proposes a...
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Research Fellowship position available in our lab. At the intersection of cancer cell biology and immunology to dissect mechanisms of immune evasion and therapeutic resistance and develop novel therapies @MayoUrology
https://t.co/ADOdepBDln
fa-euwp-saasfaprod1.fa.ocs.oraclecloud.com
The laboratory of Dr. Lucien-Matteoni https://www.mayo.edu/research/faculty/lucien-matteoni-fabrice-ph-d/bio-20516964 is seeking a postdoctoral fellow (must have Ph.D.) to join the research team. The...
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Dear colleagues, A postdoctoral position is available in my laboratory at UMass Chan Medical School: https://146.189.216.212/bogunoviclab/. We study the relationship between intestinal macrophages and their microenvironment in health and disease. Please share or apply!
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BREAKING: Kamala Harris names Minnesota Governor Tim Walz as running mate - CNN
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Me watching 15 second scenes of Rhaena running around the Vale wondering if she’ll ever claim the dragon. #HouseOfThedragon2ep8
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This was a big group effort from the lab, so thanks to all authors for their hard work! @EmilyLevyMD
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Side note for lovers of #GAPs, we tried to get GBS to translocate. It took both disruption of EGFR AND antibiotics before we could see GBS translocate from the intestine. The reduced ability of GBS to bind mucus may limit its ability to access GAPs in comparison to other microbes
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In surviving pups, we found long term colonization of the intestine by GBS. Immunization of dams before infection increased GBS specific IgA, reduced EOS in pups, and reduced colonization of GBS in the intestine. Maternal IgA for the win!
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To test if maternal IgA could protect against GBS colonization in vivo, we turned to a mouse model of vaginal colonization and transmission of GBS during birth. This results in early-onset like sepsis consistent with the lung as a route of infection in the pups.
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We found GBS frequently in the intestinal microbiota of premature infants in the first few months following birth. Interestingly, we found the relative abundance of GBS negatively correlated with the concentration of IgA in paired milk samples.
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Long term intestinal GBS colonization represents a threat of #sepsis to neonates and here we show how multiple modes of protection combine to restrict GBS in the intestines.
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