Kalli Kappel
@KalliKappel
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HHMI Hanna Gray Fellow & @SchmidtFellows @broadinstitute | Soon: Asst Prof @UCLA | PhD: @Stanford Biophysics @RDasLab | RNA+proteins+IDPs, HT expts+computation
Cambridge, MA
Joined July 2020
In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput method to measure nuclear condensate formation & applied it to ~14000 IDPs to find out https://t.co/qfa8jtvFOp
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Beautiful work led by the brilliant @GraceKC! Check it out!
Can we use RNA to insert kilobases of DNA into the human genome, opening up a new way to engineer cells or treat disease? Excited to share our latest work turning a retrotransposon (a “jumping gene” with an RNA intermediate) from songbirds into a genome editing tool. 🧵 (1/7)
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I will continue building on this approach in my own lab, opening in July at UCLA — if you’re interested in this kind of work, please reach out!
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I’m super grateful to all my co-authors for helping to make this project a reality, especially my postdoc advisors Aviv Regev and Feng Zhang.
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Introducing CondenSeq, an imaging-based high-throughput approach for characterizing protein condensates within the nuclear environment. @KalliKappel
https://t.co/M6mIQAqs38
nature.com
Nature Methods - CondenSeq is an imaging-based, high-throughput platform for characterizing condensate formation within the nuclear environment, uncovering the protein sequence features that...
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We're also recruiting postdocs, learn more and apply here:
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The Kappel Lab is opening soon at UCLA and we’re hiring Staff Scientists to help lead our wet-lab projects & to assist with lab management! We have open positions for candidates with a PhD & for recent college grads. Learn more and apply: https://t.co/CoupN3mPHm Please RT!
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Finally, we will be recruiting postdocs, grad students, undergrads, and RAs! If you’re interested in doing exciting computational + experimental science in beautiful, sunny Los Angeles, please reach out!
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I also want to thank the @HHMINEWS Hanna Gray Fellows community for support throughout my postdoc, and especially during the job search process. I am so grateful to be part of this inspiring community!
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I am also incredibly thankful for support from @SchmidtFellows — I made a challenging scientific pivot from grad school to my postdoc and their support was absolutely critical.
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So excited to announce that the Kappel Lab will open at @UCLA @uclachem in July 2025! We’ll combine high-throughput experiments and computation to build predictive sequence-structure-function models of RNA, proteins, and their interactions. More here:
sites.google.com
Kappel Lab @ UCLA Combining high-throughput experiments and computation to decipher sequence-organization-function relationships of RNA, proteins, and their interactions
We’re excited to announce that five talented researchers and educators will be joining our department in the coming months! Learn more: https://t.co/T7G3Ep2agf
@TomPFay @KalliKappel @LindertLab @petroviclab @uclaphyssci
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This is so cool! Congratulations Dan!!
Excited to share DIRECTED (Delivery to Intended REcipient Cells Through Envelope Design): a programmable platform for cell-type-specific delivery. https://t.co/CRGaG3szJ5 Thank you to @FrangiehChris, @mircoscopy, @GuilhemFaure, Rhiannon Macrae, @zhangf 1/7
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Excited to share this work!
nature.com
Nature - The cryogenic-electron microscopy structure of the D. thermocuniculi IsrB protein in complex with its cognate ωRNA and a target DNA shows that the RNA-dominant IsrB effector complex...
We’re excited to report today in @nature the cryo-EM structure of the OMEGA family member IsrB in complex with ωRNA and target DNA. https://t.co/jwlPWHUr0J
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Out now in @Nature: 🧬 Structure of the OMEGA nickase IsrB in complex with ωRNA and target DNA. By Seiichi Hirano, Kalli Kappel, Feng Zhang & colleagues. @KalliKappel @zhangf
https://t.co/PAswS3KrPa
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Our high resolution cryo-EM structures of the Tetrahymena ribozyme are out @nature! Congrats @SuZhaoming @kaiming_zhang @RDasLab @chiulab!
nature.com
Nature - Cryo-electron microscopy has been used to determine the structure of the Tetrahymena ribozyme (a catalytic RNA) at sufficiently high resolution to model side chains and metal ions.
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Honored and grateful to be selected as one of the new HHMI Hanna Gray Fellows! Huge thanks to my mentors Aviv Regev, @zhangf, and @RDasLab and all my wonderful colleagues at the @broadinstitute!
Today, HHMI is proud to announce the new #HannaGrayFellows, 21 early career researchers who are taking on some of the biggest challenges in the life sciences.
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Excited that our paper describing accelerated 3D RNA structure determination is out @naturemethods! This was an amazing collaborative effort with @chiulab, especially @kaiming_zhang and Zhaoming Su, and many wonderful @RDasLab members:
Ribosolve accelerates RNA 3D structure determination with cryo-EM, multidimensional chemical mapping, and Rosetta modeling. @KalliKappel's paper on Ribosolve is now at @naturemethods, with 11 sub-nanometer resolution structures for protein-free RNA: https://t.co/ag6DmPSQ4G
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